Protein Kinase Inhibitors: all 15,766 studies that test it
Page 135 of 158. Open to participants first (2,605), then studies with results posted, then the rest; newest registration first within each.
- A Safety Study of Oral ZSTK474 in Patients With CancerCompletedNCT01280487Phase 1
- Study to Evaluate Nilotinib in Adult Patients With Imatinib-resistant or Imatinib-intolerant Chronic Myelogenous Leukemia (CML), or Relapse/Refractory Ph+ Acute Lymphoblastic Leukemia (ALL) (Extension Study)CompletedNCT01279473Phase 1/2
- First-in-Human Single Ascending and Multiple Dose of GLPG0778CompletedNCT01278108Phase 1
- Comparison of Immunosuppression on Progression of Arteriosclerosis in Renal TransplantationTerminatedNCT01276834Phase 4
- Effects of Administration of Fostamatinib on Blood Concentrations of an Oral Contraceptive in Healthy Female SubjectsCompletedNCT01276262Phase 1
- Sorafenib Tosylate and Stereotactic Radiosurgery in Treating Patients With Brain MetastasesCompletedNCT01276210Phase 1
- Neoadjuvant Combined Endocrine and HER2 Target Therapy in Postmenopausal Women With ER and Her2 Positive Breast CancerCompletedNCT01275859Phase 2
- Axitinib as Second-line Treatment for Advanced Hepatocellular CarcinomaCompletedNCT01273662Phase 2
- Palomid 529 in Patients With Neovascular Age-Related Macular DegenerationCompletedNCT01271270Phase 1
- Glivec® Plus m-FOLFOX Avastin® in Advanced Colorectal CancerTerminatedNCT01271166Phase 1
- Safety of CHIR-258 (TKI258) in Advanced Solid TumorsTerminatedNCT01270906Phase 1
- Tasigna Neoadjuvant Gastrointestinal Stromal Tumor (GIST)WithdrawnNCT01270893Phase 2
- Whole Soy and Daidzein on Reduction of Blood Pressure in Postmenopausal Chinese WomenStatus unknownNCT01270737Not applicable
- A Study of Apatinib in Patients With Advanced Non-squamous and Non-small Cell Lung CancerCompletedNCT01270386Phase 2
- Immediate Conversion From Tacrolimus to Everolimus in Stable Maintenance Renal Transplant RecipientsWithdrawnNCT01269684Phase 4
- Efficacy of NF-kB Inhibition for Reducing Symptoms During Maintenance Therapy in Multiple Myeloma PatientsWithdrawnNCT01269203Phase 2
- Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal TumorCompletedNCT01267695Phase 2
- An Open Label Study To Investigate the Pharmacokinetics and Pharmacodynamics of Repeat Escalating Doses of the Oral AKT Inhibitor GSK2141795 by 18F FDG PET Analysis in Subjects With Ovarian CancerCompletedNCT01266954Phase 1
- Open Label, Single Arm Trial to Characterize Patients With Metastatic RCC Treated With Everolimus After Failure of the First VEGF-targeted Therapy (MARC-2)CompletedNCT01266837Phase 4
- Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V MutationCompletedNCT01266369Phase 2
- Sirolimus or Vorinostat and Hydroxychloroquine in Advanced CancerCompletedNCT01266057Phase 1
- Efficacy and Safety of Bevacizumab/Temsirolimus Combination to Treat Advanced Renal Cell CarcinomaTerminatedNCT01264341Phase 2
- Study of Everolimus and Sorafenib in Patients With Advanced Thyroid Cancer Who Progressed on Sorafenib AloneStatus unknownNCT01263951Phase 2
- A Safety and Efficacy Study of SB1518 for the Treatment of Advanced Lymphoid MalignanciesCompletedNCT01263899Phase 2
- MK2206 and Paclitaxel in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Metastatic Breast CancerCompletedNCT01263145Phase 1
- An Absorption, Distribution, Metabolism and Excretion (ADME) Study of Single Oral Dose [14C] GSK2118436 in Subjects With BRAF Mutant Solid TumorsCompletedNCT01262963Phase 1
- Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural EffusionTerminatedNCT01262612Phase 2
- Study of Oxaliplatin and Sorafenib Combination to Treat Gastric Cancer Relapsed After a Cisplatin Based TreatmentCompletedNCT01262482Phase 2
- Evaluating Lapatinib + Capecitabine in Patients Aged 70 and Over With HER2 Metastatic Breast Cancer.CompletedNCT01262469Phase 2
- A Dose Finding Study of TKM-080301 Infusion in Neuroendocrine Tumors (NET) and Adrenocortical Carcinoma (ACC) PatientsCompletedNCT01262235Phase 1/2
- Clinical Trial Investigating Pazopanib in Patients With Platinum-resistant Advanced Ovarian CancerCompletedNCT01262014Phase 2
