CClinicalTrials.gg
RecruitingNCT00901602LIPSPUpdated Feb 3, 2023

Lebanese Interhospital Pneumococcal Surveillance Program

An observational study in Pneumonia, Meningitis and Sepsis, sponsored by American University of Beirut Medical Center. Recruiting at 1 site in Lebanon. Open to participants aged 1 Day and older. Per ClinicalTrials.gov, last updated 2023-02-03.

Sponsored by American University of Beirut Medical Center · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
700
Ages
1 Day and older
Sex
All
01

Study summary

Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.

02

Conditions studied

  • Pneumonia
  • Meningitis
  • Sepsis
  • Bacteremia

Keywords

  • streptococcus pneumoniae
  • pneumococcus
  • pneumonia
  • meningitis
  • serotypes
  • bacteremia
  • sepsis
03

Who can participate

Ages eligible
1 Day and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

patients with invasive pneumococcal disease with positive culture of S. pneumoniae from a normally sterile site (blood, CSF, etc.)

Inclusion criteria

  • Samples included in the study are those that are:

    • culture proven
    • invasive pneumococcal infections
    • in patients of all ages admitted to different hospitals all over Lebanon
  • Acceptable samples include:

    • positive isolates from blood
    • cerebrospinal fluid
    • other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration

Exclusion criteria

Exclusion Criteria:

  • non S. pneumoniae isolates
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
700 participants (estimated)
Biospecimen retention
Samples with dna
05

What researchers measure

Primary outcomes

  1. Serotype prevalence of S. pneumoniae in invasive pneumococcal disease

    Time frame: yearly

Secondary outcomes

  1. Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes

    Time frame: yearly

06

Study locations

1 of 1 sites recruiting
  • American University of Beirut
    Beirut, 113-6044, Lebanon
    • Ghassan S Dbaibo, M.D. · Contact · gdbaibo@aub.edu.lb · +961-1-749235
    • Carelle Tabet, R.N. · Contact · cnt03@aub.edu.lb · +961-3-860129
    • Ghassan S Dbaibo, M.D. · Principal investigator
    Recruiting
07

Registry details

Key details

Study ID
NCT00901602
Lead sponsor
American University of Beirut Medical Center
Collaborators
PneumoADIP, Pfizer
Responsible party
Dr. Ghassan Dbaibo (Professor, American University of Beirut Medical Center) — Principal investigator
First posted
May 14, 2009
Start date
Oct 2005
Primary completion
Oct 2030 (estimated)
Completion
Oct 2030 (estimated)
Last update
Feb 3, 2023

Study contacts

Ghassan S Dbaibo, M.D.
Contact
gdbaibo@aub.edu.lb
+961-1-749235 ext. 5440
Mireille Lteif, RN
Contact
ml12@aub.edu.lb
+961-1-350000 ext. 5752
Ghassan S Dbaibo, M.D.
principal investigator · American University of Beirut Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Interested in this study?

Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.

Contact study team

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion