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CompletedNCT01058161Updated Aug 28, 2014

High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

An interventional study of high-field MRI (3 Teslas) and high-field MRI (3 Teslas) in Abnormality, Inflammation and Rheumatism, sponsored by Assistance Publique Hopitaux De Marseille. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-08-28.

Sponsored by Assistance Publique Hopitaux De Marseille · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

02

Conditions studied

  • Abnormality
  • Inflammation
  • Rheumatism

Keywords

  • wrist and hand cartilage abnormalities in inflammatory and chronic rheumatisms
03

In context

Rheumatic Diseases

377 studies on the registry are indexed under Rheumatic Diseases; 79 are open to participants now.

This study's enrollment of 34 is below the median of 74 across 210 interventional studies indexed under Rheumatic Diseases.

Browse Rheumatic Diseases studies →

Lead sponsor

Assistance Publique Hopitaux De Marseille is the lead sponsor of 686 studies on the registry; 148 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • gp Suspects or affected by rheumatoid polyarthritis

    1. Morning articular Stiffness of at least 15 minutes.
    2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand.
    3. Possible rheumatoid Presence of a factor(mailman) and\or Antibody anti peptides positive citrullinés.
    4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations).

  • gp Affected by stiffening spondylitis with axial and peripheral infringement :

    . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers

  • gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis
  • gp Healthy control
  • gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion criteria

Exclusion Criteria:

  • Claustrophobia,
  • metallic foreign bodies,
  • pacemakers The pregnant women,
  • parturients or who breast-feed are excluded from the study
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
34 participants (actual)

Study arms

  • Other
    Suspects or affected by rheumatoid polyarthritis

    Other: high-field MRI (3 Teslas)

  • Other
    stiffening spondylitis with axial and peripheral infringement

    Other: high-field MRI (3 Teslas)

  • Other
    polyarthralgies with or without arthritis

    Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis

    Other: high-field MRI (3 Teslas)

  • Other
    Healthy control

    Other: high-field MRI (3 Teslas)

  • Other
    not inflammatory control

    Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

    Other: high-field MRI (3 Teslas)

Interventions

  • Otherhigh-field MRI (3 Teslas)

    high-field MRI (3 Teslas)

  • Otherhigh-field MRI (3 Teslas)

    high-field MRI (3 Teslas)

  • Otherhigh-field MRI (3 Teslas)

    high-field MRI (3 Teslas)

  • Otherhigh-field MRI (3 Teslas)

    high-field MRI (3 Teslas)

06

What researchers measure

Primary outcomes

  1. can be obtained, one could expect an early detection of joint abnormalities

    Time frame: 24 months

Secondary outcomes

  1. will be to develop a quantitative analyse of the corresponding high-resolution images.

    Time frame: 24 months

07

Study locations

1 site
  • Assistance Publique Hopitaux de Marseille
    Marseille, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 28, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01058161
Lead sponsor
Assistance Publique Hopitaux De Marseille
Responsible party
Sponsor
First posted
Jan 28, 2010
Start date
Dec 2009
Primary completion
Feb 2013
Completion
Feb 2013
Last update
Aug 28, 2014

Study contacts

sandrine guis, PU PH
principal investigator · Assistance Publique Hopitaux De Marseille

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.

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