An observational study in Atherosclerosis, Cardiovascular Diseases and Heart Diseases, sponsored by Tufts Medical Center. Completed. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2015-12-02.
Sponsored by Tufts Medical Center · Observational
To determine the rate of progression of sub-clinical cardiovascular disease as measured in carotid intimal medial thickness over a period of 8 to 10 years.
BACKGROUND:
Strong associations exist between cardiovascular events and increased carotid artery wall intima-media thickness (IMT) as measured non-invasively by carotid ultrasound. Carotid IMT is accepted as a surrogate marker of sub-clinical cardiovascular disease.The study will determine the rate of progression of sub-clinical cardiovascular disease (change in IMT) over a period of 8 to 10 years.
DESIGN NARRATIVE:
The study will determine the rate of progression of sub-clinical cardiovascular disease (change in intimal medial thickness {IMT}) over a period of 8 to 10 years. Imaging and IMT measurements of approximately 2800 to 3000 members of the Framingham Offspring cohort having had baseline IMT measurements at their 1995-98 clinic visit will be repeated in 2005-2007. The principal aims of the project are to study the primary hypotheses that: 1. Interim exposure to traditional cardiovascular risk factors measured over 50 years is positively associated with the progression rate of carotid IMT. 2. Baseline carotid IMT and cumulative exposure to cardiovascular risk factors 20 years before the baseline visit are a better predictor of progression of sub-clinical disease after 8 to 10 years than the interim exposure to risk factors. 3. Novel risk factors such as C-reactive protein and homocysteine affect progression of carotid atherosclerosis more than traditional risk factors. This study will add a phenotypic marker of site-specific change in sub-clinical cardiovascular disease to the Framingham Study database. This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers
1,596 studies on the registry are indexed under Atherosclerosis; 262 are open to participants now.
This study's enrollment of 2,900 is above the median of 230 across 581 observational studies indexed under Atherosclerosis.
Browse Atherosclerosis studies →Tufts Medical Center is the lead sponsor of 200 studies on the registry; 29 are open to participants now.
Of its 31 completed or terminated interventional studies of FDA-regulated products, 16 (52%) have results posted.
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Community based in Framingham MA
No eligibility criteria
Cardiovascular Morbidity
Longitudinal follow-up of community based cohort
Time frame: Longitudinal follow-up
No study locations are listed for this record.
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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