An observational study in Schizophrenia, Major Depressive Disorder and Bipolar Depressive Disorder, sponsored by Pontifical Catholic University of Argentina. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-10-20.
Sponsored by Pontifical Catholic University of Argentina · Observational
Antipsychotic drugs are characterized by blocking dopaminergic D2 receptors. They have been found to be effective and safe for the treatment of schizophrenia, bipolar disorders, depressive episodes associated with bipolar disorder, or psychotic symptoms in the context of Parkinson's disease. Atypical antipsychotics have lower blocking potency on D2 receptors, at the time that interact with serotoninergic, adrenergic and histaminergic receptors, among others. Quetiapine extended-release has the same clinical efficacy as the immediate-release formulation, but reduces the amount of daily doses, possibly contributing to increased treatment adherence.
The purpose of this registry is to explore adherence to treatment, the occurrence of adverse drug reactions and the clinical outcomes in a sample of patients under treatment with atypical antipsychotics in several Central American countries. For this study, clinical data will be extracted from the medical records of 1000 patients with schizophrenia, depressive disorders or Parkinson's Disease with hallucinations. Occurrence of adverse drug reactions, namely weight gain, somnolence, extrapyramidal reactions and symptoms of orthostatic hypotension; adherence to treatment; and changes in quality of life and clinical status will be assessed during the first 8 weeks of treatment.
patients under atypical antipsychotic therapy
Exclusion Criteria:
Drug: Atypical Antipsychotics
any atypical antipsychotic
Occurrence of Adverse Drug Reactions
Time frame: 8 weeks
Adherence to treatment
Time frame: 8 weeks
Quality of Life
Time frame: 8 weeks
Clinical status (CGI score)
Time frame: 8 weeks
No study locations are listed for this record.
This study is completed, as verified in Oct 2015. You cannot join it, but the record below documents what was studied.
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Pontifical Catholic University of Argentina