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CompletedNCT00396110Updated Nov 6, 2006

Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET)

An observational study in Hypercholesterolemia and Coronary Heart Disease, sponsored by AstraZeneca. Completed. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2006-11-06.

Sponsored by AstraZeneca · Observational

Study type
Observational
Model
Defined population
Time perspective
Prospective
Enrollment
3,889
Ages
18 Years to 75 Years
Sex
All
01

Study summary

In this study the effect of the switch to rosuvastatin from another statin (fluvastatin, pravastatin, simvastatin, atorvastatin) was evaluated in high-risk patients with and without evident CHD and LDL-C ≥ 3.2 mmol/l. This was done in a large observational study (TARGET) representing daily practice. Primary end points analysis was the percentage of patients reaching the target of LDL-C \< 3.2 mmol/l. Secondary outcomes were the changes of LDL-C, HDL-C, TC, Triglycerides (TG) and TC/HDL-C-ratio from baseline.

02

Conditions studied

  • Hypercholesterolemia
  • Coronary Heart Disease

Keywords

  • cholesterol
  • coronary heart disease
  • rosuvastatin
  • LDL-C goal
  • hypercholesterolemia
03

In context

Heart Diseases

3,639 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.

This study's enrollment of 3,889 is above the median of 294 across 1,241 observational studies indexed under Heart Diseases.

Browse Heart Diseases studies →

Lead sponsor

AstraZeneca is the lead sponsor of 3,429 studies on the registry; 270 are open to participants now.

Of its 357 completed or terminated interventional studies of FDA-regulated products, 173 (48%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • High-risk patients with and without evident CHD who had LDL-C > 3.2 mmol/l and were treated at that moment with HMG-CoA-reductase inhibitor apart from rosuvastatin.
  • Patients were aged >18 years and \<70 years (men) and \< 75 years (women).

Exclusion criteria

Exclusion Criteria:

  • Treatment with atorvastatin 40 or 80 mg or simvastatin 80 mg
  • Patients familiar with muscular pain, myopathy or liver function disorders (inclusive elevation of serum transaminases) and/or contra-indications for treatment with rosuvastatin
05

Study design

Observational model
Defined population
Time perspective
Prospective
Enrollment
3,889 participants
06

Study locations

No study locations are listed for this record.

07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 6, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00396110
Lead sponsor
AstraZeneca
First posted
Nov 6, 2006
Start date
Feb 2003
Last update
Nov 6, 2006

Study contacts

Ingrid van Geel, MD
study chair · AstraZeneca
Ingeborg Vosjan, MD
study chair · AstraZeneca
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2003. You cannot join it, but the record below documents what was studied.

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