Drug
Mitoxantrone clinical trials
Also written Novantrone, CL 232315 and Mitozantrone.
Includes 35 studies of Liposomal Mitoxantrone Hydrochloride and 3 studies of Pegylated Liposomal Mitoxantrone Hydrochloride.
- studies test it
- 172
- open now
- 22
- in phase 3
- 18
- first study started
- 1991
Keep track of what changes. Save the Mitoxantrone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Brand
Development codes
Other names
Studies by the year they started
169 studies that test it; most in 2021 (12)
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1992 | 1 |
| 1993 | 1 |
| 1994 | 3 |
| 1995 | 2 |
| 1996 | 3 |
| 1997 | 6 |
| 1998 | 3 |
| 1999 | 5 |
| 2000 | 2 |
| 2001 | 6 |
| 2002 | 4 |
| 2003 | 4 |
| 2004 | 6 |
| 2005 | 7 |
| 2006 | 7 |
| 2007 | 4 |
| 2008 | 3 |
| 2009 | 6 |
| 2010 | 6 |
| 2011 | 6 |
| 2012 | 6 |
| 2013 | 4 |
| 2014 | 3 |
| 2015 | 6 |
| 2016 | 8 |
| 2017 | 1 |
| 2018 | 5 |
| 2019 | 3 |
| 2020 | 7 |
| 2021 | 12 |
| 2022 | 7 |
| 2023 | 8 |
| 2024 | 7 |
| 2025 | 2 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 68
- Phase 2
- 100
- Phase 3
- 18
- Phase 4
- 4
- No phase
- 9
What it is tested for
Each study’s main condition, where its own words name it.
- Lymphoma
- 10
Who runs them
Industry 35 · Other 137
CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (22) · National Cancer Institute (NCI) (14) · Fred Hutchinson Cancer Center (8) · M.D. Anderson Cancer Center (6) · Institute of Hematology & Blood Diseases Hospital, China (6) · University of Washington (5) · Memorial Sloan Kettering Cancer Center (4) · St. Jude Children's Research Hospital (3)
Often tested with
Tested in the same studies.
Cytarabine (55) · Etoposide (39) · Rituximab (19) · Cyclophosphamide (18) · Prednisone (16) · Cladribine (15) · Filgrastim (12) · Fludarabine (12)
Studies
Open first, then newest update. How each study uses Mitoxantrone is read from its arms, and is right about nine times in ten.
Testing it · 172
- Rituximab, Pirtobrutinib, Lisaftoclax and Liposomal Mitoxantrone for for Richter Syndrome Transformed From CLLNot yet recruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT07831395Written as Liposomal mitoxantrone
- CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic LeukemiaRecruitingPhase 1Fred Hutchinson Cancer CenterNCT04375631Written as Mitoxantrone
- MRD-positive AML Clinical StudyRecruitingNot applicableInstitute of Hematology & Blood Diseases Hospital, ChinaNCT07131059Written as Mitoxantrone
- Multicenter, Platform-type Clinical Study of Refractory/Recurrent Acute Myeloid LeukemiaRecruitingNot applicableInstitute of Hematology & Blood Diseases Hospital, ChinaNCT06265545Written as Daunorubicin/ Idarubicin /Mitoxantrone
- Venetoclax, Azacitidine and Liposomal Mitoxantrone for Newly Diagnosed AMLRecruitingNot applicableInstitute of Hematology & Blood Diseases Hospital, ChinaNCT07490288Written as Liposomal Mitoxantrone
- TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia IIRecruitingPhase 1/2Tanja Andrea GruberNCT05848687Written as Mitoxantrone
- Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid NeoplasmsRecruitingPhase 1/2University of WashingtonNCT04797767Written as Mitoxantrone
- Modified R-MINE Regimen vs. R-GemOx Regimens on the Treatment of Late Relapsed DLBCLNot yet recruitingNot applicableThe First Affiliated Hospital with Nanjing Medical UniversityNCT07389356Written as Rituximab+Ifosfamide+Mesna+Mitoxantrone hydrochloride liposome+Etoposide
- Application of Mitoxantrone Hydrochloride Injection in Transoral Robotic Thyroid Cancer SurgeryNot yet recruitingPhase 4Daping Hospital and the Research Institute of Surgery of the Third Military Medical UniversityNCT07354698Written as mitoxantrone hydrochloride injection
- Mitoxantrone for Venetoclax Resistant Acute Myeloid LeukemiaRecruitingPhase 1University of Colorado, DenverNCT06429449Written as Mitoxantrone
- Mitoxantrone Hydrochloride Liposome and Enlonstobart Combination Treatment in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL)Not yet recruitingPhase 1/2Sun Yat-Sen University Cancer CenterNCT07288814Written as Mitoxantrone Hydrochloride Liposome & Enlonstobart
- JMT101 Combined With Mitoxantrone Liposome for Nasopharyngeal CancerNot yet recruitingPhase 2Shanghai JMT-Bio Inc.NCT06892431Written as Mitoxantrone Hydrochloride Liposome
- Chidamide in Combination With Azacitidine, Liposomal Mitoxantrone, and Prednisone (CAMP Regimen) for the Treatment of Previously Untreated Nodal TFH Cell LymphomaRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT05958719Written as liposomal mitoxantrone