- Study of Nilotinib Efficacy in Pigmented Villo-Nodular Synovitis/ Tenosynovial Giant Cell Tumour (PVNS/TGCT)CompletedNCT01261429Phase 2
- Clinical Study of Sorafenib and Zoledronic Acid to Treat Advanced HCCStatus unknownNCT01259193Phase 2
- Carboplatin/Taxol/Ridaforolimus in Endometrial, Ovarian and SolidsCompletedNCT01256268Phase 1
- A Study of AMG 337 in Subjects With Advanced Solid TumorsCompletedNCT01253707Phase 1
- Phase 1 and 2 Study of PX-866 and CetuximabCompletedNCT01252628Phase 1/2
- Nilotinib for Cytomegalovirus Prophylaxis and Treatment After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT01252017Phase 2
- A Study of ARQ 197 in Combination With ErlotinibCompletedNCT01251796Phase 1
- Combination With Gemcitabine in Advanced Pancreatic CancerCompletedNCT01251640Phase 1/2
- BIBF 1120 in Recurrent Glioblastoma MultiformeCompletedNCT01251484Phase 2
- Hepatocellular Carcinoma (HCC)_Torisel_CompletedNCT01251458Phase 1/2
- Formulation Comparison in Normal VolunteersCompletedNCT01250197Phase 1
- Nasopharyngeal Carcinoma (NPC) AxitinibCompletedNCT01249547Phase 2
- MK-2206 for Recurrent Malignant GliomaWithdrawnNCT01249105Phase 2
- Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK2126458 and GSK1120212 Combination Therapy in Subjects With Advanced Solid Tumors.TerminatedNCT01248858Phase 1
- PhIb BKM120 or BEZ235+Endocrine Treatment in Post-Menopausal Patients With Hormone Receptor + Metastatic Breast CancerCompletedNCT01248494Phase 1
- A Randomized, Double Blind Study Evaluating Paclitaxel With and Without RAD001 in Patients With Gastric Carcinoma After Prior ChemotherapyCompletedNCT01248403Phase 3
- Temsirolimus-RCC-imagingStatus unknownNCT01246817Phase 2
- A Study of Fostamatinib in Subjects With Impaired Kidney FunctionCompletedNCT01245790Phase 1
- A Phase 0 of Neoadjuvant Lapatinib in Infiltrative Bladder Carcinoma Before CystectomyTerminatedNCT01245660Early Phase 1
- Akt Inhibitor MK2206 in Combination With Lapatinib Ditosylate in Patients With Advanced or Metastatic Solid Tumors or Breast CancerCompletedNCT01245205Phase 1
- Study of FP-1039 in Subjects With Endometrial CancersWithdrawnNCT01244438Phase 2
- Sunitinib Malate and Bevacizumab in Treating Patients With Kidney Cancer or Advanced Solid MalignanciesCompletedNCT01243359Phase 1
- Study of Crenolanib for the Treatment of Patients With Advanced GIST With the D842-related Mutations and Deletions in the PDGFRA GeneCompletedNCT01243346Phase 2
- Everolimus for Patients With Relapsed/Refractory Germ Cell CancerCompletedNCT01242631Phase 2
- ABC-04 a Study of Cisplatin, Gemcitabine and Selumetinib in Patients With Advanced Biliary Tract CancerCompletedNCT01242605Phase 1
- Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess BlastsCompletedNCT01241500Phase 3
- Trial of MK-2206 + Endocrine Treatment in Patients With Hormone Receptor Positive Breast CancerWithdrawnNCT01240941Phase 2
- Exploratory Study of XL765 (SAR245409) or XL147 (SAR245408) in Subjects With Recurrent Glioblastoma Who Are Candidates for Surgical ResectionCompletedNCT01240460Phase 1
- E7080 Food Effect Study in Healthy SubjectsCompletedNCT01240408Phase 1
- A Study to Determine the Relative Bioavailability of a Tablet Formulation of GDC-0941 and the Effect of Ketoconazole on the Pharmacokinetics of the GDC-0941 TabletCompletedNCT01240226Phase 1
- Study of SGI-1776, a PIM Kinase Inhibitor, in Subjects With Relapsed/Refractory LeukemiasWithdrawnNCT01239108Phase 1
- Phase I/II Study of Pazopanib and Cyclophosphamide in Patients With Platinum-resistant Recurrent Ovarian CancerCompletedNCT01238770Phase 1/2
- Sunitinib + Docetaxel as Second-line Treatment in Gastric CancerCompletedNCT01238055Phase 2
- Dose Finding Study for Combination of Capecitabine, Lapatinib and Vinorelbine in Metastatic Breast CancerTerminatedNCT01238029Phase 1
- A Trial of LEE011 in Patients With Advanced Solid Tumors or Lymphoma.CompletedNCT01237236Phase 1
- Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)CompletedNCT01236638Phase 2
- A Trial to Establish the Feasibility of Combining Either the Tyrosine Kinase Inhibitor AC220,CXCR4 Inhibitor Plerixafor or HSP90 Inhibitor Ganetespib With Chemotherapy in Older Patients With Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome.CompletedNCT01236144Phase 1/2
