An observational study in Delirium, Cognitive Impairment and Cognitive Decline, sponsored by Ciusss de L'Est de l'Île de Montréal. Terminated at 1 site in Canada. Open to participants aged 70 Years and older. Per ClinicalTrials.gov, last updated 2021-10-08.
Sponsored by Ciusss de L'Est de l'Île de Montréal · Observational
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Among 16 studies in Emergence Delirium with a site in Canada — 5 open to participants now, 6 under way, none of them phase 3. Emergence Delirium · Canada.
Among the 16 studies in Emergence Delirium with a site in Canada, this one is one of 2 that started in 2017, is one of 4 observational ones, and was the 5th registered.
752 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
Browse Emergence Delirium studies →5 of the 16 studies in Emergence Delirium with a site in Canada are open now. Recruiting first, the newest first:
McGill University Health Centre/Research Institute of the McGill University Health Centre · Sites in Canada
Ages 18+
Sunnybrook Health Sciences Centre · Sites in Canada
Ages 60+
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Sites in Canada
Ages 65–100
University of British Columbia · Sites in Canada
Ages 18+
University of British Columbia · Sites in Canada
Ages 61+
A study can be open while its sites in Canada have not opened yet or have stopped. Only those recruiting at a site in Canada →
Of the 143 Emergence Delirium studies recruiting now, 79 (55%) set no upper age limit and 44 (31%) stop at 75 or younger; 34 take children under 18; 24 take healthy volunteers.
This study: 70 Years and older · all sexes · no healthy volunteers.
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16 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 2 started in 2017.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 23 is below the median of 164 across 278 observational studies indexed under Emergence Delirium.
Median enrollment 199 across the 12 interventional studies, 72 across the 4 observational. Of the 7 that completed or were terminated, 0 (0%) have results posted.
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None of the 16 has an industry lead sponsor. The 10 most frequent:
Ciusss de L'Est de l'Île de Montréal is the lead sponsor of 90 studies on the registry; 32 are open to participants now.
Ciusss de L'Est de l'Île de Montréal has 1 study filed under Emergence Delirium — fewer than ten, so there is no comparison to draw.
3 of the studies in Emergence Delirium with a site in Canada that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07051096University of British ColumbiaResponsive Nature-Driven Imagery to Reduce Delirium After Cardiac Surgery | 2026-12 |
| NCT06648681University of British ColumbiaLemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients | 2027-04-30 |
| NCT06613178McGill University Health Centre/Research Institute of the McGill University Health CentreIntravenous Acetaminophen After Cardiac Surgery - Definitive Study | 2027-07-01 |
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Among the 16 studies in Emergence Delirium with a site in Canada, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The purpose of this study is to determine what percentage of patients have cognitive problems (for example, memory or concentration difficulties) after surgery and anesthesia, what the characteristics of these problems are, and whether they persist over time. In particular, the investigators want to study this in the French-speaking Quebec population with cognitive evaluation tools adapted for this population.
Multiple experimental and observational studies have established that a non-negligible percentage of individuals undergoing surgery and anesthesia will experience a postoperative decline in mental abilities. These cognitive changes can range from postoperative delirium to more subtle and longer lasting (weeks to months) impairments; these latter changes are often referred to in the literature as postoperative cognitive dysfunction (POCD). While the precise causes of POCD remain nebulous, a clear epidemiological risk factor is advanced age - a demographic group that accounts for an increasing percentage of elective surgeries in North America. Several RCTs have attempted to link specific aspects of anesthesia, such as depth of anesthesia, regional vs general anesthesia, hemodynamic parameters, specific anesthetic agents, etc., to the risk of developing POCD in both the elderly and general populations. Results have often been conflicting and, based on current evidence, it is difficult to identify any specific anesthetic strategy that clearly reduces the risk of POCD. The present study aims to establish the incidence and neuropsychological characteristics of POCD in the investigator's local patient population as well as to establish the feasibility of pre- and postoperative cognitive testing with assessment tools adapted to and validated for Quebec francophones in order to lay the groundwork for future studies by the research group of interventions targeting specific anesthetic techniques and monitoring modalities.
752 studies on the registry are indexed under Emergence Delirium; 262 are open to participants now.
This study's enrollment of 23 is below the median of 164 across 278 observational studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Ciusss de L'Est de l'Île de Montréal is the lead sponsor of 90 studies on the registry; 32 are open to participants now.
Compared within Emergence Delirium, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Delirium. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Elderly Quebec francophone patients undergoing elective major non-cardiac surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults 70 years of age or older undergoing major noncardiac surgery under protocolized general anesthesia
Procedure: Protocolized general anesthesia
Induction and maintenance of general anesthesia, post-operative analgesia with protocolized drugs and doses. Maintenance of MAP +/- 20% of baseline with vasopressors as needed.
Post-operative cognitive dysfunction
Presence of post-operative cognitive dysfunction as determined by neuropsychological tests. A diagnosis of POCD will be made under the follow circumstances: a) A decrease in score from one assessment to the next (e.g., postoperatively vs. preoperatively) that results in the subject changing from within normal limits to below normal limits on the Montreal Cognitive Assessment (MoCA) b) A decrease in score of ≥ 1 standard deviation on the normed tests (MoCA, verbal fluency
Time frame: Baseline cognitive testing will be performed before surgery, then repeated on day before discharge or post-operative day 7 and then again at approximately post-operative day 30.
Post-operative delirium
Participants will be assessed for delirium via administration of the Confusion Assessment Method
Time frame: Post-operative days 1 and 2
Self-assessment of applied cognitive abilities
The PROMIS self-assessment questionnaire "Applied cognition - Abilities" will be administered
Time frame: Pre-operatively, then post-operatively on day before discharge or post-operative day 7, then again on approximately post-operative day 30
Plan to share: No
Ran from Sep 2017 to primary completion in Sep 2021, 48 months.
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This study is terminated, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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Ciusss de L'Est de l'Île de Montréal