A Phase 1/2 interventional study of Heparin in Thromboprophylaxis and Thoracic Surgery, sponsored by West China Hospital. Status unknown at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2016-10-24.
Sponsored by West China Hospital · Phase 1/2, Interventional, and Prevention
Thromboembolism is an important perioperative complication in major thoracic surgery, even though current guidelines have recommended postoperative administration of heparin or LMWH for thromboprophylaxis for those high-risk patients, there are still many cases of thromboembolism. Therefore, as the guideline itself writes, the investigators believe the rational of dose and timing of heparin in thoracic surgery are still not well established. Therefore, the investigators aimed to conduct this randomized controlled study to explore the safety and efficacy of preoperative Administration of Heparin as Thromboprophylaxis in Major Thoracic Surgery.
386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.
This study's planned enrollment of 2,000 is above the median of 84 across 198 interventional studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →West China Hospital is the lead sponsor of 483 studies on the registry; 240 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
start heparin sodium (5000IU, BID) upon admission, and continue until discharge
Drug: Heparin
start heparin sodium (5000 IU,BID) from postoperative day 1, and continue until discharge
Drug: Heparin
intraoperative bleeding volume (ml)
During the operation, the blood loss of each patient was collected and measured, and recorded by the investigators.
Time frame: the bleeding volume (ml) during operation in the operation room for all patients
chest tube drainage volume (ml)
Time frame: from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy )
thromboembolism occurence rate (%)
Time frame: within 30 days after surgery
APTT (s)
Time frame: on postoperative day 1 for both group
PT(s)
Time frame: on postoperative day 1 for both group
INR
Time frame: on postoperative day 1 for both group
blood platlet count(/L)
Time frame: on postoperative day 1 for both group
chest tube drainage duration (days)
Time frame: from postoperative day 1 to chest tube remove(usually on postoperative day 3 for lobectomy or thymectomy,on postoperative day 7 for esophagectomy )
PT(s)
Time frame: rightly upon hospital admission day
APTT(s)
Time frame: rightly upon hospital admission day
INR
Time frame: rightly upon hospital admission day
blood platlet count(/L)
Time frame: rightly upon hospital admission day
Plan to share: Undecided
This study is status unknown, as verified in Oct 2016. You cannot join it, but the record below documents what was studied.
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West China Hospital