An interventional study of Handgrip and Altitude simulation in Microvascular Coronary Dysfunction, sponsored by Cedars-Sinai Medical Center. Recruiting at 1 site in United States. Open to female participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-09-01.
Sponsored by Cedars-Sinai Medical Center · Not applicable, Interventional, and Diagnostic
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain, primarily impacts women. There are an estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent data from our research group suggests that coronary microvascular disease impairs the way the heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to better understand the pathophysiology of the disease. The investigators will recruit 30 volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and 10 age-match women for the group with microvascular disease). Subjects will undergo a series of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's planned enrollment of 30 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Cedars-Sinai Medical Center is the lead sponsor of 441 studies on the registry; 108 are open to participants now.
Of its 62 completed or terminated interventional studies of FDA-regulated products, 47 (76%) have results posted.
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Exclusion Criteria:
10 women with microvascular disease
Other: Handgrip · Other: Altitude simulation · Other: Leg exercise
10 age-matched women with no evidence of microvascular disease
Other: Handgrip · Other: Altitude simulation · Other: Leg exercise
10 healthy individuals who will help to synchronize our imaging and stress testing maneuvers.
Other: Handgrip · Other: Altitude simulation · Other: Leg exercise
Subjects will be asked to squeeze and handgrip dynamometer to increase cardiac metabolic demand
Subjects will breathe a lower concentration of oxygen to simulate the effects of altitude.
Subjects will perform leg exercise to increase metabolic demand.
Diastolic function by MRI
Time frame: 24 hours
Plan to share: Yes
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Cedars-Sinai Medical Center