- Clinical Study of Induction Therapy Options Based on Molecular Subtyping and MRD in Children and Adolescents With AMLRecruitingPhase 2Children's Hospital of Soochow UniversityNCT06221683Written as Mitoxantrone hydrochloride liposome
- Clinical Trial of VIM With VIT in Children With Relapsed and Refractory Soft Tissue Sarcoma.RecruitingPhase 2Yizhuo ZhangNCT06514313Written as Mitoxantrone Hydrochloride Liposome+Irinotecan+Vincristine
- VMAC+DLI Treatment of Patients With Relapse of AML After Allo-HSCTRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT06447090Written as Mitoxantrone hydrochloride liposome
- Efficacy and Safety of MTBF Conditioning Regimen for Salvageable Allo-HSCT in the Treatment of R/R AMLNot yet recruitingNot applicableFirst Affiliated Hospital Xi'an Jiaotong UniversityNCT06385808Written as MTBF regimen
- Mitoxantrone Hydrochloride Liposome Injection in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)RecruitingPhase 2CSPC ZhongQi Pharmaceutical Technology Co., Ltd.NCT05875428Written as Mitoxantrone Hydrochloride Liposome Injection
- The Efficacy and Safety of the RCMOP Sequential Therapy as a First-line Treatment for Patients With Intermediate-to-high Risk Diffuse Large B-cell Lymphoma Who Had Incomplete Remission.Not yet recruitingNot applicableThe First Hospital of Jilin UniversityNCT05990985Written as Mitoxantrone hydrochloride liposome injection
- Treateament of Newly Diagnosed Acute Monocytic Leukemia in ChildrenRecruitingPhase 2/3Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT05313958Written as Mitoxantrone
See all 172 studies that test Mitoxantrone →
Given in every arm · 64 — Mitoxantrone is usual care beside what is tested
- A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 MutationsRecruitingPhase 3Children's Oncology GroupNCT04293562Written as Mitoxantrone Hydrochloride
- A Study of Venetoclax in Combination With Conventional Chemotherapy in Pediatric Patients With Acute Myeloid LeukemiaRecruitingPhase 2St. Jude Children's Research HospitalNCT05955261Written as Mitoxantrone Hydrochloride
- Mitoxantrone Hydrochloride Liposome, Cytarabine, G-CSF Plus Venetoclax vs. Azacitidine Plus Venetoclax for MDS-IB2 and Secondary/Elderly AMLNot yet recruitingPhase 3Ruijin HospitalNCT07735117Written as Mitoxantrone Hydrochloride Liposome
- R-CMOP in Patients With Newly Diagnosed Diffuse Large B-cell LymphomaRecruitingPhase 1/2Institute of Hematology & Blood Diseases Hospital, ChinaNCT06594640Written as Mitoxantrone Hydrochloride Liposome
- Venetoclax, Azacitidine, and Mitoxantrone Hydrochloride Liposome Versus Idarubicin and Cytarabine in Newly Diagnosed AMLNot yet recruitingPhase 3The First Affiliated Hospital of Soochow UniversityNCT07486479Written as Mitoxantrone Hydrochloride Liposome
- Zeprumetostat, Azacitidine Combined With Lipo-MIT in R/R PTCLRecruitingPhase 2The First Affiliated Hospital of Soochow UniversityNCT07372352Written as Mitoxantrone Hydrochloride Liposome
- Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell LymphomaRecruitingPhase 1/2Sun Yat-sen UniversityNCT07093710Written as Mitoxantrone Hydrochloride Liposome
- Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II TrialRecruitingPhase 2Ming-Yuan ChenNCT07070479Written as Mitoxantrone Hydrochloride Liposome
- Mitoxantrone Hydrochloride Liposome, Standard-dose of Cytarabine and Venetoclax in the Treatment of R/R AMLRecruitingPhase 2First Affiliated Hospital of Zhejiang UniversityNCT06621212Written as mitoxantrone hydrochloride liposome
- CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML PatientsRecruitingPhase 2Princess Maxima Center for Pediatric OncologyNCT06262438Written as Mitoxantrone
- Clinical Study of Mitoxantrone Hydrochloride Liposome Combined with PD-1 Blockade in Recurrent or Metastatic NPCRecruitingPhase 2Ming-Yuan ChenNCT06472713Written as Mitoxantrone hydrochloride liposome injection
- Mitoxantrone Hydrochloride Liposome in Combination With Cytarabine and Venetoclax Regimen in Newly Diagnosed Elderly AMLRecruitingPhase 2First Affiliated Hospital of Zhejiang UniversityNCT06621199Written as Mitoxantrone hydrochloride liposome
- Linperlisib Combined With Immunochemotherapy in Relapsed/Refractory LBCLRecruitingPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT06489808Written as Mitoxantrone hydrochloride liposome
- Mitoxantrone Hydrochloride Liposome Injection, Cytarabine Combined With Venetoclax in the Treatment of R/R AMLRecruitingPhase 2First Affiliated Hospital of Zhejiang UniversityNCT06434662Written as mitoxantrone hydrochloride liposome
