An interventional study of Hypoxic Exposure in Pulmonary Edema, sponsored by Heidelberg University. Completed at 1 site in Germany. Open to participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-01-30.
Sponsored by Heidelberg University · Not applicable and Interventional
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE). Since these parameters are only indirect measures of pulmonary interstitial fluid accumulation, the aim of this study is to examine the effects of broncho-constriction on the increase of closing volume by extensive lung function testing in healthy mountaineers at low altitude and on the Margherita Hut (4559 m). As has been done in earlier studies, conventional thorax radiographs are used for verification of HAPE. In this study, the determination of the thoracic fluid quantity will be completed by measurements of thoracic impedance. In addition markers of pulmonary endothelial function will be assessed to get further insight into the regulation of pulmonary vascular tone at altitude and in particular into the pathophysiology of HAPE.
138 studies on the registry are indexed under Pulmonary Edema; 24 are open to participants now.
This study's enrollment of 34 is below the median of 68 across 72 interventional studies indexed under Pulmonary Edema.
Browse Pulmonary Edema studies →Heidelberg University is the lead sponsor of 279 studies on the registry; 17 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
high altitude exposure
Other: Hypoxic Exposure
ascent to 4559 m within 24 h without prior acclimatization
development of HAPE
Time frame: during the 48 h stay at altitude
change of lung function parameters from low to high altitude
Time frame: during the 48 h stay at altitude
markers of pulmonary endothelial function
Time frame: during the 48 h stay at altitude
quantification of pulmonary interstitial fluid
Time frame: during the 48 h stay at altitude
This study is completed, as verified in Nov 2007. You cannot join it, but the record below documents what was studied.
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Heidelberg University