ClinicalTrials.gg
CompletedNCT06988865Updated May 25, 2025

Benign Migratory Glossitis Associated With Antiangiogenic Drugs

An observational study in Cancer and Geographic Tongue, sponsored by Instituto do Cancer do Estado de São Paulo. Completed at 1 site in Brazil. Per ClinicalTrials.gov, last updated 2025-05-25.

Sponsored by Instituto do Cancer do Estado de São Paulo · Observational

Study type
Observational
Model
Case-only
Time perspective
Retrospective
Enrollment
8
Sex
All
01

Study summary

Oral clinical descriptions related to adverse events in patients treated with those elective multi-targeted receptor tyrosine kinase inhibitors and a recombinant humanised monoclonal antibody

Read the detailed description

Electronical medical and dental records, high-resolution digital photograph were reviewed. Demographic data, medical background, clinical and laboratory information were recorded for each individual case.

02

Conditions studied

  • Cancer
  • Geographic Tongue

Keywords

  • antiangiogenic drugs
  • glossitis benign migratory
03

In context

Neoplasms

10,818 studies on the registry are indexed under Neoplasms; 2,324 are open to participants now.

This study's enrollment of 8 is below the median of 200 across 2,638 observational studies indexed under Neoplasms.

Browse Neoplasms studies →

Lead sponsor

Instituto do Cancer do Estado de São Paulo is the lead sponsor of 91 studies on the registry; 22 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Hospital -Instituto do Cancer do Estado de Sao Paulo-ICESP

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • patient's charts which underwent antiangiogenic targeted drugs

Exclusion criteria

Exclusion Criteria:

  • chemoterapy without angiogenesis inhibitors
05

Study design

Observational model
Case-only
Time perspective
Retrospective
Enrollment
8 participants (actual)
Patient registry
No

Groups and cohorts

  • angiogenesis inhibitors

    Oral clinical manifestation

    Other: Clinical evaluation

Interventions

  • OtherClinical evaluation

    treatment methods, associated symptoms, evolution and clinical presentation

    Also known as: clinical images

06

What researchers measure

Primary outcomes

  1. Benign migratory glossitis

    erythematous erosions, with loss of filiform papillae, surrounded by white circinate rims on the dorsal tongue

    Time frame: From enrollment to the end of study at 7 years

Secondary outcomes

  1. Adverse events

    Dysgeusia , dermatologic toxicities such as skin erythemas and vesicles on the palms of the hands and burning sensation

    Time frame: From enrollment to the end of study at 7 years

07

Study locations

1 site
  • Instituto do Cancer do Estado de São Paulo
    Sao Paulo, SP 01246-000, Brazil
08

References and documents

Individual participant data

Plan to share: Undecided — undecided

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jul 2017 to primary completion in Jan 2020, 29 months.

How these figures are worked out, and which studies are left out of them.

Registered
May 1, 2025
First posted
May 25, 2025
StartActual
Jul 16, 2017
Primary completionActual
Jan 10, 2020
CompletionActual
Feb 1, 2024
Last update
May 25, 2025
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 25, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06988865
Lead sponsor
Instituto do Cancer do Estado de São Paulo
Responsible party
MAURICIO NEVES GOMES (Assistant, Dental Oncology Service, Instituto do Câncer do Estado de São Paulo (ICESP-FMUSP), Instituto do Cancer do Estado de São Paulo) — Principal investigator
First posted
May 25, 2025
Start date
Jul 16, 2017
Primary completion
Jan 10, 2020
Completion
Feb 1, 2024
Last update
May 25, 2025

Study contacts

Mauricio Neves Gomes, PhD
principal investigator · Instituto do Cancer do Estado de São Paulo
Wagner Gomes da Silva, PhD
principal investigator · Instituto do Cancer do Estado de São Paulo

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.

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