An observational study in Healthy, sponsored by Erasme University Hospital. Completed at 1 site in Belgium. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-11-23.
Sponsored by Erasme University Hospital · Observational
Various indexes have been proposed to quantify both pulmonary emphysema and airways disease on chest CT scans. It is unknown whether these indexes should be consider in absolute values or as compared to predicted normal values. The purposes of the present study is thus : a) to measure these indexes at CT in healthy volunteers; b) to investigate their relations with gender, height and weight.
87 healthy volunteers performed consecutively a low-dose chest CT scan and pulmonary function tests:
On chest CT scans, indexes reflecting pulmonary emphysema and airways measurements have been computed by using dedicated softwares. Each of our three readers performed two reading sessions.
Relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units; luminal area and wall thickness in third and fourth generations airways were recorded.
CT indexes were compared with gender, height and weight.
187 studies on the registry are indexed under Pulmonary Emphysema; 19 are open to participants now.
This study's enrollment of 87 is above the median of 74 across 48 observational studies indexed under Pulmonary Emphysema.
Browse Pulmonary Emphysema studies →Erasme University Hospital is the lead sponsor of 178 studies on the registry; 34 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Healthy Volunteers
Exclusion Criteria:
Inclusion criteria: 1. Aged 18 or more. 2. Never smoked. 3. No respiratory infection in the 4 weeks before the begin of the study. 4. No history of pulmonary resection. 5. No active malignancy or malignancy of any organ system within the past 5 years.
Radiation: Low-dose chest CT scans
Supine chest CT scan after full inspiration. Acquisition parameters: (Topogram 35 mA 120 kV 512 mm length) 35 quality ref mAs with care-dose ON 120 kV Pitch 1.4 Rotation time 0.33 s Acquired images 64 x 0.6 mm
CT index - RA960 (%)
From acquired data, images were reconstructed using a soft algorithm. On these soft images, the relative area of lung parenchyma with attenuation value less than -960 Hounsfield Units was computed (expressed in %), as an index representative of pulmonary emphysema extent.
Time frame: 4 hours
CT index - LA3rd (mm2)
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in third generations of airways (expressed in mm2).
Time frame: 4 hours
CT index - LA4th (mm2)
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway lumen was measured in fourth generations of airways (expressed in mm2).
Time frame: 4 hours
CT index - WT3rd (mm)
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in third generations of airways (expressed in mm).
Time frame: 4 hours
CT index - WT4th (mm)
From acquired data, images were reconstructed using a high resolution algorithm. On these high-resolution images, the airway wall was measured in fourth generations of airways (expressed in mm).
Time frame: 4 hours
Pulmonary function tests - VC (l)
Vital capacity was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - FVC (l)
Forced vital capacity was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - FRC (l)
Functional residual capacity capacity was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - TLC (l)
Total lung capacity was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - RV (l)
Residual volume was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - FEV1 (l)
Forced expiratory volume in one second was measured (expressed in l).
Time frame: 4 hours
Pulmonary function tests - DLCO (ml/min/ mmHg)
Diffusion lung capacity for carbon monoxide was measured (expressed in ml/min/ mmHg)
Time frame: 4 hours
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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Erasme University Hospital