An interventional study of Care and Not care in Chronic Kidney Disease, sponsored by University Hospital, Bordeaux. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by University Hospital, Bordeaux · Not applicable, Interventional, and Prevention
A large panel of oral and dental diseases exist in patients suffering from chronic kidney disease (CKD) in end-stage renal disease: it concerns teeth, peridontium, alveolar bone and saliva and it has been already described in the literature. The consequences of oral diseases in systemic health are substantial, including increase of inflammatory parameters, alteration of nutrition and increase of cardiovascular risk factors. It has been shown before that several oral diseases can be considered as cardiovascular risk factor in the general population and in diabetic patients through the chronic inflammatory pathway. In CKD patients, the influence of oral diseases on the progression of the chronic kidney disease is not yet established, as most of the studies are focused on stage 5 CKD or dialysis patients. That's why the interactions between dental health and CKD will be evaluated in this population of patients, at different stages of the disease (stages 2 to 5).
The main objective will be to describe the oral diseases at each stage of CKD. Secondary objectives will be: (1) To evaluate the link between the oral health and the chronic kidney disease stage, the nutritional and inflammatory status; (2) Among patients needing dental treatments, to evaluate after 6 months and 12 months whether dental cares have an influence on nutrition parameters, inflammatory status and CKD; (3) to evaluate the completion of dental treatments after the dental consultation including advises on dental health.
The consequences of oral and dental diseases in general health are substantial, including acute infectious process starting from teeth or peridontium, benign or malignant diseases starting from mucosa or teeth/peridontium and an overall reduction of nutrition indices and a decrease of quality of life markers. More recently, an augmentation of systemic inflammatory reaction markers has been shown correlated with periodontal diseases, leading to an increase of cardiovascular diseases and/or diabetic risk in those patients. A large panel of oral and dental diseases has been described in patients suffering from chronic kidney disease (CKD) in a terminal stage or dialysis (haemodialysis and peritoneal dialysis). In CKD patients, the influence of oral diseases on the progression of the chronic kidney disease is not established today, as most of the studies are focused on stage 5 CKD or dialysis patients. That's why the interactions between dental health and CKD will be evaluated in these patients, at different stages of the disease (stages 2 to 5). In this study, it is hypothesized that the augmentation of inflammation and the alteration of nutrition due to oral diseases have an impact on the alteration of CKD patients, through the chronic inflammatory pathway. We will evaluate the oral and dental health at Day 0, 6 months and 12 months using several indices: the oral hygiene-simplified index, the community periodontal index in treatment needs index, the decayed missing filled per tooth index, the number of functional teeth index, the oral health impact profile index, the saliva composition, the evaluation of halitosis and a mucosa evaluation. In parallel, an evaluation of the influence of chronic oral diseases on nutrition, inflammation and progression of chronic kidney disease will be done: biological check-up, nutrition intake statement and body mass index.
3,090 studies on the registry are indexed under Renal Insufficiency, Chronic; 698 are open to participants now.
This study's enrollment of 88 is above the median of 73 across 2,157 interventional studies indexed under Renal Insufficiency, Chronic.
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Exclusion Criteria:
Patient with dental care
Other: Care
Patient with not dental care
Other: Not care
Evolution of the status of oral health, which will be evaluated through several dental epidemiological indices (composite measure)
The primary outcome is a composite measure including : * Oral Hygiene Index-Simplified index (OHI-S) * Community Periodontal Index in Treatment Needs index (CPITN) * Decayed Missing Filled per Tooth Index (DMF-T) * Number of Functional Teeth index (FS-T) * Oral Health Impact Profile index (OHIP) * Saliva Check (stimulated and non stimulated saliva flow, pH, buffer activity) * Halitosis evaluation (quantification of sulfur volatils compounds) * Mucosa evaluation
Time frame: 12 months after the inclusion
Evolution of nutrition statement
food survey, biological assessment and body composition by bioelectrical impedance analysis
Time frame: 12 months after the inclusion
Evolution of chronic inflammation
Time frame: 12 months after the inclusion
Progression of chronic kidney disease (CKD)
Time frame: 12 months after the inclusion
Compliance with dental treatments in CKD patients
Time frame: 12 months after the inclusion
Evolution of CKD diseases with/without dental treatments in those patients who need dental treatments
Time frame: 12 months after the inclusion
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Renal Insufficiency, Chronic →
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