A Phase 2 interventional study of 70% glycolic acid in Acne Scars, sponsored by National University Hospital, Singapore. Status unknown at 1 site in Singapore. Open to participants aged 21 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-04-30.
Sponsored by National University Hospital, Singapore · Phase 2, Interventional, and Treatment
Our study involves the evaluation of a high potency chemical peel in its efficacy and safety profile for the treatment of acne scars. This chemical peel regime is a high potency peel of 70% glycolic acid combined with vitamin C that is purported to provide a good balance between yielding results and patient safety. We aim to evaluate its efficacy and safety profile of a single application. The study design is based on a single group that compares pre- vs post-intervention. 10 patients with atrophic acne scars of skin type I-IV will be recruited. Potential benefits include improvement of post acne scars with a short downtime and risks include post peel hyper pigmentation and scarring. We believe that this treatment will be highly beneficial to patients with post acne scarring.
This chemical peel regime has good efficacy and safety profile for the treatment of acne scars.
Primary endpoints:
Secondary endpoints:
Postacne hyperpigmentation index (PAHPI)
-Each of these 3 variables --size, intensity, and number of lesions is weighted and the summation of the weighted variables gives the total PAHPI score, ranging 6 to 22.
730 studies on the registry are indexed under Acne Vulgaris; 86 are open to participants now.
This study's planned enrollment of 10 is below the median of 69 across 628 interventional studies indexed under Acne Vulgaris.
Browse Acne Vulgaris studies →National University Hospital, Singapore is the lead sponsor of 444 studies on the registry; 96 are open to participants now.
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Exclusion Criteria:
Single arm study - pre and post peel assessment
Drug: 70% glycolic acid
Efficacy Assessment
1. ECCA (échelle d'évaluation clinique des cicatrices d'acné) grading scale for quantitative grading of acne scars * V-shaped atrophic scars with diameter \<2 mm: 15 * U-shaped atrophic scars with a diameter of 2-4 mm: 20 * M-shaped atrophic scars with diameter \>4 mm: 25 * Superficial elastolysis: 30 * Hypertrophic scars with a \<2-year duration: 40 * Hypertrophic scars of \>2-year duration: 50 A semi-quantitative scoring of number of each scar will be performed * No scars: 0 * Less than five scars: 1 * Between five and 20 scars: 2 * More than 20 scars: 3 2. Patient Assessment Based on 1 to 10 point scale; 1- nil acne scars and 10- severe acne scar Secondary endpoints 1) Postacne hyperpigmentation index (PAHPI)
Time frame: 3 months
Safety Assessment
) Safety Assessment (This is also an ordinal scale) i. Score of redness ii. Score of swelling iii. Score of oozing/crusting iv. Post peel hyperpigmentation v. Post peel scarring
Time frame: 3 months
This study is status unknown, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.
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National University Hospital, Singapore