- A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid TumorsCompletedNCT01235416Phase 1
- IGF-1 Inhibitor Pasireotide Lar in Combination With the m-TOR Inhibitor EverolimusWithdrawnNCT01234974Phase 2
- Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With SurgeryCompletedNCT01234935Phase 2
- A Study of Ridaforolimus (MK-8669) in Combination With Dalotuzumab (MK-0646) Compared to Standard of Care Treatment in Estrogen Receptor Positive Breast Cancer Patients (MK-8669-041 AM3)CompletedNCT01234857Phase 2
- Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain MetastasesCompletedNCT01234740Phase 1
- Bosutinib In Subjects With Renal ImpairmentCompletedNCT01233882Phase 1
- MK2206 in Treating Younger Patients With Recurrent or Refractory Solid Tumors or LeukemiaCompletedNCT01231919Phase 1
- Carboplatin and Paclitaxel With or Without Cediranib Maleate in Treating Patients With Metastatic or Recurrent Cervical Cancer That Cannot Be Removed by SurgeryCompletedNCT01229930Phase 2
- Avastin and Chemotherapy Followed by a KRAS Stratified Randomization to Maintenance Treatment for First Line Treatment of Metastatic Colorectal Cancer.CompletedNCT01229813Phase 3
- Study of Crenolanib, a Selective and Potent Inhibitor of PDGFR, for the Treatment of Adult GliomasTerminatedNCT01229644Phase 2
- A Study Comparing Imatinib and Imatinib/Pegylated Interferon in Chronic Myeloid LeukemiaCompletedNCT01227356Phase 2
- Imatinib Mesylate With or Without Hydroxychloroquine in Treating Patients With Chronic Myeloid LeukemiaStatus unknownNCT01227135Phase 2
- Ursodeoxycholic Acid And Cholestasis Of PregnancyWithdrawnNCT01226823Phase 3
- A Study Of Tasocitinib In Dry Eye SubjectsWithdrawnNCT01226680Phase 2
- Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment SchedulesCompletedNCT01226316Phase 1
- Sorafenib in Combination With RAD001 in Advanced Solid Tumors Selected on Molecular TargetsSuspendedNCT01226056Phase 1/2
- Dose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS MutationsCompletedNCT01225536Phase 1
- A Study of Linifanib (ABT-869) in Combination With Carboplatin/Paclitaxel in Japanese Subjects With Non-Small Cell Lung Cancer (NSCLC)CompletedNCT01225302Phase 1
- Single and Multiple Oral Administration Study of ASP015K in Healthy Nonelderly VolunteersCompletedNCT01225224Phase 1
- Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) RepairCompletedNCT01225094Phase 2/3
- A Food Effect and QTc Study of Perifosine in Patients With Advanced MalignanciesCompletedNCT01224730Phase 1
- To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of NilotinibCompletedNCT01223898Phase 1
- Sirolimus In Autosomal Dominant Polycystic Kidney Disease And Severe Renal InsufficiencyTerminatedNCT01223755Phase 2/3
- Cisplatin, Gemcitabine Hydrochloride, and Sorafenib Tosylate in Treating Patients With Transitional Cell Cancer of the BladderStatus unknownNCT01222676Phase 2
- Study of CH5132799 Administered Orally in Patients With Advanced Solid TumorsCompletedNCT01222546Phase 1
- A Study of Fostamatinib in Subjects With Impaired Hepatic (Liver) FunctionCompletedNCT01222455Phase 1
- Safety and Efficacy Study of Nilotinib Combined With Mitoxantrone, Etoposide, and High-dose Cytarabine Induction Chemotherapy Followed by Consolidation for Patients With C-kit Positive Acute Myeloid LeukemiaTerminatedNCT01222143Phase 1/2
- Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Acute Lymphoblastic Leukemia (ALL) Philadelphia Chromosome-positive (Ph+)SuspendedNCT01222013Phase 2
- Pazopanib/DCE-MRIs in Renal Cell Carcinoma (RCC)CompletedNCT01221506Early Phase 1
- Phase II Study for Safety and Efficacy Evaluation of Imatinib Mesylate in Children With Chronic Myeloid Leukemia (CML) Philadelphia Chromosome-positive (Ph+)Status unknownNCT01221376Phase 2
- Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) GeneCompletedNCT01221077Phase 2
- Determining the Maximum Tolerated Dose of Low Dose Interferon-alpha in Conjunction With Nilotinib in Pretreated Philadelphia Chromosome Positive (Ph+) Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP)CompletedNCT01220648Phase 1