Drug
Metolazone clinical trials
Also written Zaroxolyn.
- studies test it
- 19
- open now
- 6
- in phase 3
- 3
- first study started
- 2002
Keep track of what changes. Save the Metolazone studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Combined with it in one product
Studies by the year they started
19 studies that test it; most in 2024 (4)
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2003 | 1 |
| 2004 | 1 |
| 2008 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 1 |
| 2018 | 1 |
| 2019 | 2 |
| 2021 | 3 |
| 2023 | 1 |
| 2024 | 4 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 4
- Phase 3
- 3
- Phase 4
- 6
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 16
Mylan Pharmaceuticals Inc (3) · Yonsei University (2) · Unity Health Toronto (1) · Clinica Alemana de Santiago (1) · Johannes Grand (1) · Tanta University (1) · Yale University (1) · Cairo University (1)
Often tested with
Tested in the same studies.
Acetazolamide (5) · Furosemide (3) · Spironolactone (2) · Empagliflozin (1) · Ertugliflozin (1) · Chlorothiazide (1) · Dapagliflozin (1)
Studies
Open first, then newest update. How each study uses Metolazone is read from its arms, and is right about nine times in ten.
Testing it · 19
- Optimal Diuretic Therapies for Acute Heart Failure With Volume OverloadRecruitingPhase 4Johannes GrandNCT06166654Written as Metolazone 2.5 MG
- Add-on Diuretics in Acute Decompensated Heart FailureRecruitingPhase 2Tanta UniversityNCT07372040Written as metolazone
- Ertugliflozin in Chronic Heart FailureRecruitingPhase 2Yale UniversityNCT04438213Written as Metolazone
- Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume OverloadRecruitingPhase 4Cairo UniversityNCT06414759Written as Metolazone
- Role of Active Deresuscitation After Resuscitation:Not yet recruitingPhase 2Unity Health TorontoNCT06326112Written as Metolazone Tablets
- Acetazolamide or Metolazone in Acute Heart FailureNot yet recruitingNot applicableClinica Alemana de SantiagoNCT06273397Written as Metolazone 2.5 MG
- Efficacy of Diuretics in Kidney DiseaseTerminatedPhase 2Stanford UniversityNCT04542304Written as Metolazone
- Diuretic Strategies in Acute Heart Failure Patients At High Risk for Diuretic ResistanceTerminatedPhase 4Stadtspital ZürichNCT05986773Written as Metolazone
- Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649181Written as Metolazone Tablets 5 mg
- Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00650195Written as Metolazone Tablets 10 mg
- Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649051Written as Metolazone Tablets 2.5 mg
- DAPAgliflozin Versus Thiazide Diuretic in Patients With Heart Failure and Diuretic RESISTanceStatus unknownPhase 3NHS Greater Glasgow and ClydeNCT04860011Written as Metolazone Tablets
- Diuretic Effect of Metolazone Pre-dosing Versus Concurrent DosingTerminatedPhase 4University of Maryland, BaltimoreNCT03746002Written as Metolazone 60 minutes prior to furosemide
- Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic ResistanceTerminatedPhase 4University of VirginiaNCT03574857Written as Metolazone Oral Tablet
- Sequential Nephron Blockade in Acute Heart FailureStatus unknownPhase 3Policlinico Casilino ASL RMBNCT04163588Written as Metolazone
- Metolazone As Early Add On Therapy For Acute Decompensated Heart Failure (MELT-HF)--A Single Center Pilot Study.TerminatedPhase 3Aultman Health FoundationNCT02620384Written as Experimental: Metolazone
- Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart FailureTerminatedPhase 4University of North Carolina, Chapel HillNCT00904488Written as Addition of oral Metolazone
- A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)WithdrawnNot applicableYonsei UniversityNCT02047422Written as metolazone
- A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)WithdrawnNot applicableYonsei UniversityNCT01817803Written as metolazone/spironolactone
As the comparator · 3 — what is tested is compared with Metolazone
- Metolazone As Early Add On Therapy For Acute Decompensated Heart FailureWithdrawnPhase 2Scripps HealthNCT05633758Written as Metolazone
- Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart FailureCompletedPhase 4Vanderbilt UniversityNCT02606253Written as Metolazone
- AiDing Diuresis wIth Tolvaptan (ADD-IT)CompletedPhase 1Emory UniversityNCT02646540Written as Metolazone 5 mg + IV Diuretics
Codes
What other systems call Metolazone · ClinicalTrials.gg INT007826
- MeSH (NLM) D008788MetolazoneConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) TZ7V40X7VXMETOLAZONEConfirmed FDA, NLM, Wikidata
- RxNorm 6916Confirmed FDA, Wikidata
- Wikidata Q1169561metolazoneConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C650MetolazoneOne source FDA
- DrugBank DB00524One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008788 | Metolazone | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | TZ7V40X7VX | METOLAZONE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6916 | — | Confirmed FDA, Wikidata |
| Wikidata | Q1169561 | metolazone | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C650 | Metolazone | One source FDA |
| DrugBank | DB00524 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.