Irinotecan: all 829 studies that test it

Page 3 of 9. Open to participants first (121), then studies with results posted, then the rest; newest registration first within each.

• Bevacizumab Plus Irinotecan Plus Carboplatin for Recurrent Malignant Glioma (MG)CompletedNCT00953121Phase 2Results posted
• Study of Gemcitabine, Irinotecan and Panitumumab in Patients With Advanced and Metastatic Biliary Tract AdenocarcinomaCompletedNCT00948935Phase 2Results posted
• Study to Evaluate Mechanisms of Acquired Resistance to PanitumumabCompletedNCT00891930Phase 2Results posted
• Study of Irinotecan and Bevacizumab With Temozolomide in Refractory/Relapsed Central Nervous System (CNS) TumorsCompletedNCT00876993Phase 1Results posted
• Pre-operation Chemo and Antibody Therapy Followed by Surgical Resection and Adjuvant Chemoradiation for Gastric CancerCompletedNCT00857246Phase 2Results posted
• Bendamustine With Irinotecan Followed by Etoposide/Carboplatin for Patients With Extensive Stage Small Cell Lung CancerCompletedNCT00856830Phase 1/2Results posted
• Irinotecan/Cisplatin, Potentially Curative Surgery With or Without Floxuridine, Followed by Capecitabine for Stomach and Gastro-esophageal Junction (GEJ) CancersTerminatedNCT00848783Phase 2Results posted
• Phase II Study of Irinotecan and PanitumumabCompletedNCT00836277Phase 2Results posted
• Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk NeuroblastomaTerminatedNCT00808899Phase 2Results posted
• Pre-operative Chemotherapy Plus Bevacizumab With Early Salvage Therapy Based on PET Assessment of Response in Patients With Locally Advanced But Resectable Gastric and GEJ AdenocarcinomaCompletedNCT00737438Phase 2Results posted
• A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM)TerminatedNCT00735436Phase 2Results posted
• Irinotecan, Carboplatin, and Sunitinib in First Line Extensive-Stage Small Cell Lung CancerCompletedNCT00695292Phase 2Results posted
• Irinotecan and Etoposide in Treating Patients With Recurrent, Locally Advanced, or Metastatic Breast CancerCompletedNCT00693719Phase 2Results posted
• Genotype-directed Neoadjuvant Chemoradiation for Rectal CarcinomaCompletedNCT00682786Phase 2Results posted
• Panitumumab and Irinotecan as Third-Line Therapy in Treating Patients With Metastatic Colorectal CancerCompletedNCT00655499Phase 2Results posted
• A Study of Xeloda (Capecitabine) in Combination With Avastin + Short Course Chemotherapy in Patients With Metastatic Colorectal CancerTerminatedNCT00642603Phase 2Results posted
• Irinotecan and Cisplatin in Treating Patients With Recurrent or Metastatic Head and Neck CancerCompletedNCT00639769Phase 2Results posted
• Irinotecan and Temozolomide in Treating Patients With Breast Cancer Who Have Received Previous Treatment for Brain MetastasesCompletedNCT00617539Phase 2Results posted
• Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and GliosarcomasCompletedNCT00597402Phase 2Results posted
• Phase II Trial of Preoperative Combined Modality Therapy for Esophageal Carcinoma: Cisplatin-Irinotecan Followed by Radiation Therapy With Concurrent Cisplatin and Irinotecan.CompletedNCT00590031Phase 2Results posted
• Irinotecan and Cediranib in Treating Patients With Metastatic Colorectal Cancer That Did Not Respond to Previous Oxaliplatin, Fluoropyrimidine, and BevacizumabTerminatedNCT00588900Phase 2Results posted
• Effect of Panitumumab on the Pharmacokinetics of IrinotecanCompletedNCT00563316Phase 1Results posted
• Pertuzumab and Cetuximab in Treating Patients With Previously Treated Locally Advanced or Metastatic Colorectal CancerCompletedNCT00551421Phase 1/2Results posted
