An interventional study of identification of genetic factors in Cleft Lip and Palate, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Per ClinicalTrials.gov, last updated 2026-05-13.
Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Basic science
Despite significant progress made in identification on numerous genes and gene pathways critical for craniofacial development, several approaches, ie mutation screening of specific candidates, association studies and even genome-wide scans have largely failed to reveal the molecular basis of NS human clefting
Despite significant progress made in identification on numerous genes and gene pathways critical for craniofacial development, several approaches, ie mutation screening of specific candidates, association studies and even genome-wide scans have largely failed to reveal the molecular basis of NS human clefting. Moreover, the efficiency of Whole Exome Sequencing -WES- was proven. The efficiency of WES was proven by the identification of the genes causing Freeman Sheldon and Miller's syndrome, followed by several others. In the Picardy region, management and follow-up of orofacial cleft patients are well-organised by a multidisciplinary team in the university hospital of Amiens. The investigators therefore decided to perform whole exome sequencing (WES) on precisely phenotyped non-syndromic CL/P patients followed in our center.
168 studies on the registry are indexed under Cleft Lip; 51 are open to participants now.
This study's planned enrollment of 30 is close to the median of 30 across 116 interventional studies indexed under Cleft Lip.
Browse Cleft Lip studies →Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.
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Exclusion Criteria:
Clinical questionnaire and analysis of genetic data obtained by exome high-throughput sequencing
Genetic: identification of genetic factors
Clinical questionnaire and analysis of genetic data obtained by exome high-throughput sequencing
Identification of genetic factors
Identification of genetic factors implicated in orofacial cleft using whole exome sequencing (WES).
Time frame: Day 1
Started Nov 2016 (actual). Primary completion is estimated for Nov 2027, 132 months after the start.
Of 64 non-industry interventional studies with no phase under Cleft Lip, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 15 and three quarters within 33. This study's planned 132 months is above that.
Counting every sponsor, half of 65 studies reached it within 22 months; a quarter within 15 and three quarters within 33.
How these figures are worked out, and which studies are left out of them.
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Centre Hospitalier Universitaire, Amiens →