An observational study in Amyotrophic Lateral Sclerosis, sponsored by Universidad Católica San Antonio de Murcia. Completed at 1 site in Spain. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-07-24.
Sponsored by Universidad Católica San Antonio de Murcia · Observational
Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurological disease. Nonspecific symptoms lead to a delay in the diagnosis, only confirmed by the electrophysiologic study.
Objectives.
Methods. A longitudinal observational study in a consecutive sample of patients diagnosed with ALS will be realized. All the patients will be examined 3 times during 6 months and capabilities associated with ALS and muscle strength will be assessed. Bilateral and cross sectional ultrasonography of several muscles and also median and tibial nerves will be performed. All the images will be processed and analyzed for obtaining morphometric variables (muscle thickness and nerve area) and textural ones (echogenic variation, entropy, homogeneity, textural contrast and correlation). Frequency of twitches will be also recorded. After longitudinal study, a survival study will be performed in relation to functional and sonographic variables.
717 studies on the registry are indexed under Motor Neuron Disease; 137 are open to participants now.
This study's enrollment of 60 is below the median of 109 across 217 observational studies indexed under Motor Neuron Disease.
Browse Motor Neuron Disease studies →Universidad Católica San Antonio de Murcia is the lead sponsor of 132 studies on the registry; 18 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patient with Amyotrophic Lateral Sclerosis.
Exclusion Criteria:
Measuring muscle thickness.
This measurement is carried out in the biceps brachialis, forearm flexors, quadriceps and tibialis anterior, which will be compared between patient with ALS and control group.
Time frame: 6 months
Measurement muscle strength.
Graded on the medical research council scale
Time frame: 6 months
Measurement ALS Functional Rating Scale (ALSFRS-r) scale.
Recorded as the global score
Time frame: 6 months
Measurement muscle fasciculations.
Each muscle will be screened during 10 s.
Time frame: 6 months
Measuring muscle echointensity.
It will be measured using the Image J (v.1.48) software in the biceps brachialis, forearm flexors, quadriceps and tibialis anterior, which will be compared between patient with ALS and control group.
Time frame: 6 months
Measuring nerve area.
This measurement is carried out in the median and tibialis posterior nerves, which will be compared between patient with ALS and control group.
Time frame: 6 months
This study is completed, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Universidad Católica San Antonio de Murcia