An interventional study of Microencapsulated Sublingual Glycine (MSG) and Placebo in Healthy, Stress, Psychological and Cognitive Impairment, sponsored by Daacro. Completed at 1 site in Germany. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-07-26.
Sponsored by Daacro · Not applicable, Interventional, and Treatment
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Among 27 studies in Stress, Psychological with a site in Germany — 6 open to participants now, 7 under way, none of them phase 3. Stress, Psychological · Germany.
Among the 27 studies in Stress, Psychological with a site in Germany, this one is the 10th largest by enrollment of the 19 interventional ones that give a count, is one of 2 that started in 2017, is one of 19 with no phase, and was the 5th registered.
848 studies on the registry are indexed under Stress, Psychological; 139 are open to participants now.
Browse Stress, Psychological studies →6 of the 27 studies in Stress, Psychological with a site in Germany are open now. Recruiting first, the newest first:
University of Cologne · Sites in Germany
Ages 1 days–7 days · Healthy volunteers
Charite University, Berlin, Germany · Sites in Germany
Ages 18+ · Healthy volunteers
University Hospital Augsburg · Sites in Germany
Ages 18+
Charite University, Berlin, Germany · Sites in Germany
Ages 18–70
University Hospital, Aachen · Sites in Germany
Ages 18+ · Healthy volunteers
A study can be open while its sites in Germany have not opened yet or have stopped. Only those recruiting at a site in Germany →
Of the 75 Stress, Psychological studies recruiting now, 34 (45%) set no upper age limit and 37 (49%) stop at 75 or younger; 14 take children under 18; 49 take healthy volunteers.
This study: 18 Years to 40 Years · male · healthy volunteers too.
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27 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 2 started in 2017.
This study's enrollment of 90 is close to the median of 84 across 692 interventional studies indexed under Stress, Psychological.
Median enrollment 90 across the 19 interventional studies, 207 across the 8 observational. Of the 17 that completed or were terminated, 1 (6%) have results posted.
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None of the 27 has an industry lead sponsor. The 10 most frequent:
Daacro is the lead sponsor of 4 studies on the registry; none are open to participants now.
Daacro has 2 studies filed under Stress, Psychological — fewer than ten, so there is no comparison to draw.
1 of the studies in Stress, Psychological with a site in Germany that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07607808University Hospital, AachenPsychological Stress and Support Needs of Volunteer First Responders After Smartphone-based Cardiac Arrest Alerts | 2027-05-01 |
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Among the 27 studies in Stress, Psychological with a site in Germany, from their registry updates:
Nothing recorded among them since 2026-09-25.
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The aim of this study is to assess whether intake of Glycine (MSG) leads to an increase of cognitive performance after an acute stressor compared to placebo. One group will receive verum, one group placebo and one group will not receive any intervention. Cognitive testing will be performed in connection with the Trier Social Stress Test (TSST).
Stress can enhance or impair memory performances depending on the timing of the stressor and the timing of the memory processes in relation to the stressor. If stress occurs directly before or during the retrieval of information, the performance is impaired. Decreased performances using an acute stressor were also observed for other domains of cognitive functioning like working memory, interference control, cognitive flexibility and attention tasks.
Glycine, the simplest of the amino acids, is an essential component of important biological molecules, a key substance in many metabolic reactions, the major inhibitory neurotransmitter in the spinal cord and brain stem, and an anti-inflammatory, cytoprotective, and immune modulating substance. Studies have found positive effects of Glycine on episodic memory retrieval and in a word retrieval task.
To assess the effect of Glycine (MSG) on cognitive performance after an acute stressor, subjects perform baseline cognitive testing before intake of investigational products (Glycine (MSG), placebo or nothing) and participation in a stress test (Trier Social Stress Test - TSST). After the TSST stress-induced changes in cognitive performance are assessed. A second treatment intake takes place between the first and the remaining cognitive tests.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Microencapsulated Sublingual Glycine (MSG): 1 tablet prior to TSST; 1 tablet after the TSST
Dietary Supplement: Microencapsulated Sublingual Glycine (MSG)
Lactose: 1 tablet prior to TSST; 1 tablet after the TSST
Dietary Supplement: Placebo
Glycine (MSG) tablet
Also known as: Bidicin
Lactose tablet manufactured to mimic Glycine (MSG) tablet
Delayed memory performance after the TSST (correct words)
Efficacy of the intake of Glycine (MSG) on performance in the Verbal Learning and Memory Test (VLMT) delayed recall task (number of correct words) compared to placebo and control group
Time frame: 20 minutes after second product intake
Delayed memory performance before and during the TSST
Efficacy of the intake of Glycine (MSG) on performance in the Verbal Learning and Memory Test (VLMT) delayed recall task (number of correct words, number of perseverations and wrong words) compared to placebo and control group
Time frame: 15 minutes before and 42 minutes after first product intake
Immediate memory performance before and after the TSST
Efficacy of the intake of Glycine (MSG) on Performance in the Verbal Learning and Memory Test (VLMT) immediate recall task (number of correct words, decreased number of perseverations and wrong words) compared to placebo and control group
Time frame: 44 minutes before, 13 and 48 minutes after first product intake
VAS stress
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute stress compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
VAS anxiety
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute anxiety compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
VAS insecurity
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute insecurity compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
VAS sleepiness
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute sleepiness compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
VAS tension
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute tension compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
VAS lack of energy
Efficacy of the intake of Glycine (MSG) on subjective evaluation of acute lack of energy compared to placebo and control group measured on a Visual Analogue Scale (VAS). The VAS is a 10cm bipolar visual scale ranging from "not at all" to "highly". VAS scores are obtained by using a ruler and measuring the position of the participant's mark with millimeter precision. To control for possible variations due to printing, the total length of the line is also measured and percentage scores for each subject are computed. Percentage scores range from 0-100.
