National Institutes of Health: Infections trials

The registry lists 375 Infections studies with National Institutes of Health as lead sponsor. 16 are open to participants now and 43 have results posted.

Phase 1 89Phase 2 100Phase 3 47Phase 4 7No phase 144(a study in two phases counts in both)

Studies

Page 4 of 4. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIVCompletedNCT00000940Phase 2
• Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048CompletedNCT00000933
• A Study of Nonoxynol-9 (N-9) and HIV InfectionCompletedNCT00000926Phase 3
• The Effects of Prednisone on HIV Levels and the Immune SystemCompletedNCT00000921Phase 2
• A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV InfectionCompletedNCT00000919Not applicable
• A Study to Compare Two Anti-HIV Combination Therapies Each Containing Saquinavir in HIV-Positive ChildrenCompletedNCT00000913Phase 2
• A Study to Monitor Patients With Primary or Early HIV InfectionCompletedNCT00000911
• A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV TherapyCompletedNCT00000909Phase 2
• Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected ChildrenCompletedNCT00000901Phase 1
• A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV InfectionCompletedNCT00000895Not applicable
• A Study to Evaluate the Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3CompletedNCT00000889Phase 2
• Long-Term Assessment for Metabolic, Cardiovascular and Neurologic Problems in HIV-Infected Patients With Increased CD4 Cells Counts Following Anti-HIV TherapyCompletedNCT00000883Not applicable
• A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) DiseaseWithdrawnNCT00000881Phase 1
• Controlled Clinical Trial of Antiviral Cytotoxic T Lymphocyte (CTL) Infusion Following Combination Antiretroviral Drug Therapy for Asymptomatic HIV-1 InfectionTerminatedNCT00000875Not applicable
• Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV InfectionCompletedNCT00000872Phase 2
• A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART AloneCompletedNCT00000870Phase 2
• The Safety and Effects of 1592U89 Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Infants and ChildrenCompletedNCT00000865Phase 1
• A Study of WR 6026 in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected PatientsCompletedNCT00000863Phase 2
• The Effects of Treatment for Mycobacterium Avium Complex (MAC) on the Cells of HIV-Infected PatientsCompletedNCT00000860
• Detection of Human Immunodeficiency Virus Type 1 (HIV-1) in Vaginocervical Secretions: Correlation With Clinical Status, Virologic and Immunologic Parameters, and the Presence of Other InfectionsCompletedNCT00000858
• A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease.WithdrawnNCT00000856Phase 1
• A Pilot Study of Allogeneic Lymphocyte Transfer in HIV InfectionCompletedNCT00000852Not applicable
• The Safety and Effectiveness of Adefovir Dipivoxil in HIV-Infected ChildrenCompletedNCT00000843Phase 1
• A Study of Indinavir Sulfate Plus Zidovudine (AZT) Plus Lamivudine in HIV-Infected Patients Who Have Taken AZT for Six or More MonthsCompletedNCT00000841Phase 3
• A Phase I Study of Methotrexate for HIV InfectionCompletedNCT00000834Phase 1
• A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected InfantsCompletedNCT00000829Phase 1
• Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine MetabolitesCompletedNCT00000826Phase 1
• The Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3CompletedNCT00000825Phase 2
• A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 InfectionCompletedNCT00000823Phase 2
• A Phase II Study of Low-Dose Interleukin-2 by Subcutaneous Injection in Combination With Antiretroviral Therapy Versus Antiretroviral Therapy Alone in Patients With HIV-1 Infection and at Least 3 Months Stable Antiretroviral TherapyCompletedNCT00000820Phase 2
• A Phase I, Placebo-Controlled, Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Thalidomide in Subjects With HIV-1 InfectionCompletedNCT00000812Phase 1
• A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive ChildrenCompletedNCT00000811Phase 2
• A Pharmacokinetic and Tolerance Study of Oral Ganciclovir in HIV-Infected Children With Asymptomatic Cytomegalovirus Infection and Low CD4 Cell Counts or Quiescent Cytomegalovirus DiseaseCompletedNCT00000805Phase 1
• A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV InfectionCompletedNCT00000793Phase 2
• Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV InfectionCompletedNCT00000790Phase 2
• A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV InfectionCompletedNCT00000789Phase 2
• Pilot Study to Evaluate the Efficacy of Zidovudine in Preventing CD4+ Lymphocyte Decline in Patients With Primary HIV Infection. (One Treatment Arm Receives Placebo)CompletedNCT00000765Not applicable
• Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.CompletedNCT00000764Phase 1
• A Placebo-Controlled, Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant Envelope Proteins of HIV-1 gp160 and gp120 in Children >= 1 Month Old With Asymptomatic HIV InfectionCompletedNCT00000762Phase 1
• A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV InfectionCompletedNCT00000760Phase 1
• Neurodevelopmental and Neurological Study of Infants and Children With HIV-1 Infection and AIDS in Clinical TrialsCompletedNCT00000759
• A Randomized Phase II Study of Two Doses of Interferon Alfa-2a (IFN Alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3CompletedNCT00000754Phase 2
• Preventing Frequent Sinus Infections in HIV-Infected PatientsWithdrawnNCT00000752Phase 2
• A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV InfectionCompletedNCT00000750Phase 3
• Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV InfectionCompletedNCT00000739Phase 1
• Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency SyndromeCompletedNCT00000726Phase 1
• A Double-Blind, Placebo-Controlled Trial To Evaluate Intravenous Gamma Globulin in Children With Symptomatic HIV Infection Receiving ZidovudineCompletedNCT00000720Phase 3
• A Multicenter Trial To Evaluate Oral Retrovir in the Treatment of Children With Symptomatic HIV InfectionCompletedNCT00000716Phase 2
• A Multicenter, Double Blind, Comparative Study of Zidovudine Alone Versus Zidovudine and Acyclovir as Treatment for HIV-Infected Patients With CD4+ Counts Less Than 200 Cells/mm3CompletedNCT00000712Phase 2
• Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical SymptomsCompletedNCT00000707Not applicable
• Safety and Effectiveness of Azidothymidine (AZT) in HIV-Positive Patients With HemophiliaCompletedNCT00000705Phase 1
• A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) InfectionCompletedNCT00000702Phase 3
• A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCPCompletedNCT00000700Phase 3
• A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV RetinitisCompletedNCT00000698Phase 3
• A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use GanciclovirWithdrawnNCT00000697Phase 2
• A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment FailureCompletedNCT00000691Phase 2
• Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)CompletedNCT00000676Phase 3
• A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic TherapyCompletedNCT00000673Phase 1
• A Phase II Efficacy Study Comparing 2',3'-Dideoxyinosine (ddI) (BMY-40900) and Zidovudine Therapy of Patients With HIV Infection Who Have Been on Long Term Zidovudine TreatmentCompletedNCT00000671Phase 2
• A Phase I Safety and Pharmacokinetics Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Infants and Children With AIDS or Symptomatic HIV InfectionCompletedNCT00000669Phase 1
• A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral GanciclovirCompletedNCT00000668Phase 1
• A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii InfectionCompletedNCT00000666Not applicable
• Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir ComponentCompletedNCT00000665Not applicable
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in Infants and Children With Documented HIV-1 InfectionCompletedNCT00000663Phase 1
• The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAUCompletedNCT00000654Phase 2
• A Trial of Two Doses of 2',3'-Dideoxycytidine (ddC) in the Treatment of Children With Symptomatic HIV Infection Who Are Intolerant of AZT and/or Who Show Progressive Disease While on AZTCompletedNCT00000653Phase 2
• A Phase I Study to Evaluate the Safety and Toxicity of the Combination of Zidovudine and 2',3'-Dideoxyinosine (Didanosine) in Children With HIV InfectionCompletedNCT00000652Phase 1
• A Randomized, Double Blind, Comparative Study of Dideoxycytidine (ddC) Alone or ddC/AZT Combination Versus Zidovudine (ZDV) Alone in Patients With HIV Infection Who Have Received Prior ZDV TherapyCompletedNCT00000651Phase 3
• An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV InfectionCompletedNCT00000647Not applicable
• A Phase II Safety and Efficacy Study of Clarithromycin in the Treatment of Disseminated M. Avium Complex (MAC) Infections in Patients With AIDSCompletedNCT00000644Phase 2
• A Phase II/III Trial of Rifampin, Ciprofloxacin, Clofazimine, Ethambutol, and Amikacin in the Treatment of Disseminated Mycobacterium Avium Infection in HIV-Infected Individuals.CompletedNCT00000641Phase 2
• Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous InfectionCompletedNCT00000638Not applicable
• Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous InfectionCompletedNCT00000636Not applicable
• Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical TrifluridineCompletedNCT00000635Not applicable
• Viral Activation Transfusion Study (VATS)CompletedNCT00000593Not applicable