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CompletedNCT01002937Updated Jun 18, 2024

Novel Prognostic Markers in Renal Cancer

An observational study in Renal Cell Carcinoma, sponsored by Royal Marsden NHS Foundation Trust. Completed at 1 site in United Kingdom. Per ClinicalTrials.gov, last updated 2024-06-18.

Sponsored by Royal Marsden NHS Foundation Trust · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
182
Sex
All
01

Study summary

The purpose of this project is to analyze tumour tissue from a group of subjects with renal cell carcinoma, who have been treated at the Royal Marsden Hospital.

Read the detailed description

Renal cancers have different clinical outcomes. The principal research objective is to study tumour tissue from renal cancer patients and try and understand why some cancers progress more rapidly than others. Further, another key aim of this study is to try and understand why some patients respond to treatment and others do not.

02

Conditions studied

  • Renal Cell Carcinoma

Keywords

  • Biomarkers
  • Prognosis response to treatment
  • Renal cancer
03

In context

Carcinoma, Renal Cell

1,965 studies on the registry are indexed under Carcinoma, Renal Cell; 378 are open to participants now.

This study's enrollment of 182 is above the median of 146 across 360 observational studies indexed under Carcinoma, Renal Cell.

Browse Carcinoma, Renal Cell studies →

Lead sponsor

Royal Marsden NHS Foundation Trust is the lead sponsor of 262 studies on the registry; 49 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Tumour tissue from subjects with renal cell carcinoma, who have been treated at the Royal Marsden Hospital

Inclusion criteria

  • The presence of histologically proven renal cell cancer
  • The availability of paraffin embedded tissue
  • Informed consent needed for tissue taken after January 2006 (date of enforcement of human tissue act)

Exclusion criteria

Exclusion Criteria:

  • Absence of histological tissue
  • Absence of consent to study tissue after January 2006
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
182 participants (actual)

Groups and cohorts

  • Tumour tissue, renal cell carcinoma

    \> 2mm x 2mm of tumour tissue obtained from paraffin blocks taken from biopsies or nephrectomy specimens.

06

What researchers measure

Primary outcomes

  1. The profiling of the expression of signal transduction biomarkers, gene expression, gene copy numbers and effect of mutations of the VHL gene in renal cancer and their relationship to clinical outcomes.

    Time frame: 5 years

07

Study locations

1 site
  • The Royal Marsden NHS Foundation Trust
    Sutton, Surrey SM2 5PT, United Kingdom
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 18, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01002937
Lead sponsor
Royal Marsden NHS Foundation Trust
Responsible party
RMH R&D (Professor Martin Gore, Royal Marsden NHS Foundation Trust) — Principal investigator
First posted
Oct 28, 2009
Start date
Dec 1, 2008
Primary completion
Dec 17, 2014
Completion
Dec 17, 2014
Last update
Jun 18, 2024

Study contacts

Professor Martin Gore
principal investigator · Royal Marsden NHS Foundation Trust

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.

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