An observational study in Premature Birth, Obstructive Lung Disease and Bronchopulmonary Dysplasia, sponsored by St. Justine's Hospital. Completed. Open to participants aged 20 Years to 29 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-10.
Sponsored by St. Justine's Hospital · Observational
Preterm birth alters the normal sequence of lung development with lasting respiratory consequences. It is still unclear whether observed respiratory morbidities in preterm born individuals reflect sequelae from a non-progressive lung disease that occurred early in life or result from ongoing active disease that, if left undiagnosed and untreated, could increase the risk of a COPD-like phenotype. We propose to examine micro-structural abnormalities of the lung using innovative non-invasive imaging technologies in relation to pulmonary function and markers of inflammation and oxidative stress in young adults born preterm.
3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.
This study's planned enrollment of 50 is below the median of 157 across 929 observational studies indexed under Lung Diseases.
Browse Lung Diseases studies →St. Justine's Hospital is the lead sponsor of 155 studies on the registry; 27 are open to participants now.
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25 adults aged 20-29 born preterm (\<29 weeks); 25 sex and age-matched controls (friend or sibling).
Exclusion Criteria:
Lung parenchymal tissue density
Pulmonary hydrogen protons (1H) magnetic resonance imaging (MRI) using ultra-short echo time pulse sequences will be performed to quantify signal intensity (SI) as a surrogate of parenchymal tissue density.
Time frame: Baseline
Ventilation defect
Thoracic hyperpolarized 129Xe MRI to measure apparent diffusion coefficient (ADC) - subgroup of 10 participants (5 preterm, 5 control)
Time frame: Baseline
Pulmonary function - airflow limitation
Spirometry (FEV1/FVC) will be performed according to the American Thoracic Society guidelines
Time frame: Baseline
Pulmonary function - lung volumes
Lung volumes (RV/TLC) by plethysmography will be performed according to the American Thoracic Society guidelines
Time frame: Baseline
Pulmonary function - diffusion lung capacity
DLCO will be performed according to the American Thoracic Society guidelines
Time frame: Baseline
Pulmonary function - ventilation homogeneity
Lung clearance index by nitrogen washout will be performed according to the American Thoracic Society guidelines
Time frame: Baseline
Inflammatory and oxidative stress markers
Oxidative stress markers glutathione (GSH, GSSG; by capillary zone Electrophoresis) with calculation of Redox potential by the Nernst equation
Time frame: Baseline
Pneumoproteins SP-D
Surfactant protein D (plasma)
Time frame: Baseline
Pneumoproteins CCSP-16
CCSP-16 (plasma)
Time frame: Baseline
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2024. You cannot join it, but the record below documents what was studied.
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St. Justine's Hospital