An observational study in Pelvic Organ Prolapse, sponsored by Turku University Hospital. Completed at 1 site in Finland. Open to female participants. Per ClinicalTrials.gov, last updated 2014-05-09.
Sponsored by Turku University Hospital · Observational
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.
The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.
676 studies on the registry are indexed under Prolapse; 79 are open to participants now.
This study's enrollment of 78 is below the median of 126 across 222 observational studies indexed under Prolapse.
Browse Prolapse studies →Turku University Hospital is the lead sponsor of 280 studies on the registry; 65 are open to participants now.
Counted across the registry records on this site, refreshed daily.
39 patients with pelvic organ prolapse and as controls 39 patients without prolapse.
Exclusion Criteria:
Patients, who were operated on because of pelvic organ prolapse.
Patients, who had hysterectomy due to other reasons than pelvic organ prolapse.
The elastin content in tissue samples in patients with or without pelvic organ prolapse.
Time frame: september 2012
The collagen content in tissue samples in women with or without pelvic organ prolapse.
Time frame: September 2012
This study is completed, as verified in May 2014. You cannot join it, but the record below documents what was studied.
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Turku University Hospital