Protein Kinase Inhibitors: all 15,766 studies that test it

Page 134 of 158. Open to participants first (2,605), then studies with results posted, then the rest; newest registration first within each.

• MEK162 and RAF265 in Adult Patients With Advanced Solid Tumors Harboring RAS or BRAFV600E MutationsCompletedNCT01352273Phase 1
• Adjuvant AI Combined With ZoladexStatus unknownNCT01352091Phase 3
• Escalating Dose Study in Subjects With Relapsed or Refractory B Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, and Waldenstrom's MacroglobulinemiaCompletedNCT01351935Phase 1
• BIBF 1120 and RAD001 in Solid Tumors - Phase ICompletedNCT01349296Phase 1
• Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast CancerWithdrawnNCT01349088Phase 1/2
• Lenalidomide in Combination With a Fixed Dose of Sorafenib for the Treatment of Hepatocellular CarcinomaTerminatedNCT01348503Phase 1
• Study of RAD001 for Treatment of NF2-related Vestibular SchwannomaTerminatedNCT01345136Phase 2
• Turmeric Effect on Reduction of Serum Prolactin and Related Hormonal Change and Adenoma Size in Prolactinoma PatientsStatus unknownNCT01344291Phase 1
• Study of PI3 Kinase/mTOR Inhibitor BEZ235 Twice Daily for Advanced Solid TumorsCompletedNCT01343498Phase 1
• A Study of Complete Molecular Response for Chronic Myeloid Leukemia in Chronic Phase Patients, Treated With DasatinibCompletedNCT01342679Phase 2
• Sorafenib in Elderly Patients With Metastatic Renal Cell CarcinomaTerminatedNCT01342627Phase 2
• Safety and Tolerability Study of RAD001 and LBH589 in All Solid Tumors With Enrichment for EBV Driven TumorsStatus unknownNCT01341834Phase 1
• A Pharmacokinetics Study of the Effects of GSK2118436 on Warfarin, the Effects of Ketoconazole and Gemfibrozil on GSK2118436, and the Effects of Repeat Doses of GSK2118436 in Subjects With BRAF Mutant Solid TumorsCompletedNCT01340846Phase 1
• Determination of the Absolute Bioavailability of GSK2118436 Following a Single Oral Dose Co-Administered With an Intravenous Radiolabelled Microtracer of GSK2118436 in Subjects With BRAF Mutant Solid TumorsCompletedNCT01340833Phase 1
• Study of Pazopanib and Vorinostat in Patients With Advanced MalignanciesCompletedNCT01339871Phase 1
• BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast CancerCompletedNCT01339442Phase 1
• Open Label Regorafenib Study to Evaluate Cardiovascular Safety Parameters, Tolerability, and Anti-tumor ActivityCompletedNCT01339104Phase 1
• Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor PatientsCompletedNCT01337765Phase 1
• Pilot Study Sorafenib as Bridge to Orthotopic Liver Transplantation (OLT)TerminatedNCT01337492Early Phase 1
• Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver DiseasesStatus unknownNCT01337440Phase 4
• A Trial of Cediranib in the Treatment of Patients With Alveolar Soft Part Sarcoma (CASPS)Status unknownNCT01337401Phase 2
• GLPG0778: Multiple Ascending Oral Doses, Pharmacokinetic, Safety, and Pharmacodynamic StudyCompletedNCT01336244Phase 1
• A Study of BI 853520 in Patients With Various Types of Advanced or Metastatic CancerCompletedNCT01335269Phase 1
• Clinical Study to Evaluate Safety and Maximum Tolerated Dose of BAY1000394 Given in a 4 Week on / 2 Week Off Schedule in Subjects With Advanced MalignanciesCompletedNCT01335256Phase 1
• Temsirolimus + Sorafenib in Advanced Hepatocellular Carcinoma (HCC)WithdrawnNCT01335074Phase 1/2
• Everolimus, Rituximab, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Untreated Diffuse Large B-Cell LymphomaCompletedNCT01334502Phase 1
• Study of Axitinib in Patients With Unresectable Hepatocellular CarcinomaCompletedNCT01334112Phase 2
• Study of the Combination of Axitinib Plus Everolimus in Patients With Malignant Advanced Solid TumorsCompletedNCT01334073Phase 1
• Maximum Tolerated Dose (MTD) of Liposomal Doxorubicin in Combination With Seliciclib for Patients With Metastatic Triple Negative Breast Cancer (TNBC)WithdrawnNCT01333423Phase 1
• Everolimus, Carboplatin, and Paclitaxel in Locally Advanced Head and Neck Cancer That Cannot Be Removed by SurgeryCompletedNCT01333085Phase 1/2
• Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation TherapyWithdrawnNCT01332279Phase 1
• Aflac ST0901 CHOANOME - Sirolimus in Solid TumorsCompletedNCT01331135Phase 1
• 24-hour Efficacy of AR-12286CompletedNCT01330979Phase 2
• Curcumin PharmacokineticsCompletedNCT01330810Phase 1
• A Study to Compare Two Different Tablet Formulations of AZD8931 in Healthy Males and FemalesCompletedNCT01330758Phase 1
• Efficacy and Safety Study of GSK1120212, a MEK Inhibitor, in Subjects With Uveal MelanomaWithdrawnNCT01328106Phase 2
• Safety and Efficacy of RAD001 in Chinese Patients With Advanced Pulmonary Neuroendocrine TumorCompletedNCT01324492Phase 1
• Study of INC280 in Patients With c-MET Dependent Advanced Solid TumorsCompletedNCT01324479Phase 1
• Trial of GSK1120212 and GSK1120212 in Combination With GEM in Japanese Subjects With Solid TumorsCompletedNCT01324258Phase 1
• Transarterial Chemoembolization Using Doxorubicin Beads With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed By SurgeryStatus unknownNCT01324076Phase 3
• Efficacy of Pazopanib in Gastrointestinal Stromal Tumors (GIST)CompletedNCT01323400Phase 2
• PD0332991/Paclitaxel in Advanced Breast CancerCompletedNCT01320592Phase 1
• Experience of Erlotinib in Patients With Advanced Non-Small Cell Lung CancerSuspendedNCT01320501Phase 4
• Curcumin + Aminosalicylic Acid (5ASA) Versus 5ASA Alone in the Treatment of Mild to Moderate Ulcerative ColitisCompletedNCT01320436Phase 3
• BIBW 2992 (Afatinib) for the Treatment of Patients With HER2-positive, Hormone-refractory Prostate CancerTerminatedNCT01320280Phase 2
• Breast Cancer Study: Paclitaxel Versus Paclitaxel Plus Sorafenib in Second- or Third-line TreatmentCompletedNCT01320111Phase 2
• Effect of Ketoconazole on Regorafenib (BAY73-4506) PharmacokineticsCompletedNCT01318265Phase 1
• A Single Center, Open-label, Randomized, Two-period Crossover Food Effect Study of Single Doses of Tivozanib (AV-951) in Healthy SubjectsCompletedNCT01316848Phase 1
• A Study of ARRY-382 in Patients With Selected Advanced or Metastatic CancersCompletedNCT01316822Phase 1
• AZD8055 for Adults With Recurrent GliomasCompletedNCT01316809Phase 1
• Carboplatin, Paclitaxel, Cetuximab, and Erlotinib Hydrochloride in Treating Patients With Metastatic or Recurrent Head and Neck Squamous Cell CancerCompletedNCT01316757Phase 2
• Glivec in Prostate Cancer Patients With Rising PSA Following Radical ProstectomyCompletedNCT01316458Phase 2
• Gleevec as Maintenance Therapy After Cytogenetic Response With Nilotinib in Newly Diagnosed Chronic Myelogenous LeukemiaCompletedNCT01316250Not applicable
• Everolimus and Docetaxel in Treating Patients With Recurrent, Locally Advanced, or Metastatic Head and Neck CancerTerminatedNCT01313390Phase 1/2
• De Novo Everolimus-based Therapy for Renal Transplantation Using Rituximab InductionTerminatedNCT01312064Phase 4
• Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy SubjectsCompletedNCT01311622Phase 1
• Study of Dasatinib to Treat Philadelphia Positive Acute Lymphoblastic LeukemiaCompletedNCT01310010Phase 2
• Effects of Administration of Fostamatinib on Blood Concentrations of Pioglitazone in Healthy SubjectsCompletedNCT01309854Phase 1
• Study Evaluating Two Loading Regimens of Sunitinib or Bevacizumab Alternating With Cisplatin and Gemcitabine as Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma (NPC)CompletedNCT01309633Phase 2
• Study of Preoperative Weekly Paclitaxel and Carboplatin With Lapatinib (Tykerb®) in Patients With ErbB2-Positive Stage I-III Breast CancerStatus unknownNCT01309607Phase 2
• Study of Continuous Dosing of Sunitinib in Non GIST Sarcomas With Concomitant RadiotherapyCompletedNCT01308034Phase 1
• A Trial of Tivozanib (AV-951) in Combination With Capecitabine (Xeloda®) in Subjects With Advanced Solid TumorsCompletedNCT01306630Phase 1
• Strategies To Prevent Cardiac Allograft Vasculopathy Related Events in Heart Transplant RecipientsWithdrawnNCT01305395Not applicable
• A Study of MM-111 in Combination With Multiple Treatments in Patients With HER2 Positive CancerCompletedNCT01304784Phase 1
• A Trial of Irinotecan and BKM120 in Previously Treated Advanced Colorectal CancerCompletedNCT01304602Phase 1
• Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or MelanomaActive, not recruitingNCT01303341Phase 1
