An interventional study of antibiotic treatment in Erythema Migrans, sponsored by University Medical Centre Ljubljana. Status unknown at 1 site in Slovenia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-04-22.
Sponsored by University Medical Centre Ljubljana · Not applicable, Interventional, and Basic science
The main objective of this study is to characterize the inflammatory proteins, gene polymorphisms, and transcriptome profiles in patients with erythema migrans to gain better insight into pathogenesis of early Lyme borreliosis and to define new immune modulators that could serve as biomarkers of disease activity.
25 studies on the registry are indexed under Glossitis, Benign Migratory; 4 are open to participants now.
This study's planned enrollment of 150 is below the median of 200 across 13 interventional studies indexed under Glossitis, Benign Migratory.
Browse Glossitis, Benign Migratory studies →University Medical Centre Ljubljana is the lead sponsor of 296 studies on the registry; 72 are open to participants now.
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Exclusion Criteria:
adult patients with erythema migrans will be treated with oral antibiotics
Drug: antibiotic treatment
Patient will be treated with: doxycycline orally, 100 mg, bid, 14 days or cefuroxime axetil orally, 500 mg, bid, 14 days or amoxicillin orally, 500 mg, tid, 14 days
inflammatory proteins in erythema migrans patients
The inflammatory immune profiles will be assessed using Luminex to measure the expression of cytokines and chemokines representative of innate and adaptive TH1, TH2, TH17, and B cell responses in serum and if available, skin, of patients during active infection and after treatment.
Time frame: up to 12 months follow-up
gene polymorphisms in erythema migrans patients
The expression of disease-relevant genomic variants will be assessed using ImmunoChip.
Time frame: at enrollment
transcriptome profiles in erythema migrans patients
We will use RNA sequencing of individual immune cell subtypes from patients to determine their transcriptome.
Time frame: at 6 month follow-up
This study is status unknown, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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