• Safety/Efficacy Study of Imprime PGG With Cetuximab in Patients With Recurrent/Progressive Colorectal CarcinomaCompletedNCT00545545Phase 1/2Results posted
• Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone SarcomaTerminatedNCT00544778Phase 2Results posted
• Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line TherapyTerminatedNCT00499369Phase 3Results posted
• A Phase II Safety and Tolerability Study of Bevacizumab When Added to Single-agent Chemotherapy to Treat Patient With Breast Cancer Metastatic to BrainTerminatedNCT00476827Phase 2Results posted
• Irinotecan and Carboplatin as First-Line Therapy in Treating Patients With Extensive-Stage Small Cell Lung CancerCompletedNCT00469898Phase 2Results posted
• Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by SurgeryCompletedNCT00467142Phase 2Results posted
• Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colorectal CancerTerminatedNCT00449163Phase 2Results posted
• Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy in Treating Patients With Metastatic or Unresectable Locally Advanced Small Bowel CancerCompletedNCT00433550Phase 2Results posted
• Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or GliosarcomaCompletedNCT00433381Phase 2Results posted
• Thalidomide and Temozolomide or Camptothecin-11 (CPT-11) in Patients With GliomasCompletedNCT00412542Phase 2Results posted
• Combination of Irinotecan and Temozolomide in Children With Brain Tumors.CompletedNCT00404495Phase 2Results posted
• Cetuximab, Cisplatin, and Irinotecan in Treating Patients With Metastatic Esophageal Cancer, Gastroesophageal Junction Cancer, or Gastric Cancer That Did Not Respond to Previous Irinotecan and CisplatinCompletedNCT00397904Phase 2Results posted
• Docetaxel, Cisplatin, Irinotecan and Bevacizumab (TPCA) in Metastatic Esophageal and Gastric CancerCompletedNCT00394433Phase 2Results posted
• Bevacizumab and Irinotecan to Treat Brain TumorsTerminatedNCT00393094Phase 2Results posted
• Irinotecan and Carboplatin in Treating Patients With Metastatic or Recurrent Small Cell Lung CancerCompletedNCT00387660Phase 2Results posted
• Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade GliomaCompletedNCT00381797Phase 2Results posted
• Phase II Study of Irinotecan HCI for Recurrent Anaplastic Astrocytomas, Mixed Malignant Gliomas, and OligodendrogliomasTerminatedNCT00360828Phase 2Results posted
• Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer PatientsCompletedNCT00354978Phase 2Results posted
• Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed RhabdomyosarcomaCompletedNCT00354835Phase 3Results posted
• Irinotecan, Cisplatin, Bevacizumab, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Esophageal CancerCompletedNCT00354679Phase 2Results posted
• Irinotecan and Cetuximab for Colorectal Cancer as Second Line TherapyCompletedNCT00336856Phase 2Results posted
• Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney TumorsCompletedNCT00335556Phase 2Results posted
• Cisplatin, Irinotecan, and Radiation Therapy in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By SurgeryCompletedNCT00316862Phase 2Results posted
• Study of Bevacizumab Combined With Capecitabine and Either Oxaliplatin or Irinotecan as First Course of Treatment for Patients With Colorectal Cancer That Has Spread Beyond the ColonTerminatedNCT00314353Phase 2Results posted
• Irinotecan and Temozolomide in Treating Young Patients With Recurrent NeuroblastomaCompletedNCT00311584Phase 2Results posted
• Individualized Drug Treatment for Treating Patients With Pancreatic CancerTerminatedNCT00276744Phase 2Results posted
