A Phase 3 interventional study of EM-amoxicillin 3 x 10 days and EM-amoxicillin 3 x 14 days in Erythema Migrans, sponsored by University Medical Centre Ljubljana. Recruiting at 2 sites in Slovenia. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-25.
Sponsored by University Medical Centre Ljubljana · Phase 3, Interventional, and Treatment
The purpose of this study is to compare the efficacy of different amoxicilline treatment regimens in patients with erythema migrans.
25 studies on the registry are indexed under Glossitis, Benign Migratory; 4 are open to participants now.
This study's planned enrollment of 200 is close to the median of 200 across 13 interventional studies indexed under Glossitis, Benign Migratory.
Browse Glossitis, Benign Migratory studies →University Medical Centre Ljubljana is the lead sponsor of 296 studies on the registry; 72 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
amoxicillin for 10 days
Drug: EM-amoxicillin 3 x 10 days
amoxicillin for 14 days
Drug: EM-amoxicillin 3 x 14 days
controls without Lyme borreliosis
Other: Controls
Patients will receive amoxicillin 500 milligram tid for 10 days
Also known as: 10 days
Patients will receive amoxicillin 500 milligram tid for 14 days
Also known as: 14 days
No intervention.
Number (frequency) of patients with objective manifestations of Lyme borreliosis or subjective Lyme borreliosis-associated/post-Lyme borreliosis symptoms
At each visit physical examination wil be performed and clinical signs indicating objective manifestations of Lyme borreliosis, such as erythema migrans, will be searched for and documented. At each visit patients will be asked an open question about any health-related symptoms that had newly developed or worsened since the onset of erythema migrans. If these symptoms will have no other known medical explanation, they will be regarded as Lyme borreliosis-associated constitutional symptoms at enrolment or post-Lyme borreliosis symptoms at follow-up.
Time frame: One year follow-up
Number (frequency) of patients with nonspecific symptoms
At each visit patients will be asked to complete a written questionnaire asking whether they had had any of eight non-specific symptoms (fatigue, arthralgias, headache,myalgias, paraesthesias, memory difficulties, concentration difficulties and irritability) within the preceding week.
Time frame: One year follow-up
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Medical Centre Ljubljana →