An observational study in Coronary Artery Disease, sponsored by Fudan University. Status unknown at 1 site in China. Per ClinicalTrials.gov, last updated 2008-10-27.
Sponsored by Fudan University · Observational
The recognition of the association between circulating C-reactive protein (CRP) levels and risk of coronary heart disease (CHD) has led to an increased emphasis on CRP genetic effects on CRP level and CHD. However, the causality of CRP variants remains uncertain.The objective of this study is to evaluate the association of CRP gene variants and CRP levels in CHD in Chinese Han population. We conduct case-control study in CRP-Han study participants. The common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels are detected. A Mendelian randomization analysis will be used to help test the likelihood of causal association of gene-CRP levels, CRP levels-CHD and gene-CHD. The investigators hypothesize that CRP gene variants influence the protein level and may participate in CHD progress.
CHD patients and non-CHD population are recruited. CRP level and CHD severity by coronary angiograph will be examined. Mendelian randomization analysis are taken to analyze statically.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 336 across 1,947 observational studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Fudan University is the lead sponsor of 1,270 studies on the registry; 623 are open to participants now.
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in-hospital patients and community healthy individual
Exclusion Criteria:
patients without coronary artery disease
patients with coronary artery disease
This study is status unknown, as verified in Oct 2008. You cannot join it, but the record below documents what was studied.
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Fudan University