CClinicalTrials.gg
CompletedNCT03269110Updated Apr 18, 2025

Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)

An observational study in Autism Spectrum Disorder, Asthma and Executive Dysfunction, sponsored by Ottawa Hospital Research Institute. Completed at 58 sites in 4 countries. Open to participants aged 4 Years to 6 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-04-18.

Sponsored by Ottawa Hospital Research Institute · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
664
Ages
4 Years to 6 Years
Sex
All
01

Study summary

FACT 4 Child is a follow up study of mothers who participated in the Folic Acid Clinical Trial (NCT01355159) and their children at 4-6 years of age to determine the effect of high dose folic acid supplementation on social impairments associated with Autism Spectrum Disorders (ASDs), and deficiencies in a range of executive function and emotional and behavioural problems in young children, and the risk of death.

Read the detailed description

The Folic Acid Clinical Trial (FACT) was developed to conclusively determine the effect of high dose folic acid supplementation in pregnancy on the prevention of preeclampsia in a randomized controlled trial (RCT) design.

The primary objective of the FACT 4 Child study is to examine the effect of maternal folic acid supplementation in pregnancy on the risk of social impairments, as well as executive function, emotional and behavioural problems associated with Autism Spectrum Disorders (ASD) and other developmental disorders, and death in offspring aged 4-6 y of mothers recruited to the CIHR funded FACT.

The effect of folic acid supplementation throughout pregnancy may potentially have an impact on both the mother and her offspring, which highlights the importance and relevance of this study to the management of women with preeclampsia. Results of this study will allow care providers to have the evidence of potential effects of high dose folic acid that can then be discussed; allowing women to make an informed choice about their management and care.

02

Conditions studied

  • Autism Spectrum Disorder
  • Asthma
  • Executive Dysfunction
  • Emotional Problem
  • Behavioural Problem
  • Pre-Eclampsia
  • Death

Keywords

  • neurological
  • autism
  • ASD
  • behaviour
  • folic acid
  • pre-eclampsia
  • asthma
  • executive function
03

Who can participate

Ages eligible
4 Years to 6 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

FACT 4 Child is the post-delivery follow-up of offspring born to FACT mothers once children reach the age of 4 years. Women in FACT and their children, will be invited to participate in FACT 4 Child.

Inclusion criteria

  1. Capability of participant to comprehend and comply with study requirements
  2. Mother participated in FACT

Exclusion criteria

Exclusion Criteria:

  1. Confirmed spontaneous termination (miscarriage) or elective termination or stillborn
  2. Confirmed death of offspring at 6 weeks postpartum and/or at discharge from hospital
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
664 participants (actual)
Patient registry
No

Groups and cohorts

  • Mother and child(ren)

    FACT 4 Child is the post-delivery follow-up of the offspring born to FACT mothers once these children are between the age of 4 - 6 years.

    Diagnostic Test: SRS 2, CBCL, BRIEF-P

Interventions

  • Diagnostic testSRS 2, CBCL, BRIEF-P

    This study does not involve an intervention.

05

What researchers measure

Primary outcomes

  1. Neurocognitive disability

    The primary outcome is a competing composite endpoint of neurocognitive disability and death. Neurocognitive disability is a composite outcome related to social impairments, executive function, emotional and behavioural problems which have been associated with Autism Spectrum Disorder (ASD). It will be defined by an abnormal score on any of three standardized and validated assessment tools: SRS-2 BRIEF-P, or CBCL which will be administered to the parents of children aged 4-6 years. Deaths reported between 6 weeks to 4-6 years of age will be recorded as a competing event and treated as part of the primary endpoint.

    Time frame: From six weeks of age to date of data collection taken at one time point between the ages of 4 to 6 years.

Secondary outcomes

  1. Severe Morbidity

    Secondary outcomes to be assessed in FACT 4 Child include severe morbidity of FACT offspring, captured by the Mother-Child Health Survey at the age of 4 - 6 years, including incidence of: Severe morbidity defined by any illnesses during the previous years that has necessitated hospitalization or medication/treatment for \>2 months

    Time frame: From six weeks of age to date of data collection taken at one time point between the ages of 4 to 6 years.