• PhII ICb With/Without Erbitux in MBC PtsActive, not recruitingNCT00248287Phase 2Results posted
• Study of Sequential Topoisomerase, Irinotecan/Oxaliplatin - Etoposide /Carboplatin in Extensive Small Cell Lung Cancer (SCLC)CompletedNCT00240097Phase 2Results posted
• Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in Locally Advanced Rectal CancerTerminatedNCT00216086Phase 2Results posted
• Gemcitabine/Irinotecan/ZD1839 vs Paclitaxel/Carboplatin/Etoposide/ZD1839 in Carcinoma of Unknown Primary SiteCompletedNCT00193596Phase 3Results posted
• Irinotecan, Carboplatin and Radiation Therapy Followed by Bevacizumab in Limited Stage Small Cell Lung CancerCompletedNCT00193375Phase 2Results posted
• A Study of the Combination of Pemetrexed and Irinotecan Every Two Weeks in Metastatic Colorectal CancerCompletedNCT00191984Phase 2Results posted
• Study of Irinotecan and Docetaxel in Patients With Metastatic or Unresectable Gastric or Gastroesophageal Junction AdenocarcinomaCompletedNCT00183872Phase 2Results posted
• Study Of Irinotecan Hydrochloride (Campto(R)) And Cisplatin Versus Etoposide And Cisplatin In Small Cell Lung CancerCompletedNCT00143455Phase 3Results posted
• Comparing Irinotecan and 5 FU/FA To 5-FU/FA After Resection Of Liver Metastases For Colorectal CancerCompletedNCT00143403Phase 3Results posted
• Irinotecan Study For Cervical CancerCompletedNCT00136955Phase 2Results posted
• Evaluating Panitumumab (ABX-EGF) in Patients With Metastatic Colorectal CancerCompletedNCT00111761Phase 2Results posted
• Study of Erbitux™ (Cetuximab) in Pediatric Patients With Refractory Solid TumorsCompletedNCT00110357Phase 1Results posted
• S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal CancerTerminatedNCT00109850Phase 2Results posted
• Irinotecan in Treating Patients With Metastatic or Inoperable Thyroid CancerTerminatedNCT00100828Phase 2Results posted
• Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal CancerCompletedNCT00098787Phase 2Results posted
• Gemcitabine and Irinotecan in Treating Patients With Locally Advanced or Metastatic Bladder CancerTerminatedNCT00089128Phase 2Results posted
• Gemcitabine and Irinotecan in Treating Patients With Locally Advanced Unresectable or Metastatic Kidney CancerTerminatedNCT00089102Phase 2Results posted
• Phase II Study of Oxaliplatin, Irinotecan, and Capecitabine in Advanced Gastric/Gastroesophageal Junction CarcinomaCompletedNCT00084617Phase 2Results posted
• Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal CancerCompletedNCT00081289Phase 2Results posted
• Gemcitabine and Irinotecan in Treating Patients With Cancer of Unknown PrimaryCompletedNCT00066781Phase 2Results posted
• Irinotecan and Cisplatin in Treating Patients Who Are Undergoing Surgery For Locally Advanced Cancer of the Stomach or Gastroesophageal JunctionCompletedNCT00062374Phase 2Results posted
• Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Extensive-Stage Small Cell Lung CancerCompletedNCT00057837Phase 2Results posted
• S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung CancerCompletedNCT00045162Phase 3Results posted
• Radiation Therapy and Chemotherapy Before and After Surgery in Treating Patients With Esophageal CancerCompletedNCT00033657Phase 2Results posted
• Capecitabine and Irinotecan in Treating Patients With Locally Advanced, Recurrent, or Metastatic Colorectal CancerCompletedNCT00022698Phase 2Results posted
• Gemcitabine and Albumin-Bound Paclitaxel Combined With Liposomal Irenotecan (II) With or Without SHR-1701 as Neoadjuvant Therapy for Resectable or Borderline Resectable Pancreatic CancerActive, not recruitingNCT07806110Phase 2
• Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the BodyTerminatedNCT06820957Phase 2/3
• Bemarituzumab in FGFR2b+ Patients With Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction, Who Failed at Least One Prior Line of Palliative ChemotherapyActive, not recruitingNCT06680622Phase 2
• Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar CarcinomaSuspendedNCT06620302Phase 1/2
• A Study to Investigate the Efficacy and Safety of Ivonescimab Combined With Irinotecan Liposome as Second-line Regimen for SCLCCompletedNCT06478043Phase 2
• A Study Comparing BL-B01D1 With Chemotherapy of Physician's Choice in Patients With Recurrent or Metastatic Esophageal Squamous Cell Carcinoma(PANKU-Esophagus01)Active, not recruitingNCT06304974Phase 3
• Phase 2 Study of Irinotecan Liposome Injection, Oxaliplatin, 5-fluorouracil/Levoleucovorin in Japanese Participants Not Previously Treated for Metastatic Adenocarcinoma of the PancreasCompletedNCT06225999Phase 2
• Neoadjuvant Chemoradiation With Nal-IRI and Capecitabine Guided by UGT1A1 Status in Patients With Rectal CancerActive, not recruitingNCT06210971Phase 2
• NEO-adjuvant Chemo-immunotherapy in Pancreatic CancerActive, not recruitingNCT06094140Phase 2
• Efficacy and Safety of SBRT Followed by Tislelizumab Plus Cetuximab and Irinotecan in Patients With Previously Treated RAS Wild-type Advanced Refractory Colorectal CancerStatus unknownNCT05799443Phase 2
• The Efficacy and Safety of Fluzoparib Plus Irinotecan as Second-line Treatment in Patients With Homologous Recombination Deficiency (HRD) Metastatic Colorectal Cancer.Status unknownNCT05732129Phase 2
• Phase I Dose Escalation and Pharmacokinetics Clinical Trial of Mitoxantrone Hydrochloride Liposome in Children With Relapsed and Refractory Lymphoma and Solid TumorsActive, not recruitingNCT05620862Phase 1
• Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation and Continuing ResponseActive, not recruitingNCT05610163Phase 2/3
• A Study of Navicixizumab Monotherapy or in Combination in Patients With Select Advanced Solid TumorsStatus unknownNCT05453825Phase 2
• A Study to Compare Onivyde Manufactured at Two Different Production Sites in Adult Participants With Advanced Cancer in the PancreasCompletedNCT05383352Phase 1
• Concomitant Intraperitoneal and Systemic Chemotherapy in Patients With Extensive Peritoneal Carcinomatosis of Gastric OriginCompletedNCT05379790Phase 1
• A Study of Combination Therapies With or Without Pembrolizumab (MK-3475) and/or Chemotherapy in Participants With Advanced Esophageal Cancer (MK-3475-06A)CompletedNCT05342636Phase 1/2
• Phase IIa Study of Nimotuzumab to Treat Colorectal CancerCompletedNCT05278728Phase 1/2
• Intraperitoneal Aerosolized Nanoliposomal Irinotecan (Nal-IRI) in Peritoneal Carcinomatosis From Gastrointestinal CancerActive, not recruitingNCT05277766Phase 1
• Combination Liposomal Irinotecan and Pembrolizumab For Triple-Negative Breast Cancer (TNBC) With Brain Metastases (BM)WithdrawnNCT05255666Phase 2
• Short-course Radiotherapy Followed by Consolidation Chemotherapy. 2021-001206-29Active, not recruitingNCT05253846Phase 2
• SMMART Adaptive Clinical Treatment (ACT) TrialWithdrawnNCT05238831Early Phase 1
• Selinexor Combination Ph 1 StudyWithdrawnNCT05177276Phase 1/2
• Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal CancerStatus unknownNCT05160727Phase 2
• Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON)CompletedNCT05153239Phase 3
• A Study of Irinotecan Hydrochloride Liposome in Advanced Solid TumorsCompletedNCT05086822Phase 1

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