An interventional study of parathyroidectomy in Hyperparathyroidism, Diabetes and Hypercalcemia, sponsored by Karolinska University Hospital. Withdrawn at 1 site in Sweden. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2020-09-09.
Sponsored by Karolinska University Hospital · Not applicable, Interventional, and Basic science
The aims of this study is to analyse if insulin resistance in primary hyperparathyroidism (pHPT) is normalised after parathyroid adenomectomy and if glucose tolerance test may be useful as a diagnostic tool by predicting potential improvement of insulin sensitivity after biochemical cure of pHPT.
To be conducted at the Karolinska University Hospital, Stockholm. Patients with fb-glucos >6.1 and HbA1c without medical treatment will be included after informed consent and randomised to parathyroidectomy (PTX) within three months or not. The groups will be examined 4 ±4 weeks before and 12±2 weeks after PTX, similar for the control group. The number of participants will be estimated by power calculations based on a pilot study including 20 patients.
The test protocol includes glucose load with control of glucose and insulin, (0, 30, 60 and 120 min) together with measurement of markers of oxidative stress and inflammation.
110 studies on the registry are indexed under Hyperparathyroidism; 12 are open to participants now.
Browse Hyperparathyroidism studies →Karolinska University Hospital is the lead sponsor of 279 studies on the registry; 55 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
HbA1c
A blood test of average blood sugar over the past two to three months, given as a percentage or in mmol/mol. 6.5% (48 mmol/mol) or more is the usual threshold for diabetes, normally confirmed by a second test.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
change in insulin resistance
Procedure: parathyroidectomy
the study participant will be examined parallel with the active comparator
surgical treatment of hyperparathyroidism
Also known as: parathyroid adenomectomy
glucose tolerance test with estimation of insulin resistance
Homa IR
Time frame: 3 months
quality of life - self estimation protocol
EORTC QLQ-C30
Time frame: 3 months
psychological wellbeing
POMS
Time frame: 3 months
anxiety, depression
HAD
Time frame: 6 months
cognition
MoCA-Test
Time frame: 6 months
Plan to share: No
This study is withdrawn, as verified in Sep 2020. You cannot join it, but the record below documents what was studied.
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