CClinicalTrials.gg
Status unknownNCT03281915Updated Sep 13, 2017

the Effect of Different Modialites of Varicocelectomy on Semen Parameters in Patient With Normal Semen Analysis

An observational study in Varicocele, sponsored by Assiut University. Status unknown at 1 site in Egypt. Open to male participants aged 19 Years to 45 Years. Per ClinicalTrials.gov, last updated 2017-09-13.

Sponsored by Assiut University · Observational

The sponsor has not verified this record recently (last verified Sep 2017), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
32
Ages
19 Years to 45 Years
Sex
Male
01

Study summary

to evalute the effect inguinal and subinguinal approach of varicoceclectomy on semen parameter for patients complaining of varicocele with normal semen parameter (pain is the main complaint)

Read the detailed description

the varicocele is defined as dilated and incompetent veins within the pampiniform plexus of spermatic cord. varicocele has been described as the most common surgically correctable cause of male subinfertility.this is a disease that devolops during puberty when both endocrine and exocrine function of the testicle dramatically increases, along with testicular blood flow. varicocele only rarely detected in boys less than 10 years. left sided varicocle found in 15% of healthy young men.incontrast, the incidence in sub fertile men approaches 40% bilateral varicocele is uncommon in healthy men (less than 10%) but palpated in 20% in sub fertile men. in-general varicocele don't spontaneously regress. an accurate physical examination remain the corner stone of varicocele diagnosis.

several anatomic features contribute to the predominance of left sided varicocele is the left intrnal spermatic vein longer than the right and it typically joins the left renal vein at a right angle.as result of this character higher venous pressures fair transmited to the left spermatic vein and result in reterograde reflux of blood.

varicocle are associated with testicular atrophhy and varicocle correction can reverse atrophy in adolececnt. there is strong evidence affect semen quality it can cause abnormalties in concentration, motility and morphology.main defect is the motility.

indication of varicocelectomy:

  1. Large varicoceles in adolescents
  2. Childhood varicocele with testicular atrophy
  3. Varicoceles with elevated FSH values, or low testosterone levels
  4. Varicoceles with scrotal pain
  5. Cosmetic indication
  6. Male infertility with pathological semen analysis and varicocele
02

Conditions studied

  • Varicocele

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Keywords

  • infertility
  • pain
  • pregnancy
03

Who can participate

Ages eligible
19 Years to 45 Years
Sexes eligible
Male
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Male patients undergoing varicocelectomy while having normal semen parameters (doing surgery for other reasons eg. pain)

Inclusion criteria

  • age more than 19 years old
  • primary varicocele

Exclusion criteria

Exclusion Criteria:

  • secondary varicocele recurrent varicocele age less than 19 years
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
32 participants (estimated)
Patient registry
No

Groups and cohorts

  • high inguinal approch

    Patients undergoing high inguinal varicocelectomy with normal pre operative semen parameters, post operative semen analysis parameters will be recorded

    Procedure: High inguinal Varicocelectomy

  • subinguinal approch

    Patients undergoing subinguinal varicocelectomy with normal pre operative semen parameters, post operative semen analysis parameters will be recorded

    Procedure: Subinguinal varicocelectomy

Interventions

  • ProcedureHigh inguinal Varicocelectomy

    Semen parameters after high inguinal varicocelectomy will be collected

  • ProcedureSubinguinal varicocelectomy

    Semen parameters after subinguinal Varicocelectomy will be collected

05

What researchers measure

Primary outcomes

  1. Semen analysis

    Motility morphology concentration

    Time frame: 3months

06

Study locations

1 site
07

References and documents

Publications

  • Leslie SW, Sajjad H, Siref LE. Varicocele. 2023 Nov 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK448113/ PubMed 28846314 ↗
  • Wu X, Liu Q, Zhang R, Wang W, Gao Y. Therapeutic efficacy and safety of laparoscopic surgery versus microsurgery for varicocele of adult males: A meta-analysis. Medicine (Baltimore). 2017 Aug;96(34):e7818. doi: 10.1097/MD.0000000000007818. PubMed 28834886 ↗
  • Canning DA. Re: Sperm Concentration and Forward Motility are Not Correlated with Age in Adolescents with an Idiopathic Varicocele and Symmetrical Testicular Volumes. J Urol. 2017 Sep;198(3):472. doi: 10.1016/j.juro.2017.06.068. Epub 2017 Jun 20. No abstract available. PubMed 28817895 ↗
  • Schmidt B. Membranes in artificial organs. Artif Organs. 1996 May;20(5):375-80. doi: 10.1111/j.1525-1594.1996.tb04519.x. PubMed 8725614 ↗
  • Sedaghatpour D, Berookhim BM. The Role of Varicocele in Male Factor Subfertility. Curr Urol Rep. 2017 Sep;18(9):73. doi: 10.1007/s11934-017-0713-8. PubMed 28718159 ↗
08

Registry details

Key details

Study ID
NCT03281915
Lead sponsor
Assiut University
Responsible party
Abdelrahman Mohamed Abdelkader (Resident, Assiut University) — Principal investigator
First posted
Sep 13, 2017
Start date
Oct 15, 2017 (estimated)
Primary completion
Oct 15, 2018 (estimated)
Completion
Oct 15, 2018 (estimated)
Last update
Sep 13, 2017

Study contacts

Abdelrahman M Abdelkader
Contact
abdelrahmanmohamed.aa@gmail.com
01068336396
Mohamed A Osman, professor
Contact
osman@aun.edu.eg
01062226639 ext. 0882315760
Ehab O Ahmed
study director · unaffiliation
Mohamed I Taha
study chair · unaffiliation
Ahmed k mohamed
study director · unaffiliation

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is status unknown, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

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