An observational study in Ultrasonography, Carotid Stenosis and Ischemic Stroke, sponsored by Seoul National University Hospital. Status unknown at 1 site in Korea, Republic of. Open to participants aged 20 Years and older. Per ClinicalTrials.gov, last updated 2017-09-14.
Sponsored by Seoul National University Hospital · Observational
Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque. Plaque enhancement with CEUS showed correlation with the histologic density of neovessels within the carotid plaque and the previous cardiovascular events. Vulnerable plaques with a high risk of thromboembolic complications and rapid progression is associated with acute ischemic stroke. The prognostic value of vulnerable carotid artery plaque depicted with CEUS has not been fully investigated. The purpose of this study is to define prognostic value of plaque enhancement on carotid CEUS in acute stroke patients. Research question is; in acute ischemic stroke patients with ipsilateral carotid plaque as probable etiology of stroke, is the presence of carotid plaque enhancement on CEUS independent predictor of future stroke.
Hospitalized acute ischemic stroke patients with ipsilateral carotid artery stenosis.
Exclusion Criteria:
Composite of recurrent stroke, vascular death and myocardial infarction
(1) recurrent stroke: newly appeared DWI positive lesion on brain MRI with corresponding neurologic symptom (2) vascular death: sudden death, death due to stroke, myocardial infarction, heart failure, arrhythmia, pulmonary embolism, systemic bleeding, or ischemia of organ. (3) myocardial infarction: at least two of the followings: ① a history of typical angina pain. ② Elevation of Troponin, ③ Newly developed ST change or Q waves or LBBB on ECG (outcomes will be measured by chart review or physician diagnosis or telephone interview)
Time frame: 12 months
Ipsilateral stroke
Recurrent stroke of ipsilateral side (recurrent stroke at same side of previous infarction)
Time frame: 12 months
All-cause mortality
All of the deaths, regardless of the cause
Time frame: 12 months
Carotid intervention
Ipsilateral carotid endarterectomy or carotid artery stent insertion which was not planned when discharge.
Time frame: 12 months
Plan to share: Undecided
No publications or documents are linked to this record.
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Seoul National University Hospital