06

Study locations

58 sites
  • Nepean
    Penrith, New South Wales 2750, Australia
  • Townsville
    Douglas, Queensland 4814, Australia
  • Ipswich
    Ipswich, Queensland 4305, Australia
  • Women's and Children's Hospital
    Adelaide, South Australia, Australia
  • Royal Women's
    Parkville, Victoria 3052, Australia
  • Sunshine
    St Albans, Victoria 3021, Australia
  • Calgary Foothills Medical Center
    Calgary, Alberta T2N2T9, Canada
  • Edmonton Lois Hole Hospital for Women
    Edmonton, Alberta T5H 3V9, Canada
  • St-Paul's Hospital
    Vancouver, British Columbia V6Z 2K5, Canada
  • Winnipeg University of Manitoba
    Winnipeg, Manitoba R3E 3P4, Canada
  • Fredericton Dr. Everett Chalmers Regional Hospital
    Fredericton, New Brunswick E3B 5N5, Canada
  • Moncton Hospital
    Moncton, New Brunswick E1C 6Z8, Canada
  • St-John's Women's Health Centre
    St John's, Newfoundland and Labrador A1B 3V6, Canada
  • Hamilton McMaster University
    Hamilton, Ontario L8S 4K1, Canada
  • Kingston
    Kingston, Ontario K7L 2V7, Canada
  • London
    London, Ontario N6A 5W9, Canada
  • The Ottawa Hospital, General Campus
    Ottawa, Ontario K1H 8L6, Canada
  • The Ottawa Hospital, Civic Campus
    Ottawa, Ontario K1Y 4E9, Canada
  • Sunnybrook Health Sciences
    Toronto, Ontario M4N 3M5, Canada
  • Quebec City (CHUL) Centre Hospitalier Universitaire
    Montreal, Quebec G1V 4G2, Canada
  • Sainte-Justine
    Montreal, Quebec H3T 1C5, Canada
  • St-Mary's Hospital
    Montreal, Quebec H3T 1M5, Canada
  • St-Luc
    Montreal, Quebec, Canada
  • Regina Qu'Appelle Health Region
    Regina, Saskatchewan S4P 0W5, Canada
  • University of West Indies
    Kingston 7, Jamaica
  • Jubilee
    Kingston, Jamaica
  • Spanishtown
    Kingston, Jamaica
  • Hinchingbrooke
    Huntingdon, Cambridgeshire PE29 6NT, United Kingdom
  • Leighton
    Crewe, Cheshire CW1 4QJ, United Kingdom
  • Darlington Memorial Hospital
    Darlington, County Durham DL3 6HX, United Kingdom
  • Fairfield
    Bury, Lancashire BL9 7TD, United Kingdom
  • Rochdale
    Rochdale, Lancashire OL12 0NB, United Kingdom
  • Lincolnshire
    Lincoln, Lincolnshire LN2 4AX, United Kingdom
  • West Middlesex University Hospital
    Isleworth, Middlesex TW7 6AF, United Kingdom
  • Wansbeck General Hospital
    Ashington, Northumberland NE63 9JJ, United Kingdom
  • St George's Hospital
    London, Tooting SW17 0QT, United Kingdom
  • Gateshead Queen Elizabeth Hospital
    Gateshead, Tyne And Wear NE9 6SX, United Kingdom
  • South Tyneside Distrcit Hospital
    South Shields, Tyne And Wear NE34 0PL, United Kingdom
  • Blackburn
    Blackburn, BB2 3HH, United Kingdom
  • Burnley
    Burnley, BB10 2PQ, United Kingdom
  • Cumberland Infirmary Carlisle
    Carlisle, United Kingdom
  • North Manchester
    Crumpsall, M8 5RB, United Kingdom
  • North Durham
    Durham, United Kingdom
  • Guy's and St. Thomas
    London, United Kingdom
  • South Tees Hospital
    Middlesbrough, TS4 3BW, United Kingdom
  • Newcastle upon Tyne Hospitals
    Newcastle upon Tyne, NE1 4LP, United Kingdom
  • North Tyneside General Hospital
    North Shields, NE29 8NH, United Kingdom
  • Norfolk & Norwich
    Norwich, United Kingdom
  • Nottingham City Hospital
    Nottingham, NG5 1PB, United Kingdom
  • Nottingham Queens Medical Centre
    Nottingham, NG7 2UH, United Kingdom
  • Oldham
    Oldham, OL1 2JH, United Kingdom
  • North Tees Hospital
    Stockton, TS19 9AH, United Kingdom
  • Sunderland Royal Hospital
    Sunderland, SR4 7TP, United Kingdom
  • Hillingdon Hospital
    Uxbridge, UB8 3NN, United Kingdom
  • Warrington Hospital
    Warrington, United Kingdom
  • West Cumberland Hospital
    Whitehaven, United Kingdom
  • 49 Marine Avenue
    Whitley Bay, United Kingdom
  • Royal Wolverhampton - New Cross Hospital
    Wolverhampton, United Kingdom
07

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Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03269110
Lead sponsor
Ottawa Hospital Research Institute
Responsible party
Sponsor
First posted
Aug 31, 2017
Start date
Jul 1, 2017
Primary completion
Dec 31, 2023
Completion
Dec 31, 2023
Last update
Apr 18, 2025

Study contacts

Mark Walker, MD
principal investigator · The Ottawa Hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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