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CompletedNCT00655447Updated Apr 9, 2008

Examining the Long-Term Risks of Oophorectomy

An observational study in Coronary Heart Disease, Stroke and Breast Cancer, sponsored by Parker, William H., M.D.. Completed at 1 site in United States. Open to female participants aged 30 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-04-09.

Sponsored by Parker, William H., M.D. · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
32,175
Ages
30 Years to 55 Years
Sex
Female
01

Study summary

At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.

Read the detailed description

We are conducting a prospective, observational study of 32,175 women participants of the Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are evaluating mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

02

Conditions studied

  • Coronary Heart Disease
  • Stroke
  • Breast Cancer
  • Ovarian Cancer
  • Cancer
  • Hip Fracture
  • Death

Keywords

  • oophorectomy
  • ovarian conservation
  • stroke
  • breast cancer
  • ovarian cancer
  • other cancer
  • hip fracture
03

In context

Ovarian Neoplasms

2,695 studies on the registry are indexed under Ovarian Neoplasms; 727 are open to participants now.

This study's enrollment of 32,175 is above the median of 200 across 527 observational studies indexed under Ovarian Neoplasms.

Browse Ovarian Neoplasms studies →

Lead sponsor

This is the only study on the registry with Parker, William H., M.D. as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 55 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Nurses' Health Study I, which included 122,701 married registered nurses living in 11 U.S. states and who were ages 30 to 55 in 1976

Inclusion criteria

  • Women who had hysterectomies were classified into simple hysterectomy or hysterectomy with both ovaries removed.

Exclusion criteria

Exclusion Criteria:

  • Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip fracture before entering the study were excluded. Cancer as an indication for hysterectomy also excluded.
  • Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of hysterectomy, or those who had oophorectomy before hysterectomy were excluded.
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
32,175 participants (actual)

Groups and cohorts

  • 1

    all women having a hysterectomy with oophorectomy

  • 2

    all women having a hysterectomy without removal of ovaries

06

What researchers measure

Primary outcomes

  1. mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

    Time frame: 28 years

Secondary outcomes

  1. The effect of postmenopausal hormone use on mortality and morbidity due to the following conditions: coronary heart disease, stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.

    Time frame: 28 years

07

Study locations

1 site
  • Parker, Rosenman, Rodi Gynecology Group
    Santa Monica, California 90401, United States
08

References and documents

Publications

  • Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol. 2005 Aug;106(2):219-26. doi: 10.1097/01.AOG.0000167394.38215.56. PubMed 16055568 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 9, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00655447
Lead sponsor
Parker, William H., M.D.
Collaborators
Ethicon, Inc.
First posted
Apr 9, 2008
Start date
Jan 1980
Primary completion
Jun 2004
Completion
Jun 2004
Last update
Apr 9, 2008

Study contacts

William H Parker, MD
principal investigator · Saint John's Cancer Institute

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2008. You cannot join it, but the record below documents what was studied.

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