An observational study in Obstructive Sleep Apnoea, Obesity and Hypoxia, sponsored by Royal Devon and Exeter NHS Foundation Trust. Completed at 2 sites in United Kingdom. Open to male participants aged 18 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-02-17.
Sponsored by Royal Devon and Exeter NHS Foundation Trust · Observational
Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.
Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.
1,422 studies on the registry are indexed under Apnea; 160 are open to participants now.
This study's enrollment of 15 is below the median of 106 across 386 observational studies indexed under Apnea.
Browse Apnea studies →Royal Devon and Exeter NHS Foundation Trust is the lead sponsor of 62 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Subjects with newly diagnosed obstructive sleep apnoea and controls
Exclusion Criteria:
Continuous positive airway pressure devices
Device: Continuous positive airway pressure devices
subjects with no obstructive sleep apnoea
overnight use of CPAP device
Also known as: CPAP
pO2 in adipose tissue by Clarke type electrode
Measurement of pO2 by Clarke type electrode
Time frame: 4 months
blood flow in adipose tissue by laser Doppler techniques
assessment of tissue blood flow by laser Doppler techniques
Time frame: 4 months
adipose tissue gene expression of HIF-1alpha
adipose tissue expression of hypoxia related genes
Time frame: 4 months
This study is completed, as verified in Feb 2017. You cannot join it, but the record below documents what was studied.
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Royal Devon and Exeter NHS Foundation Trust