ClinicalTrials.gg
RecruitingNCT05619185Updated Oct 19, 2026

A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners

An interventional study of CRAFT Web-Based Intervention and Phone-Based CRAFT in Alcohol Abuse, Alcohol Use Disorder and Alcohol Drinking, sponsored by Stanford University. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-19.

Sponsored by Stanford University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Jun 2024; still recruiting 2 years 4 months later.
Updated Oct 19, 2026Primary outcomes revisedGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
744
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to evaluate the efficacy of an adaptive web intervention (Partners Connect) on military spouse drinking behaviors (CPs) and service member help-seeking (SMs). The investigators want to identify for whom this intervention is most efficacious and on what drinking behaviors and mechanisms. The investigators hypothesize that the intervention will reduce concerned partner drinking and increase service member help-seeking, compared to website resources, and that phone-based CRAFT will increase help-seeking behaviors, compared to those who are guided via a CRAFT workbook.

Our outcome is to evaluate the efficacy of an adaptive CP intervention on CP well-being and service member help-seeking.

02

Conditions studied

  • Alcohol Abuse
  • Alcohol Use Disorder
  • Alcohol Drinking
  • Relations, Interpersonal
  • Military Family

Keywords

  • military
  • alcohol
  • drinking
  • substance use
03

In context

Alcoholism

1,674 studies on the registry are indexed under Alcoholism; 331 are open to participants now.

This study's planned enrollment of 744 is above the median of 88 across 1,428 interventional studies indexed under Alcoholism.

Browse Alcoholism studies →

Lead sponsor

Stanford University is the lead sponsor of 2,168 studies on the registry; 431 are open to participants now.

Of its 267 completed or terminated interventional studies of FDA-regulated products, 207 (78%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • at least 18 years of age;
  • be living together with their partner, with no plans to change that status in the next 2 months;
  • not be in the military themselves (to reduce concerns about mandated reporting of alcohol use);
  • score ≥4 on the AUDIT-C for females or ≥5 for males/other;
  • respond yes to "Do you feel safe in your current relationship?" from the Partner Violence Screen;
  • report not currently being in mental health or alcohol treatment (CP and SM)
  • understand English fluently,
  • be willing to try an online program to address risky drinking.

We require cohabitating CPs and SMs with no anticipated changes in the next two months to ensure close contact and opportunity to practice new skills, and those who would feel safe participating.

Exclusion criteria

Exclusion Criteria:

  • CPs in substance use treatment or their SM was in treatment in the last three months;
  • does not feel safe in the current relationship;
  • does not understand English fluently;
  • has an impaired capacity (cognitive, visual, or hearing);
  • is not cohabitating with their SM
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
744 participants (estimated)

Study arms

  • Experimental
    Intervention

    Those randomized to the CRAFT intervention will receive a web-based intervention

    Behavioral: CRAFT Web-Based Intervention · Behavioral: Phone-Based CRAFT · Behavioral: CRAFT Workbook

  • Active comparator
    Control

    Those randomized to CONTROL will complete a self-guided intervention

    Behavioral: Gottman Self-Guided Resources

  • Experimental
    Phone Based CRAFT

    If a member of the recruited dyad does not respond, then participants will be randomized to receive phone-based CRAFT

    Behavioral: CRAFT Web-Based Intervention · Behavioral: Phone-Based CRAFT

  • Active comparator
    CRAFT Workbook

    If a member of the recruited dyad does not respond, then participants will be randomized to receive a CRAFT workbook

    Behavioral: CRAFT Web-Based Intervention · Behavioral: CRAFT Workbook

Interventions

  • BehavioralCRAFT Web-Based Intervention

    Session 1 addresses CPs' mental health issues and drinking. CPs select reasons why they are seeking help and steps they will take towards those goals. Session 2 is focused on improving their relationship through communication exercises. Session 3 is focused on functional analysis of their partner's drinking, and how to positively reinforce their partner's sobriety and negatively reinforce their drinking. Finally, Session 4 focuses on continuing self-care and talking with their partner about their concerns while interacting with them in healthy ways. The WBI contains audio, video, text, and exercises that utilize digital storytelling and vignettes to convey teaching points - a method utilized by the military to address stigma and increase treatment utilization. Actresses portrayed different experiences that the CP may be going through and modeled skills. CPs clicked on the vignette that they most connected with and followed that character across all the sessions.