Time frame: 20 minutes, 37 minutes and 46 minutes after first product intake
STAI-state
Efficacy of the intake of Glycine (MSG) on state anxiety as measured by the State Trait Anxiety Inventory (STAI) compared to placebo and control group. The STAI-state measures anxiety as a temporary emotional state and comprises 20 items. Answers are given on a four-point rating scale ranging from 1 = "not at all" to 4 = "very true". Some STAI questions relate to the absence of anxiety, and are reversely scored. For analysis of the STAI-scale, items are combined in one scale, which then informs about state anxiety. The score range is 20-80; higher scores indicate more anxiety.
Time frame: 20 minutes and 46 minutes after first product intake
Systolic and diastolic blood pressure
Efficacy of the intake of Glycine (MSG) on blood pressure in response to the TSST compared to placebo and control group
Time frame: 25 minutes and 46 minutes after first product intake
Delayed memory performance after the TSST (perseverations, wrong words)
Efficacy of the intake of Glycine (MSG) on performance in the Verbal Learning and Memory Test (VLMT) delayed recall task (decreased number of perseverations and wrong words) compared to placebo and control group
Time frame: 20 minutes after second product intake
Cognitive performance before and after the TSST (Stroop)
Efficacy of the intake of Glycine (MSG) on performance in the Stroop test (speed and accuracy) compared to placebo and control group
Time frame: 10 minutes before first product intake and 23 minutes after second product intake
Cognitive performance before and after the TSST (CogTrack)
Efficacy of the intake of Glycine (MSG) on performance in attention, working memory, learning and recognition tasks of CogTrack compared to placebo and control group
Time frame: 40 minutes before first product intake, immediately after second product intake
Heart rate
Efficacy of the intake of Glycine (MSG) on heart rate in response to the TSST compared to placebo and control group
Time frame: Continous measurement starting 10 minutes after first product intake and ending 10 minutes after second product intake
Salivary Cortisol
Efficacy of the intake of Glycine (MSG) on salivary cortisol raw values in response to the TSST compared to placebo and control group
Time frame: 45, 10 minutes before first product intake, 28, 46, 55 minutes after first product intake, 10, 20, 35 and 50 minutes after second product intake
TICS
Do Trier Inventory for Chronic Stress (TICS) scores differ between groups? The TICS includes 57 items. Stress chronicity is measured by the frequency of stressful events perceived retrospectively within the last 3 months. Answers are given on a five-point rating scale, where 0 resembles "never" and 4 "very often". For analysis the questionnaire items are assigned to 10 scales: Work overload (range 0-32), Social overload (0-24), Pressure to succeed (0-36), Work dissatisfaction (0-32), excessive demands at work (0-24), Lack of social recognition (0-16), Social stress (0-24), Social isolation (0-24) and Chronic worrying (0-16); the last scale presents a Screening scale for chronic stress (0-48). Scores are obtained by summing up the values of the scale specific questionnaire items.
Time frame: Baseline
STAI-trait
Do State Trait Anxiety Inventory (STAI) trait scores differ between groups? The STAI-trait measures anxiety as a personality trait and comprises 20 items. Answers are given on a four-point rating scale ranging from 1 = "almost never" to 4 = "almost always". Some STAI questions relate to the absence of anxiety, and are reversely scored. For analysis of the STAI-scale, items are combined in one scale, which then informs about trait anxiety. The score range is 20-80; higher scores indicate more anxiety.
Time frame: Baseline
Mental arithmetic performance during the TSST
Efficacy of the intake of Glycine (MSG) on arithmetic performance compared to placebo and control group. One part of the Trier Social Stress Test (TSST) is a mental arithmetic task. The subject is asked to stepwise subtract 17 from 2023 as quickly and correctly as possible. Performance will be measured by counting how many numbers the subject enumerates and how many times the subject has to restart. Furthermore, the lowest correct number and the shortest run will be recorded.
Time frame: 37.5 minutes after first product intake
eCB levels
Exploration of endocannabinoid levels (eCB)
Time frame: 45, 10 minutes before first product intake, 28, 46, 55 minutes after first product intake, 10, 20, 35 and 50 minutes after second product intake
Blood Glucose levels
Exploration of blood glucose levels
Time frame: 75 minutes before first product intake, 25 and 46 minutes after first product intake
Plan to share: No
Ran from Nov 2017 to primary completion in Mar 2018, 4 months.
Of 459 non-industry interventional studies with no phase under Stress, Psychological, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 26. This study's 4 months is below that.
Counting every sponsor, half of 472 studies reached it within 13 months; a quarter within 5 and three quarters within 26.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2018. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Sodium Glutamate
Daacro