An observational study in Asphyxia Neonatorum, sponsored by University Children's Hospital, Zurich. Completed at 1 site in Switzerland. Open to participants aged 1 Day to 4 Days. Per ClinicalTrials.gov, last updated 2017-09-21.
Sponsored by University Children's Hospital, Zurich · Observational
The histology of the placenta of newborn infants with perinatal asphyxia and hypoxic-ischaemic encephalopathy is analysed. There will be an evaluation if placenta could be a biomarker for neurodevelopmental outcome at 18-24 months of age.
All newborn infants with a gestational Age >35 weeks, fulfilling the inclusion criteria of perinatal asphyxia and hypoxic-ischaemic encephalopathy, born in Switzerland and treated in the University Hospital of Zurich with hypothermia therapy after birth
Inclusion Criteria:all newborn infants with APGAR \<5 at 10minutes, pH\<7.0, lactate >12mmol/L, base excess >16, resuscitation >10min after birth, gestational age >35 weeks and an encephalopathy -
Exclusion Criteria:
-
newborn infants with hypoxic-ischaemic encephalopathy are cooled for 72 hours with a target temperature of 33-34°C (whole body cooling).
neurodevelopmental outcome at 18-24 month of Age
The investigators will analyse if there is a correlation of placenta histology and neurodevelopmental outcome
Time frame: 7 years
Plan to share: No
No publications or documents are linked to this record.
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University Children's Hospital, Zurich