An observational study in Aortic Dissection, sponsored by Central South University. Status unknown at 1 site in China. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2016-06-29.
Sponsored by Central South University · Observational
This study aims to investigate Serum Tenascin C levels in patients with acute symptoms relating to a known or newly diagnosed aortic aneurysm in emergency department and reveals the possible role of Tenascin C in the development of the disease.
Patients with acute and chronic aortic disease /survivors and non-survivors were compared. Further subgroup analysis on the characteristics of the aneurysm and patients were performed. The aneurysms (ruptured and dissected) were divided according to the style of the Stanford classification,according to the location of the pathology in aneurysms of the ascending thoracic aorta .the descending thoracic aorta, or the abdominal aorta.The subgroup were divided according to the extent of propagation of the disease (rupture,covered rupture, acute dissection, chronic dissection and ectasia). Rupture was defined by direct visualisation of the discontinuity of the aortic wall by computed tomography, sonography, intraoperative findings or at autopsy with detection of blood in the pleural, pericardial or abdominal cavity. Covert rupture was defined as an intramural haematoma without detection of free blood in the body cavities. Acute dissection was defined when blood separating the layers of the aortic media was newly diagnosed. Chronic dissection was defined as the absence of any visible propagation of a known dissection compared to preexisting examinations. Ectatic aneurysm was defined as a permanent localised dilatation of the aorta with a diameter of at least 50% greater than normal. Documentation of the surgical interventions and autopsy reports was used to confirm the diagnosis. In all patients the investigators collected the history, age of the patients, duration of pain, blood pressure at admission and laboratory parameters (haematocrit, creatinine) and Tenascin C Serum levels after admission to our emergency department immediately. The patients were followed up until hospital discharge and the outcome (survived/died) was recorded.
386 studies on the registry are indexed under Aortic Dissection; 117 are open to participants now.
This study's planned enrollment of 100 is below the median of 183 across 180 observational studies indexed under Aortic Dissection.
Browse Aortic Dissection studies →Central South University is the lead sponsor of 126 studies on the registry; 29 are open to participants now.
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Adult patients who were suspected acute aortic disease in emergency department of the second xiangya hospital.
Exclusion Criteria:
Rupture was defined by direct visualisation of the discontinuity of the aortic wall by computed tomography, sonography, intraoperative findings or at autopsy with detection of blood in the pleural, pericardial or abdominal cavity.
Covert rupture was defined as an intramural haematoma without detection of free blood in the body cavities.
Acute dissection was defined when blood separating the layers of the aortic media was newly diagnosed.
Chronic dissection was defined as the absence of any visible propagation of a known dissection compared to preexisting examinations.
Ectatic aneurysm was defined as a permanent localised dilatation of the aorta with a diameter of at least 50% greater than normal
The level of serum tenascin-C
serum tenascin-C in ng/ml was measured by elasia
Time frame: lesser than 48hours
Characteristics of enrolled subjects
age in years,sex,IBM in kg/m\^2 and associated history was collected
Time frame: lesser than 48hours
The level of D-D，C-reactive protein，elastic protein fragment
The level of D-D in ng/ml，C-reactive proteinin ng/ml，elastic protein fragmentin ng/ml was measured by elasia
Time frame: lesser than 48hours
Plan to share: Yes
No publications or documents are linked to this record.
This study is status unknown, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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Central South University