An observational study in Pneumonia, sponsored by Mackay Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 86 Years. Per ClinicalTrials.gov, last updated 2009-09-15.
Sponsored by Mackay Memorial Hospital · Observational
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses. The aim of this study was to investigate the evolutional change of soluble TREM-1 (sTREM-1) in bronchoalveolar lavage (BAL) fluid of clinically diagnosed ventilator-associated pneumonia (VAP) and its correlation with response to treatment and outcome.
A prospective, interventional study conducted between August 2006 and August 2007 in MICU in Mackay Memorial Hospital, 35 patients with clinically diagnosed VAP were investigated. sTREM-1 was measured in BAL samples using ELISA at the onset, 4th - 5th and 7th - 9th day of clinical diagnosis of VAP.Of these 35 patients, 27 had positive BAL culture. The sTREM-1 levels in BAL fluid were measured and compared between patients with positive BAL culture and negative BAL culture. Serial changes in sTREM-1 levels were evaluated in relation to patient outcome.
2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.
This study's enrollment of 35 is below the median of 203 across 688 observational studies indexed under Pneumonia.
Browse Pneumonia studies →Mackay Memorial Hospital is the lead sponsor of 118 studies on the registry; 28 are open to participants now.
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Patients who were clinically suspected to have VAP were enrolled in the study. VAP was clinically diagnosed with a new infiltrate on a chest radiograph in a patient receiving mechanical ventilation for more than 48 hr with at least one of the following: purulent tracheal secretions, a body temperature >38°C or \<36°C, and leukocytosis (WBC > 10,000/mm³) or leukopenia (WBC \< 4000/mm³)
Exclusion Criteria:
Procedure: Bronchoscopy BAL
The bronchoscope was passed through endotracheal tube via a specific adaptor without topical anesthesia. The bronchoscope was introduced and wedged into the segmental bronchial orifice where pneumonia was suspected. Five aliquots of 20ml sterile saline were instilled and aspirated gently. The first aliquot was discarded and the last 4 aliquots were pooled for analysis. Part of the retrieved specimen in the first BAL fluid was sent to the laboratory immediately after collection for measurement of sTREM-1 level, the rest of sample was sent to microbiology lab for quantitative culture.
mortality
Time frame: 18 months
This study is completed, as verified in Sep 2009. You cannot join it, but the record below documents what was studied.
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Mackay Memorial Hospital