Ketamine: all 1,116 studies that test it

Page 3 of 12. Open to participants first (207), then studies with results posted, then the rest; newest registration first within each.

• Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early SurvivalNot yet recruitingNCT04009759Phase 1
• Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity SurgeryRecruitingNCT03756961Not applicable
• Premedication for Less Invasive Surfactant AdministrationRecruitingNCT03735563Phase 4
• Quelling of Excitotoxicity in Acute Stroke With KetamineNot yet recruitingNCT03223220Phase 2/3
• Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderRecruitingNCT03065335Phase 1
• Neurobiology of SuicideRecruitingNCT02543983Phase 2
• Ketamine Alcohol (in Treatment-Resistant Depression)RecruitingNCT02122562Phase 2
• Ketamine Administration for Postoperative Pain Management in Patients Undergoing Knee ArthroplastyCompletedNCT07059429Not applicableResults posted
• Low Dose Ketamine for Blunt Thoracic TraumaCompletedNCT06236113Phase 4Results posted
• Ketamine-assisted Therapy for Advanced GI CancerTerminatedNCT06077487Phase 4Results posted
• Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI CancersTerminatedNCT06001372Early Phase 1Results posted
• Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)CompletedNCT05907213Phase 1Results posted
• Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use DisorderCompletedNCT05796791Early Phase 1Results posted
• Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side EffectsCompletedNCT05518877Phase 4Results posted
• Anhedonia, Development, and Emotions: Phenotyping and TherapeuticsCompletedNCT05487885Phase 4Results posted
• Esketamine Induction Intubation in ICU Patients.CompletedNCT05464979Early Phase 1Results posted
• Ketamine Pilot StudyTerminatedNCT05379179Phase 4Results posted
• Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERiesCompletedNCT05279898Not applicableResults posted
• Randomized Trial of Sedative Choice for IntubationCompletedNCT05277896Phase 4Results posted
• Ketamine and Kidney Injury in Cardiac SurgeryActive, not recruitingNCT05268562Phase 4Results posted
• Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility TrialCompletedNCT05233566Phase 3Results posted
• The Using Postoperative Ketamine and Exploring the Effect on Endometriosis Pain (UPKEEEP) StudyTerminatedNCT05229653Phase 1Results posted
• Elucidating the Neurocircuitry of Irritability With High-Field Neuroimaging to Identify Novel Therapeutic TargetsCompletedNCT05046184Phase 2Results posted
• Repeated Neurocognitive Measurements in Depressed PatientsCompletedNCT04916548Phase 1/2Results posted
• Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSDCompletedNCT04889664Phase 2Results posted
• Ketamine Versus Fentanyl for Surgical AbortionsCompletedNCT04871425Phase 4Results posted
• A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal PainCompletedNCT04860804Phase 4Results posted
• An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute HeadacheCompletedNCT04860713Phase 4Results posted
• Effect of Postoperative Single Dose of Ketamine on Pain After MastectomyCompletedNCT04831736Phase 4Results posted
• A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentCompletedNCT04829318Phase 4Results posted
• The Effect of Opioid-Free Anesthesia in TMJ SurgeryCompletedNCT04724759Phase 2Results posted
• The Impact of Perioperative Ketamine Infusion on Surgical RecoveryCompletedNCT04625283Phase 4Results posted
• Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous KetamineTerminatedNCT04613453Phase 2Results posted
• A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionCompletedNCT04599855Phase 4Results posted
• Ketamine Versus Midazolam for Recurrence of Suicidality in AdolescentsCompletedNCT04592809Phase 3Results posted
• Inpatient Single Dose Interventions for Alcohol Use DisorderCompletedNCT04562779Early Phase 1Results posted
• Ketamine-enhanced Prolonged Exposure Therapy in PTSDCompletedNCT04560660Phase 2Results posted
• Ketamine for Older Adults PilotCompletedNCT04504175Phase 4Results posted
• Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric SurgeryCompletedNCT04467424Phase 2Results posted
• Low-Dose Ketamine in Children With ADNP SyndromeCompletedNCT04388774Phase 1/2Results posted
• Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19TerminatedNCT04365985Phase 2Results posted
• A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive DisorderCompletedNCT04338321Phase 3Results posted
• Initiating Ketamine in Acutely Suicidal Patients in the Emergency DepartmentTerminatedNCT04260607Phase 3Results posted
• Ketamine to Prevent PPD After CesareanCompletedNCT04227704Phase 3Results posted
• Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine SurgeryTerminatedNCT04220489Phase 2Results posted
• Ketamine for the Treatment of Opioid Use Disorder and DepressionCompletedNCT04177706Phase 2Results posted
• Effect of Ketamine on Laboratory-induced Stress in Healthy SubjectsCompletedNCT04173962Phase 2Results posted
• A Proof-of-Concept Trial on the Effect of Ketamine on FatigueCompletedNCT04141696Phase 1/2Results posted
• Ketamine Treatment Effects on Synaptic Plasticity in DepressionCompletedNCT04091971Phase 4Results posted
• Ketamine to Improve Recovery After Cesarean Delivery - Part 1CompletedNCT04037085Phase 2Results posted
