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WithdrawnNCT02188602Updated Aug 22, 2022

Effect of Cumulative Chloride Dose on Development of Acute Kidney Injury in Critically Ill Children

An observational study in Acute Kidney Injury, sponsored by Stanford University. Withdrawn at 1 site in United States. Open to participants aged 1 Month to 18 Years. Per ClinicalTrials.gov, last updated 2022-08-22.

Sponsored by Stanford University · Observational

Why this study was withdrawn
Researcher left institution
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
0
Ages
1 Month to 18 Years
Sex
All
01

Study summary

The investigators would like to investigate the effect of chloride dosing on the development of acute kidney injury in critically ill patients. The investigators hypothesis is that administering intravenous fluids with higher chloride content are more likely to lead to acute kidney injury.

Read the detailed description

Retrospective chart review from 2008-2012 evaluating chloride dosing and serum chloride levels and their effects on acute kidney injury in the pediatric ICU. Patients will be included for the first seven days of their PICU stay.

02

Conditions studied

  • Acute Kidney Injury

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03

In context

Acute Kidney Injury

1,641 studies on the registry are indexed under Acute Kidney Injury; 380 are open to participants now.

Browse Acute Kidney Injury studies →

Lead sponsor

Stanford University is the lead sponsor of 2,162 studies on the registry; 429 are open to participants now.

Of its 267 completed or terminated interventional studies of FDA-regulated products, 207 (78%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
1 Month to 18 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Children \< 18 yo admitted to the Pediatric Intensive Care Unit at Lucile Packard Children's Hospital with admitting diagnosis of sepsis, respiratory failure, or liver failure

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age less than 18 years
  • PICU admitting diagnosis of sepsis, respiratory failure, or hepatic failure.

Exclusion criteria

Exclusion Criteria:

  • hyponatremia or hypernatremia at PICU admission
  • preexisting diagnosis of End-stage renal disease or renal transplant
  • presence of neurologic comorbidities.
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
0 participants (actual)
Patient registry
No

Groups and cohorts

  • High Chloride Dose

    Patients receiving high dosing of chloride

  • Low Chloride Dose

    Patients receiving low dosing of chloride

06

What researchers measure

Primary outcomes

  1. Acute Kidney Injury

    or sooner if death or discharged

    Time frame: 7 days

Secondary outcomes

  1. PICU length of stay

    Time frame: 7 days

  2. Hospital length of stay

    Time frame: 7 days

  3. Number of ventilator days

    Time frame: 7 days

  4. Mortality

    Time frame: 7 days

07

Study locations

1 site
  • Lucile Packard Children's Hospital
    Palo Alto, California 94303, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 22, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT02188602
Responsible party
Sponsor
First posted
Jul 11, 2014
Start date
Jul 2013
Primary completion
Jun 2015 (estimated)
Completion
Jun 2015 (estimated)
Last update
Aug 22, 2022

Study contacts

Weiwen V Shih, MD
principal investigator · Stanford University

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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