An interventional study of Nitrate rich beverage and Nitrate free beverage in Chronic Obstructive Pulmonary Disease, sponsored by Royal College of Surgeons, Ireland. Completed. Per ClinicalTrials.gov, last updated 2014-06-05.
Sponsored by Royal College of Surgeons, Ireland · Not applicable, Interventional, and Supportive care
The acute consumption of dietary nitrate has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption, in the form of beetroot juice, might increase incremental shuttle walk test (ISWT) distance in COPD subjects.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with peripheral vascular disease. Many COPD patients have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in COPD subjects compared to a matched, low-nitrate drink.
This study is a randomized, double-blind placebo-controlled, crossover trial.
Resting blood pressure, phlebotomy and ISWT are performed. Following completion, each subject is randomized to consume beetroot juice or placebo. 3 hours later, the same assessments are repeated by the same people. After a 7d washout, the entire protocol is repeated with the crossover beverage.
2,592 studies on the registry are indexed under Lung Diseases, Obstructive; 198 are open to participants now.
This study's enrollment of 12 is below the median of 66 across 1,837 interventional studies indexed under Lung Diseases, Obstructive.
Browse Lung Diseases, Obstructive studies →Royal College of Surgeons, Ireland is the lead sponsor of 93 studies on the registry; 44 are open to participants now.
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Exclusion Criteria:
Nitrate rich beverage will contain 140ml nitrate rich beetroot juice + 200ml blackcurrant juice containing 12.7mmol nitrate
Dietary Supplement: Nitrate rich beverage
Nitrate free beverage will 140ml water + 200ml blackcurrant juice containing \<0.5mmol nitrate
Dietary Supplement: Nitrate free beverage
Following randomisation on day 1, subjects will consume either the nitrate or nitrate-free beverage and then the crossover beverage on day 8.
Also known as: Nitrate rich beetroot juice
Following randomisation on day 1, subjects will consume either the nitrate or nitrate-free beverage and then the crossover beverage on day 8.
Also known as: Placebo beverage
Change in Incremental Shuttle Walk Test Distance
The change between day 1, time 0 and day 1, time 3h will be compared to the changes between day 8, time 0 and day 8, time 3h.
Time frame: day 1, time 0, day 1, time 3h, day 8, time 0, day 8, time 3h
Resting blood pressure
The change between day 1, time 0 and day 1, time 3h will be compared to the changes between day 8, time 0 and day 8, time 3h.
Time frame: day 1, time 0, day 1, time 3h, day 8, time 0, day 8, time 3h
No study locations are listed for this record.
This study is completed, as verified in Jun 2014. You cannot join it, but the record below documents what was studied.
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Royal College of Surgeons, Ireland