• Safety and Efficacy Study of Gemcitabine-erlotinib Versus Gemcitabine-erlotinib-capecitabine in Patients With Metastatic Pancreatic CancerCompletedNCT01303029Phase 2
• AR-12286 in Combination With LatanoprostCompletedNCT01302249Phase 2
• Study of BKM120 or BYL719 and Capecitabine in Patients With Metastatic Breast CancerCompletedNCT01300962Phase 1
• Study of PHA-848125AC in Adult Patients With Advanced/Metastatic Solid TumorsCompletedNCT01300468Phase 1
• AMG 319 Lymphoid Malignancy FIHCompletedNCT01300026Phase 1
• Tamoxifen-RAD001 Versus Tamoxifen Alone in Patients With Anti-aromatase Resistant Breast Metastatic CancerCompletedNCT01298713Phase 2
• Imatinib in KIT-negative Systemic MastocytosisCompletedNCT01297777Phase 4
• BKM120 + Carboplatin + Paclitaxel for Patients With Advanced Solid TumorsCompletedNCT01297452Phase 1
• Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Soft Tissue SarcomaWithdrawnNCT01296659Phase 1
• Safety and Tolerability of Different Dose Combinations of Ridaforolimus With MK-2206 or MK-0752 for Participants With Advanced Cancer (MK-8669-049)CompletedNCT01295632Phase 1
• A Study to Investigate the Safety and Efficacy of AT13387, Alone or in Combination With Imatinib, in Patients With GISTCompletedNCT01294202Phase 2
• Gefitinib Combined With Radiotherapy in Elderly Patients With Esophageal CancerStatus unknownNCT01291823Phase 2
• BEZ235 Trial in Patients With Advanced Endometrial CarcinomaWithdrawnNCT01290406Phase 2
• Exploratory Lapatinib (Positron Emission Tomography) PET Study in Subjects With Breast CancerCompletedNCT01290354Phase 1
• Studying the Effect of Changing Immunosuppression in Case of Polyoma BK Virus Infection of the Renal TransplantStatus unknownNCT01289301Phase 4
• BEZ235 Trial in Patients With HER2-(Human Epidermal Growth Factor Receptor 2 Negative) /HR+ (Hormonal Receptor Positive) Metastatic Breast CancerWithdrawnNCT01288092Phase 2
• Apatinib in the Treatment of Advanced Non-squamous Non-small Cell Lung CancerStatus unknownNCT01287962Phase 3
• A Study of LY2875358 in Participants With Advanced CancerCompletedNCT01287546Phase 1
• AZD6244 With Cetuximab for Solid Tumors and Colorectal CancerCompletedNCT01287130Phase 1
• A 3-Part Study to Determine the Relative Bioavailability of Capsule and Tablet Formulations of GDC-0980, the Effect of Food, and the Effect of Rabeprazole on the Pharmacokinetics of the TabletCompletedNCT01287091Phase 1
• A Pharmacokinetic Study to Access How the Body Absorbs and Removes Linifanib in Male Patients With Advanced Solid Tumors.TerminatedNCT01286974Phase 1
• Use of Individual Pharmacokinetically (PK)-Guided Sunitinib Dosing: A Feasibility Study in Patients With Advanced Solid TumorsCompletedNCT01286896Phase 1
• A Trial of Oral BEZ235 and BKM120 in Combination With Paclitaxel With or Without TrastuzumabCompletedNCT01285466Phase 1
• A Study of LY2801653 in Advanced CancerCompletedNCT01285037Phase 1
• Healthy Volunteers, Absorption, Distribution, Metabolism and Excretion (ADME) Study With Single Oral Administration of [14C] AZD8931CompletedNCT01284595Phase 1
• Study of an Investigational Drug, ASP3026, in Patients With Advanced Malignancies (Solid Tumors and B-Cell Lymphoma)CompletedNCT01284192Phase 1
• Study of Oral Lucitanib (E-3810), a Dual VEGFR-FGFR Tyrosine Kinase Inhibitor, in Patients With Solid TumorsCompletedNCT01283945Phase 1/2
• Lapatinib and RAD-001 for HER2 Positive Metastatic Breast CancerStatus unknownNCT01283789Phase 2
• A Study of BKM120 in Adult Japanese Patients With Advanced Solid TumorsCompletedNCT01283503Phase 1
• Midostaurin (PKC412) for Locally Advanced Rectal CancerCompletedNCT01282502Phase 1
• Study of Pegylated Liposomal Doxorubicin and Temsirolimus in Patients With Advanced Hepatocellular CancerWithdrawnNCT01281943Phase 2
• A Study of Carboplatin, PLD and Everolimus in Certain Gynecologic CancerCompletedNCT01281514Phase 1
• Lapatinib Ditosylate and Akt Inhibitor MK2206 in Treating Women With Metastatic Breast CancerTerminatedNCT01281163Phase 1
• Masitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-KitTerminatedNCT01280565Phase 3

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