- Chidamide, Azacitidine Combined With GM Regimen for Relapsed and Refractory DLBCL PatientsRecruitingPhase 2The First Affiliated Hospital of Soochow UniversityNCT05823701Written as Liposomal mitoxantrone
- Clinical Study of Mitoxantrone Hydrochloride Liposome Injection Combined With Capecitabine Versus Capecitabine Monotherapy in Patients With Recurrent Metastatic Nasopharyngeal Carcinoma Who Failed Platinum-containing TreatmentNot yet recruitingPhase 3CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.NCT05717764Written as Mitoxantrone hydrochloride liposome injection
- Mitoxantrone Hydrochloride Liposome Combined With Rituximab and Lenalidomide (M+R2) in Patients With Relapsed and Refractory Diffuse Large B-Cell LymphomaNot yet recruitingPhase 2Jianfeng ZhouNCT05575973Written as Mitoxantrone Hydrochloride Liposome
- A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AMLActive, not recruitingPhase 2Novartis PharmaceuticalsNCT03591510Written as Mitoxantrone
- Safety Study of AG-120 or AG-221 in Combination With Induction and Consolidation Therapy in Participants With Newly Diagnosed Acute Myeloid Leukemia (AML) With an IDH1 and/or IDH2 MutationActive, not recruitingPhase 1Institut de Recherches Internationales ServierNCT02632708Written as mitoxantrone
- A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid LeukemiaActive, not recruitingPhase 2St. Jude Children's Research HospitalNCT03164057Written as Mitoxantrone
Showing 20 of 64.
As the comparator · 13 — what is tested is compared with Mitoxantrone
- Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic LeukemiaActive, not recruitingPhase 3National Cancer Institute (NCI)NCT02101853Written as Mitoxantrone
- A Study of ASP2215 Versus Salvage Chemotherapy In Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) With FMS-like Tyrosine Kinase 3 (FLT3) MutationCompletedPhase 3Astellas Pharma IncNCT03182244Written as Mitoxantrone
- International Randomised Phase III Clinical Trial in Children With Acute Myeloid LeukaemiaActive, not recruitingPhase 3University of BirminghamNCT02724163Written as Mitoxantrone
- Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic LeukemiaCompletedPhase 3Technische Universität DresdenNCT02688140Written as Mitoxantrone
- Trial of DFP-10917 vs Non-Intensive or Intensive Reinduction for AML Patients in 2nd/3rd/4th SalvageTerminatedPhase 3Delta-Fly Pharma, Inc.NCT03926624Written as Mitoxantrone
- A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic LeukemiaCompletedPhase 3PfizerNCT01564784Written as cytarabine and mitoxantrone
- Study of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate CancerTerminatedPhase 3ExelixisNCT01522443Written as mitoxantrone
- Study Comparing Inotuzumab Ozogamicin In Combination With Rituximab Versus Defined Investigator's Choice In Follicular Non-Hodgkin's Lymphoma (NHL)TerminatedPhase 3PfizerNCT00562965Written as mitoxantrone
- Decitabine Versus Conventional Chemotherapy for Maintenance Therapy of Acute Myeloid Leukemia With t(8;21)Status unknownPhase 4The First Hospital of Jilin UniversityNCT03026842Written as Mitoxantrone, Cytarabine
- Study of Irofulven in Patients With Hormone-refractory Prostate CancerCompletedPhase 2Eisai Inc.NCT00124566Written as Mitoxantrone
- S9916, Combination Therapy in Treating Patients With Advanced Prostate Cancer That Has Not Responded to Hormone TherapyCompletedPhase 3SWOG Cancer Research NetworkNCT00004001Written as mitoxantrone
- Taxotere Prostate Cancer New Indication Registration Trial in ChinaCompletedPhase 3SanofiNCT00436839Written as Mitoxantrone
- XRP6258 Plus Prednisone Compared to Mitoxantrone Plus Prednisone in Hormone Refractory Metastatic Prostate CancerCompletedPhase 3SanofiNCT00417079Written as mitoxantrone
Codes
What other systems call Mitoxantrone · ClinicalTrials.gg INT007848
- MeSH (NLM) D008942MitoxantroneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) BZ114NVM5PMITOXANTRONEConfirmed FDA, NLM, Wikidata
- RxNorm 7005Confirmed FDA, Wikidata
- Wikidata Q239426mitoxantroneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62050MitoxantroneOne source FDA
- DrugBank DB01204One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008942 | Mitoxantrone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | BZ114NVM5P | MITOXANTRONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 7005 | — | Confirmed FDA, Wikidata |
| Wikidata | Q239426 | mitoxantrone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62050 | Mitoxantrone | One source FDA |
| DrugBank | DB01204 | — | One source Wikidata |
Also registered as mitoxantrone hydrochloride (UNII U6USW86RD0 · RxNorm 203129).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.