An interventional study of Anesthesia induction and Anesthesia maintenance in Multimodal Analgesia, Tramadol and Enhanced Recovery After Surgery, sponsored by Centre Hospitalier Universitaire, Amiens. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Centre Hospitalier Universitaire, Amiens · Not applicable, Interventional, and Other
Tramadol is commonly used postoperatively due to its ease of administration, but it carries several risks, including interindividual variability, drug interactions, neuropsychiatric risks in elderly patients, and long-term dependence. Although its analgesic efficacy is comparable to that of strong opioids, its role in a multimodal analgesia strategy remains insufficiently studied. Research tailored to current clinical practices is needed to accurately assess its tolerance profile.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's planned enrollment of 140 is above the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Centre Hospitalier Universitaire, Amiens is the lead sponsor of 586 studies on the registry; 185 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Anesthesia induction · Other: Anesthesia maintenance · Other: Multimodal analgesia · Drug: Morphine
Other: Anesthesia induction · Other: Anesthesia maintenance · Other: Multimodal analgesia · Drug: Tramadol
Anesthesia induction with Propofol, Ketamine, Sufentanil, Lidocaine, and Dexamethasone
Anesthesia maintenance with Sevoflurane, Sufentanil, and Lidocaine
Multimodal analgesia with Paracetamol, Ketoprofen, and Nefopam.
Morphine titration 2mg/5min if actual weight \<50kg, 3mg/5min if actual weight≥50kg if NRS≥3/10 despite administration of paracetamol, ketoprofen and nefopam in recovery room. Oral intake on return to the surgical ward with morphine 10 mg every 4 hours if actual weight ≥50 kg, 5 mg every 4 hours if weight \<50 kg, if NRS ≥3/10 despite administration of paracetamol, ketoprofen, and nefopam.
Tramadol: 100 mg every 6 hours if actual weight ≥50 kg, 50 mg every 6 hours if weight \<50 kg, if NRS ≥3/10 despite administration of paracetamol, ketoprofen, and nefopam Oral intake on return to the surgical ward at the same doses
Score validated in French QoR-15
Score validated in French QoR-15
Time frame: at 24 hours
QoR-15 questionnaire score
QoR-15 questionnaire score
Time frame: at 48 hours
QoR-15 questionnaire score
QoR-15 questionnaire score
Time frame: at 72 hours
Mean scores (0-10) for postoperative pain
Mean scores (0-10) for postoperative pain in the PACU
Time frame: at 24 hours
Mean scores (0-10) for postoperative pain
Mean scores (0-10) for postoperative pain in the PACU
Time frame: at 48 hours
Mean scores (0-10) for postoperative pain
Mean scores (0-10) for postoperative pain in the PACU
Time frame: at 72 hours
Consumption of opioids in morphine equivalent per os
Consumption of opioids in morphine equivalent per os
Time frame: at 24 hours
Consumption of opioids in morphine equivalent per os
Consumption of opioids in morphine equivalent per os
Time frame: at 72 hours
Analgesic efficacy
Analgesic efficacy after administration of an opioid assessed by NRS (0-10) 2 hours after administration of the opioid
Time frame: 2 hours
Length of stay in the postoperative intensive care unit in minutes
Length of stay in the postoperative intensive care unit in minutes
Time frame: up to 72 hours
length of post-operative hospitalisation in days
length of post-operative hospitalisation in days
Time frame: up to 72 days
Number of occurrences of nausea/vomiting, ileus, hypoxaemia, pruritus, confusion (CAM tool) after opioid administration
Number of occurrences of nausea/vomiting, ileus, hypoxaemia, pruritus, confusion (CAM tool) after opioid administration
Time frame: up to 72 hours
Score of satisfaction with pain management
Score of satisfaction with pain management, assessed on a numerical scale from 0-10 (0 total dissatisfaction, 10 total satisfaction) at discharge from hospital
Time frame: up to 72 hours
Number of patients taking opioids daily
Number of patients taking opioids daily at 1 months after hospital discharge. Assessment of risk of misuse: POMI-5F scale.
Time frame: at 1 month
Number of patients taking opioids daily
Number of patients taking opioids daily at 3 months after hospital discharge. Assessment of risk of misuse: POMI-5F scale.
Time frame: at 3 months
Number of patients with chronic postoperative pain
Number of patients with chronic postoperative pain 3 months after surgery
Time frame: at 3 months
Plan to share: No
No publications or documents are linked to this record.
Started Dec 2025 (actual). Primary completion is estimated for Apr 2028, 28 months after the start.
Of 2,089 non-industry interventional studies with no phase under Pain, Postoperative, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 23. This study's planned 28 months is above that.
Counting every sponsor, half of 2,102 studies reached it within 11 months; a quarter within 6 and three quarters within 23.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Studies of the drug tested here: Morphine
Centre Hospitalier Universitaire, Amiens →