    Also known as: WBI, Partners Connect, Web-based intervention (WBI)

  • BehavioralPhone-Based CRAFT

    The phone-based CRAFT intervention consists of six individual sessions with a CRAFT clinician that will explore what they learned from the WBI and additional skills they need. Session content includes positive reinforcement of non-drinking SM behaviors, refraining from interfering in SM's consequences of alcohol use, communication skills, and self-care.

    Also known as: Community Reinforcement and Family Training (CRAFT) phone sessions

  • BehavioralCRAFT Workbook

    The self-directed CRAFT workbook Table 1.Partners Connect WBI has a parent and partner version that uses CRAFT to help the CP help with understanding, self-care, communication, and actions (e.g., how to react when a partner has been using substances and when they have not been using substances, how to talk to partner so that they are more likely to be heard) and includes more information about communicating than the WBI and several interactive worksheets.

    Also known as: Community Reinforcement and Family Training (CRAFT) workbook

  • BehavioralGottman Self-Guided Resources

    To match time spent reviewing the website, CPs will receive an orientation guide that includes the website URL and a 4-week guide for how they can navigate this website for 20-30 minutes per week (e.g., read article "'It's Not My Fault!': Why Defensiveness is Damaging" and write down one tool to dissolve defensiveness you're willing to try). We will send reminder emails each week to visit the website and include questions in the emails and our first online follow-up survey asking CPs approximately how many times they visited the website and how long they spent viewing content on the website. Reminder emails will be programmed such that CPs get directed automatically to the website if the CP notes no time spent on it.

06

What researchers measure

Primary outcomes

  1. CP Depression

    Depression as measured by the global score on the Patient Health Questionnaire 9-item (PHQ-9). Scores range from 0 - 27. Higher scores indicate more severe depression.

    Time frame: Baseline to 6 month follow-up

  2. CP Anxiety

    Anxiety as measured by the global score on the Generalized Anxiety Disorder 7-item scale (GAD-7). Scores range from 0 - 21. Higher scores indicate more severe anxiety.

    Time frame: Baseline to 6 month follow-up

  3. Service Member help-seeking

    Completion of the personalized normalized feedback (PNF) component of the intervention as a signal of increase help-seeking behavior

    Time frame: Baseline to 6 month

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Osilla KC, Gore KL, Pedersen ER, Hummer JF, DeYoreo M, Manuel JK, McKay JR, Kim JP, Nameth K. Study protocol for a sequential multiple assignment randomized trial to reduce risky drinking among service members and their partners. Contemp Clin Trials. 2023 Oct;133:107324. doi: 10.1016/j.cct.2023.107324. Epub 2023 Aug 29. PubMed 37652360 ↗

Individual participant data

Plan to share: No — There will be no IPD shared

09

Updates

1 registry update since Sep 25, 2026
Primary outcomes
2 description edited
What changed in the outcomes
  • DescriptionCP Anxiety: how it is measured was reworded
  • DescriptionCP Depression: how it is measured was reworded
Oct 19, 2026
Show all 1 update
  1. Oct 19, 2026
    Primary outcomes 2 description edited
    What changed in the outcomes
    • DescriptionCP Anxiety: how it is measured was reworded
    • DescriptionCP Depression: how it is measured was reworded
    + 1 other change: verification date

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT05619185
Collaborators
University of Southern California, RAND, Northern California Institute of Research and Education, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Responsible party
Karen Osilla (Associate Professor, Stanford University) — Principal investigator
First posted
Nov 16, 2022
Start date
Jun 14, 2024
Primary completion
Aug 31, 2027 (estimated)
Completion
Aug 31, 2027 (estimated)
Last update
Oct 19, 2026

Study contacts

Kat Nameth, BS
Contact
knameth@stanford.edu
6505429699

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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