An interventional study of PSV - pressure suppot ventilation and NAVA - Neurally Adjusted Ventilatory Assist in Acute Lung Injury and Mechanical Ventilation, sponsored by University Hospital, Caen. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-02.
Sponsored by University Hospital, Caen · Not applicable, Interventional, and Basic science
Evaluation of a new ventilatory mode Neurally Adjusted Ventilatory Assist "NAVA" in patients who recover spontaneous breathing after acute lung injury.
Physiological evaluation of two modes of mechanical ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs Pressure Support Ventilation, at different levels of ventilator assistance.
Evaluation in term of physiological parameters: Tidal volume, Respiratory rate, Inspiratory effort, PaCO2, evaluation of subject-ventilator synchrony.
Evaluation of physiological response to varying levels of ventilator assistance.
989 studies on the registry are indexed under Acute Lung Injury; 156 are open to participants now.
This study's planned enrollment of 15 is below the median of 54 across 561 interventional studies indexed under Acute Lung Injury.
Browse Acute Lung Injury studies →University Hospital, Caen is the lead sponsor of 505 studies on the registry; 80 are open to participants now.
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Exclusion Criteria:
Device: PSV - pressure suppot ventilation
Spontaneous Breathing using Neurally Adjusted Ventilatory Assist with flow triggering
Device: NAVA - Neurally Adjusted Ventilatory Assist
Spontaneous Breathing using Neurally Adjusted Ventilatory Assist with trigger adjusted on diaphragmatic electromyogram
Device: NAVA - EMG
Gold standard partial ventilator support: Pressure Support Ventilation performed with Servo-i® ventilator (MAQUET,Critical Care, Sweden). Different levels of pressure support ventilator assistance are tested.
Also known as: PSV
Partial ventilator support with new partial ventilation mode (NAVA) performed with Servo-i® ventilator (Maquet,Critical Care, Sweden). Different levels of neurally adjusted ventilatory assist are tested. Positive pressure, delivered by the machine, is driven using inspiratory flow trigger.
Also known as: NAVA - Flow
Partial ventilator support with new partial ventilation mode (NAVA) performed with Servo-i® ventilator (Maquet,Critical Care, Sweden). Different levels of neurally adjusted ventilatory assist are tested. The machine applies positive pressure throughout inspiration in proportion to the electrical activity of the diaphragm (Eadi). Eadi was obtained trhough a naso-gastric tube with multiple array of electrodes placed at its distal end (Eadi catheter® , Maquet Critical Care, Sweden).
Comparison of physiologic response to varying levels of pressure support and Neurally Adjusted Ventilatory Assist (NAVA)
Time frame: 24 hours
Subject-ventilator synchrony
Time frame: 24 hours
This study is completed, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.
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University Hospital, Caen