• EEG Characteristics in ECTCompletedNCT04022226Early Phase 1Results posted
• Efficacy And Tolerability Of Sub-Anesthetic Ketamine In Postpartum DepressionTerminatedNCT04011592Phase 2Results posted
• Nebulized Sub-dissociative Dose Ketamine for Treating PainCompletedNCT03909607Phase 4Results posted
• Ketamine for Pain in the Emergency DepartmentTerminatedNCT03896230Phase 4Results posted
• Ketamine for Severe Adolescent Depression: Intermediate-term Safety and EfficacyTerminatedNCT03889756Phase 2/3Results posted
• Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac SurgeryCompletedNCT03861988Phase 4Results posted
• The Effects of Sedatives on Tobacco Use DisorderCompletedNCT03813121Phase 1/2Results posted
• A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric PatientsCompletedNCT03714919Phase 2Results posted
• Sub-dissociative Dose Ketamine Dosing StudyCompletedNCT03714620Phase 4Results posted
• Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF SurgeryCompletedNCT03643796Phase 4Results posted
• A Study to Evaluate Ketamine for the Treatment of Rett SyndromeCompletedNCT03633058Phase 2Results posted
• Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - KetamineCompletedNCT03621085Phase 4Results posted
• EEG Studies of Ketamine General AnesthesiaCompletedNCT03553758Phase 2/3Results posted
• Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence IntubationCompletedNCT03545503Phase 4Results posted
• IN Ketamine vs IN Midazolam and Fentanyl for Laceration RepairTerminatedNCT03528512Phase 4Results posted
• Ketamine for Treatment of MS FatigueCompletedNCT03500289Phase 1/2Results posted
• Perioperative Ketamine for Pain With Gastric BypassCompletedNCT03448068Phase 2Results posted
• A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedNCT03434041Phase 3Results posted
• Ketamine for Acute Painful Crisis in Sickle Cell Disease PatientsCompletedNCT03431285Not applicableResults posted
• Ketamine in Borderline Personality DisorderTerminatedNCT03395314Phase 2Results posted
• RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn PainTerminatedNCT03305055Phase 4Results posted
• Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive CrisisCompletedNCT03296345Phase 2Results posted
• UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness StudyCompletedNCT03284307Phase 4Results posted
• A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal FusionCompletedNCT03274453Phase 2Results posted
• Ketamine as an Adjunctive Therapy for Major DepressionCompletedNCT03256162Phase 1Results posted
• Intravenous Ketamine Plus Neurocognitive Training for DepressionCompletedNCT03237286Phase 1/2Results posted
• Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for SuicideCompletedNCT03185819Phase 2Results posted
• The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression.CompletedNCT03156504Phase 4Results posted
• ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)CompletedNCT03113968Phase 2/3Results posted
• Intraoperative Low-dose Ketamine Infusion for Patients With Obstructive Sleep ApneaTerminatedNCT03109418Phase 2/3Results posted
• 54135419SUI3002: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideCompletedNCT03097133Phase 3Results posted
• Antipruritic Effect of Topical Ketamine, Amitriptyline, and LidocaineTerminatedNCT03096444Phase 2Results posted
• Sedation Methods During Cataract SurgeryCompletedNCT03054103Phase 4Results posted
• Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) PatientsTerminatedNCT03040024Phase 4Results posted
• 54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for SuicideCompletedNCT03039192Phase 3Results posted
• Ketamine vs HydromorphoneCompletedNCT03001843Phase 4Results posted
• The Effect of Ketamine on the Length of Hospital Stay of Patients Hospitalized With Suicidal Ideation.TerminatedNCT02997722Phase 4Results posted
• Low Dose Intravenous Ketamine in Treatment Resistant Depression PatientsCompletedNCT02935595Phase 2Results posted
• Effect of Ketamine on Analgesia Post-Cardiac SurgeryCompletedNCT02925858Phase 4Results posted
• Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic PainCompletedNCT02920528Phase 3Results posted
• A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant DepressionCompletedNCT02918318Phase 2Results posted
• Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency DepartmentCompletedNCT02916927Phase 4Results posted
• The UTHealth Ketamine ProjectTerminatedNCT02882711Phase 2Results posted
• A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionCompletedNCT02782104Phase 3Results posted
• Pain Reduction With Intranasal Medications for Extremity InjuriesCompletedNCT02778880Phase 3Results posted
• Cognitive Recovery After Electroconvulsive Therapy and General AnesthesiaCompletedNCT02761330Not applicableResults posted
• The CHECK Trial: A Comparison of Headache Treatment in the Emergency Department: Compazine Versus KetamineTerminatedNCT02735343Phase 3Results posted
• Multimodal Analgesia in Cardiac Surgery (Pilot Study)TerminatedNCT02734940Phase 4Results posted
• Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure TherapyTerminatedNCT02727998Phase 2Results posted
• Ketamine for Acute Migraine in the Emergency DepartmentCompletedNCT02697071Not applicableResults posted

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