CClinicalTrials.gg
CompletedNCT02025257Updated Apr 15, 2022

Effects of Exercise in Patients With Coronary Artery Disease Aged 80 Years or Older

An interventional study of Exercise in Coronary Artery Disease, sponsored by Sahlgrenska University Hospital. Completed at 1 site in Sweden. Open to participants aged 80 Years and older. Per ClinicalTrials.gov, last updated 2022-04-15.

Sponsored by Sahlgrenska University Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
80 Years and older
Sex
All
01

Study summary

The purpose of this study is to investigate the effects of exercise for patients with coronary artery disease (CAD) aged 80 years and older, with special reference to maximum aerobic capacity, muscle endurance, physical functioning, level of physical activity, health related quality of life, anxiety, depression and endothelial function, compared to a control group.

02

Conditions studied

  • Coronary Artery Disease

Keywords

  • coronary artery disease
  • elderly
  • exercise
  • exercise-based cardiac rehabilitation
03

In context

Coronary Artery Disease

5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.

This study's enrollment of 34 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Sahlgrenska University Hospital is the lead sponsor of 259 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
80 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Clinical diagnosis of acute coronary artery disease
  • Aged 80 years or older

Exclusion criteria

Exclusion Criteria:

  • Inability to understand or speak the Swedish language
  • Serious physical or psychological disease interfering with participation in an exercise intervention
  • Patients are already exercising three times or more/week
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
34 participants (actual)

Study arms

  • Experimental
    Exercise

    Individually prescribed hospital based exercise in group two times a week, home-based exercise once a week. The exercise intervention consists of interval based aerobic exercise on a bicycle ergometer 30 minutes with intensity level at 13-17 at Borg scale, resistance exercises and balance exercises

    Other: Exercise

  • No intervention
    Control

    Patients are asked to live as usual.

Interventions

  • OtherExercise

    Individually prescribed hospital based exercise in group two times a week, home-based exercise once a week. The exercise intervention consists of interval based aerobic exercise on a bicycle ergometer 30 minutes with intensity level at 13-17 at Borg scale, resistance exercises and balance exercises

06

What researchers measure

Primary outcomes

  1. Change in maximum aerobic capacity

    A maximum exercise test on an electronically braked cycle ergometer, with watts as marker of maximum aerobic capacity.

    Time frame: At baseline and after 4 months

Secondary outcomes

  1. Change in level of physical activity

    Level of physical activity will be measured by an accelerometer and an activity diary

    Time frame: At baseline and after 4 months

  2. Change in muscular endurance

    Will be measured by three clinical endurance tests including unilateral isotonic heel lift, unilateral isotonic shoulder flexion, bilateral isometric shoulder abduction

    Time frame: At baseline and after 4 months

  3. Change in physical functioning

    Including tests of balance: short physical performance battery, one leg standing, timed up and go, and the activities specific balance confidence scale.

    Time frame: At baseline and after 4 months

  4. Change in health related quality of life

    measured by a self-rated health questionnaire

    Time frame: At baselline and after 4 months

  5. Change in anxiety and depression

    measured by the hospital anxiety and depression scale

    Time frame: At baseline and after 4 months

  6. Change in endothelial function

    Evaluated with non-invasive ultrasound

    Time frame: At baseline and after 4 months

  7. Change in transthoracic evaluation of resting coronary flow velocity

    Time frame: At baseline and after 4 months

07

Study locations

1 site
  • Department of physiotherapy, Sahlgrenska University Hospital
    Gothenburg, Select A State… 41345, Sweden
08

References and documents

Publications

  • Brosved M, Hirlekar G, Philip Wigh J, Sundberg H, Ziden L, Karlsson T, Albertsson P, Back M. Effects of Cardiac Rehabilitation on Physical Fitness, Physical Function, and Self-reported Outcomes in Patients >/=80 yr: A RANDOMIZED CONTROLLED TRIAL. J Cardiopulm Rehabil Prev. 2022 Sep 1;42(5):331-337. doi: 10.1097/HCR.0000000000000683. Epub 2022 Mar 31. PubMed 35362694 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 15, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02025257
Lead sponsor
Sahlgrenska University Hospital
Responsible party
Maria Bäck (Phd, RPT, Sahlgrenska University Hospital) — Principal investigator
First posted
Jan 1, 2014
Start date
Dec 2013
Primary completion
May 2019
Completion
Apr 2022
Last update
Apr 15, 2022

Study contacts

Maria Bäck, PhD
principal investigator · Department of Physiotherapy, Sahlgrenska University Hospital, Gothenburg, Sweden
Per Albertsson, PhD
study chair · Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion