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CompletedNCT00330577Updated May 12, 2014

24-Hour Intraocular Pressure (IOP) And Blood Pressure Control In Glaucoma And Ocular Hypertension Patients

A Phase 4 interventional study of timolol maleate 0.5% and latanoprost/timolol fixed combination in Primary Open Angle Glaucoma and Ocular Hypertension, sponsored by Aristotle University Of Thessaloniki. Completed at 1 site in Greece. Open to participants aged 29 Years to 80 Years. Per ClinicalTrials.gov, last updated 2014-05-12.

Sponsored by Aristotle University Of Thessaloniki · Phase 4, Interventional, and Treatment

Phase
Phase 4
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
29 Years to 80 Years
Sex
All
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Study summary

The purpose of this study is to compare the short-term mean 24-hour intraocular pressure control, 24-hour blood pressure effect and safety of Latanoprost/Timolol fixed combination given once in the evening with placebo once in the morning versus timolol maleate 0.5% given twice daily in patients with ocular hypertension and primary open-angle glaucoma.

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Conditions studied

  • Primary Open Angle Glaucoma
  • Ocular Hypertension
03

In context

Glaucoma

1,818 studies on the registry are indexed under Glaucoma; 231 are open to participants now.

This study's enrollment of 30 is below the median of 65 across 1,272 interventional studies indexed under Glaucoma.

Browse Glaucoma studies →

Lead sponsor

Aristotle University Of Thessaloniki is the lead sponsor of 274 studies on the registry; 56 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
29 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • POAG
  • OHT

Exclusion criteria

Exclusion Criteria:

  • Advanced glaucoma
  • Arterial Hypertension
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double
Enrollment
30 participants

Interventions

  • Drugtimolol maleate 0.5%
  • Druglatanoprost/timolol fixed combination
  • Drugplacebo (artificial tears)
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Study locations

1 site
  • Glaucoma Unit, A University Dept of Ophthalmology, AHEPA Hospital
    Thessaloniki, 546 36, Greece
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 12, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00330577
Lead sponsor
Aristotle University Of Thessaloniki
Responsible party
AGP Konstas (Professor in Ophthalmology, Aristotle University Of Thessaloniki) — Principal investigator
First posted
May 29, 2006
Start date
Apr 2006
Primary completion
Apr 2007
Completion
Jul 2007
Last update
May 12, 2014

Study contacts

AGP Konstas, MD, PhD
principal investigator · Glaucoma Unit, A University Dept of Ophthalmology, AHEPA Hospital
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2014. You cannot join it, but the record below documents what was studied.

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