An interventional study of Simvastatin in Hypercholesterolemia, sponsored by Hadassah Medical Organization. Status unknown at 1 site in Israel. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-03-11.
Sponsored by Hadassah Medical Organization · Not applicable and Interventional
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2. There have been many studies demonstrating the bone-promoting effect of local application various animal models including after application into socket of teeth in a rat. the purpose of the study is to investigate the effect of slow release topical simvastatin in socket of mandibular teeth on bone remodeling in the socket
after extraction of mandibular single root teeth 10 mg of slow release simvastatin would be inserted to the socket. observation will be at 1 week, 4 weeks and 3 months.after 3 months the patients will have dental CT as done routinely in our clinic before placing dental implants and the bone density and height will be measured on this data. during the procedure of inserting a dental implant a trephine will be taken for histology.
1,238 studies on the registry are indexed under Hypercholesterolemia; 109 are open to participants now.
This study's planned enrollment of 20 is below the median of 99 across 991 interventional studies indexed under Hypercholesterolemia.
Browse Hypercholesterolemia studies →Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.
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Exclusion Criteria:
simvastatin will be inserted to sockets
Drug: Simvastatin
sockets will be left to healing without material in socket
Drug: Simvastatin
10 mg simvastatin, slow release in socket of extracted tooth (single application only)
bone height and density in former socket
measured on CT
Time frame: 3 months
bone mineralization
histology from bone in former socket
Time frame: 3 months
This study is status unknown, as verified in Mar 2010. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization