An observational study in Hyperparathyroidism, Parathyroid and Mobility, sponsored by University of Florida. Recruiting at 1 site in United States. Open to participants aged 60 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by University of Florida · Observational
This study evaluates whether surgical removal of the parathyroid gland (parathyroidectomy) improves physical function and mobility in older adults with primary hyperparathyroidism (PHPT). PHPT, a common endocrine disorder in older adults, is associated with reduced muscle strength, mobility, and quality of life. This prospective observational study will enroll up to 80 participants aged 60 and older undergoing parathyroidectomy at UF Health. Participants will complete physical performance tests, wear an Actigraph device to assess physical activity, and provide blood samples for biomarker analysis at pre- and post-operative time points. The goal is to characterize changes in physical function and activity following surgery and to identify biomarkers that may predict mobility improvements. Findings will help inform future larger-scale studies and could expand surgical indications for PHPT in older adults.
110 studies on the registry are indexed under Hyperparathyroidism; 12 are open to participants now.
This study's planned enrollment of 80 is below the median of 99 across 37 observational studies indexed under Hyperparathyroidism.
Browse Hyperparathyroidism studies →University of Florida is the lead sponsor of 1,287 studies on the registry; 199 are open to participants now.
Of its 180 completed or terminated interventional studies of FDA-regulated products, 143 (79%) have results posted.
Counted across the registry records on this site, refreshed daily.
This study will enroll adults aged 60 years and older with a confirmed biochemical diagnosis of hypercalcemic primary hyperparathyroidism (PHPT) who are scheduled to undergo parathyroidectomy at UF Health. Eligible participants must be able and willing to provide informed consent and complete all study procedures, including pre- and post-operative physical assessments and blood draws.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Investigational drug or device
A drug or device being studied in a clinical trial.
It may be new, or already approved and being studied for another use, dose or form. Criteria often leave out people who took part in another study of one within a recent period, commonly 30 days or five half-lives.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants who are undergoing a parathyroidectomy at UF health
Distance Walked in Six-Minute Walk Test (6MWT)
Measures walking endurance and aerobic capacity by recording the distance walked in six minutes along a 20-meter course.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Short Physical Performance Battery Score
A composite test assessing balance, gait speed (4-meter walk), and lower body strength (chair stands). Higher scores reflect better function.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Isokinetic Knee Strength (Biodex)
Assesses lower limb muscle strength and endurance using a dynamometer. Reports peak torque and fatigue index.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Grip Strength
Handgrip strength is measured using a dynamometer as a marker of overall muscle strength and frailty risk.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Intensity of Movement using ActiGraph Accelerometry
An objective measure of free-living physical activity using a wearable hip device that captures intensity of movement over 7 days.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Frequency of Movement using ActiGraph Accelerometry
An objective measure of free-living physical activity using a wearable hip device that captures frequency of movement over 7 days.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Duration of Movement using ActiGraph Accelerometry
An objective measure of free-living physical activity using a wearable hip device that captures duration of movement over 7 days.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
CHAMPS Questionnaire Score
A validated self-report tool for older adults that measures weekly frequency and duration of common physical activities.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Pasieka Parathyroidectomy Assessment of Symptoms (PAS)
A validated 13-item questionnaire measuring severity of neurocognitive and neuromuscular symptoms common in PHPT, such as fatigue, irritability, and memory loss.
Time frame: At pre-operative assessment and at 3 month post-operative assessment
Concentration of Plasma Cytokine Biomarkers
Blood-based analysis of myokines (e.g., IL-6, myostatin, LIF, irisin), osteokines (e.g., IGF-1, FGF-21, osteocalcin), and adipokines (e.g., adiponectin, TNF-α) associated with muscle-organ crosstalk, inflammation, and mobility.
Time frame: Blood work will be collected at the pre-operative assessment, the 2 week post-operative assessment, 3 month post-operative assessment and the 6 month post-operative assessment
Plan to share: Undecided
No publications or documents are linked to this record.
Started Aug 2025 (actual). Primary completion is estimated for Mar 2027, 18 months after the start.
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