Irinotecan: all 829 studies that test it

Page 2 of 9. Open to participants first (121), then studies with results posted, then the rest; newest registration first within each.

• 5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.RecruitingNCT04689347Phase 1/2
• PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration SamplesRecruitingNCT04683315Phase 2
• Folfox+Irinotecan+Chemort In Esophageal CancerRecruitingNCT04656041Phase 2
• FaR-RMS: An Overarching Study for Children and Adults With Frontline and Relapsed RhabdoMyoSarcomaRecruitingNCT04625907Phase 1/2
• Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the PancreasRecruitingNCT04617457Phase 2
• FOLFIRINOX vs FLOT Chemotherapy for Resectable Gastric or Esophagogastric Junction AdenocarcinomaRecruitingNCT04393584Phase 2/3
• Safety of Combining Irinotecan With 5-FU, Leucovorin/Folinic Acid, Oxaliplatin, and Docetaxel ChemotherapiesRecruitingNCT04361708Phase 1
• PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric CancerRecruitingNCT04329494Phase 1
• A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWTRecruitingNCT04322318Phase 2
• Study of Recombinant Human Endostatin Combined with Temozolomide and Irinotecan in Recurrent GliomasRecruitingNCT04267978Phase 2
• High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)RecruitingNCT04221035Phase 3
• Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel CancersRecruitingNCT04205968Phase 2
• Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent SarcomaRecruitingNCT04199026Not applicable
• Oxaliplatin and Liposomal Irinotecan (Plus Trastuzumab for HER2-positive Disease) in Advanced Esophageal and Gastric AdenocarcinomaRecruitingNCT04150640Phase 2
• Tumor Subtypes in Subjects on FOLFIRINOX With Non-Metastatic Pancreatic CancerRecruitingNCT03977233Phase 2
• A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRCRecruitingNCT03303495Phase 3
• Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the LiverRecruitingNCT02885753Phase 3
• European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory TumorsRecruitingNCT02813135Phase 1/2
• Phase 1 Dose-escalating Study of MM-398 (Irinotecan Sucrosofate Liposome Injection) Plus Intravenous Cyclophosphamide in Recurrent or Refractory Pediatric Solid TumorsRecruitingNCT02013336Phase 1
• Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS TumorsRecruitingNCT01356290Phase 2
• I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast CancerRecruitingNCT01042379Phase 2
• Study To Investigate the Efficacy and Safety of Sitravatinib in Combination With Tislelizumab in Participants With Esophageal Squamous Cell CarcinomaTerminatedNCT05461794Phase 2Results posted
• CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's SarcomaActive, not recruitingNCT05440786Phase 2Results posted
• Irinotecan Liposome and Bevacizumab for the Treatment of Platinum Resistant, Recurrent, or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal CancerCompletedNCT04753216Phase 2Results posted
• A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal CancerActive, not recruitingNCT04607421Phase 3Results posted
• Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)Active, not recruitingNCT04385277Phase 2Results posted
• FOLFIRINOX With Digoxin in Patients With Resectable Pancreatic CancerTerminatedNCT04141995Phase 2Results posted
• Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal CancerActive, not recruitingNCT04117945Phase 2Results posted
• TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO StudyCompletedNCT04109924Phase 2Results posted
• Trifluridine/Tipiracil and Irinotecan for the Treatment of Advanced Refractory Biliary Tract CancerCompletedNCT04072445Phase 2Results posted
• NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary CancerActive, not recruitingNCT04005339Phase 2Results posted
• Liposomal Irinotecan in Combination With Oxaliplatin, Leucovorin, and 5-fluorouracil for Patients With Locally Advanced Pancreatic Carcinoma:CompletedNCT03861702Phase 2Results posted
• Assessing a Regorafenib-irinotecan Combination Versus Regorafenib Alone in Metastatic Colorectal Cancer PatientsActive, not recruitingNCT03829462Phase 3Results posted
• Phase Ib/II Trial of Nal-Irinotecan and Nivolumab as Second-Line Treatment in Patients With Advanced Biliary Tract CancerCompletedNCT03785873Phase 1/2Results posted
• Liposomal Irinotecan, Fluorouracil and Leucovorin in Treating Patients With Refractory Advanced High Grade Neuroendocrine Cancer of Gastrointestinal, Unknown, or Pancreatic OriginTerminatedNCT03736720Phase 2Results posted
• Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid TumorsCompletedNCT03709680Phase 2Results posted
• A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or CholangiocarcinomaCompletedNCT03693807Phase 2Results posted
• Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction CancerCompletedNCT03641313Phase 2Results posted
• A Study of Gemcitabine, Nab-paclitaxel, Capecitabine, Cisplatin, and Irinotecan in Metastatic Pancreatic CancerCompletedNCT03535727Phase 1/2Results posted
• A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With Irinotecan and TemozolomideTerminatedNCT03495921Phase 3Results posted
• A Study of the Safety and Activity of Liposomal Irinotecan in Combination With the 5-FU and Oxaliplatin in the Preoperative Treatment of Pancreatic AdenocarcinomaActive, not recruitingNCT03483038Phase 2Results posted
• A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer TreatmentCompletedNCT03428958Phase 1/2Results posted
• S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients With Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by SurgeryCompletedNCT03365882Phase 2Results posted
• Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary CancerActive, not recruitingNCT03337087Phase 1/2Results posted
• Pevonedistat, Irinotecan, and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or LymphomaCompletedNCT03323034Phase 1Results posted
• A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction CancersCompletedNCT03279237Phase 1Results posted
• Novel PET/CT Imaging Biomarkers of CB-839 in Combination With Panitumumab and Irinotecan in Patients With Metastatic and Refractory RAS Wildtype Colorectal CancerCompletedNCT03263429Phase 1/2Results posted
• Study Evaluating the Safety and Efficacy of Eribulin Mesilate in Combination With Irinotecan Hydrochloride in Children With Refractory or Recurrent Solid TumorsCompletedNCT03245450Phase 1/2Results posted
• A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Participants With Advanced Solid TumorsCompletedNCT03184870Phase 1/2Results posted
• Ramucirumab Plus Irinotecan for Previously Treated Advanced Gastric or Gastro-esophageal Junction AdenocarcinomaCompletedNCT03141034Phase 2Results posted
• BrUOG 329 Onivyde & Metronomic Temozolomide in Recurrent GlioblastomaTerminatedNCT03119064Phase 1/2Results posted
• Dinutuximab and Irinotecan Versus Irinotecan to Treat Subjects With Relapsed or Refractory Small Cell Lung CancerCompletedNCT03098030Phase 2/3Results posted
• Study of Irinotecan Liposome Injection (ONIVYDE®) in Patients With Small Cell Lung CancerCompletedNCT03088813Phase 3Results posted
• Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid TumorsCompletedNCT02975882Phase 1Results posted
• A Study of Olaratumab Alone and in Combination With Standard Chemotherapies in Children With CancerCompletedNCT02677116Phase 1Results posted
• Phase 2 Evaluation of Multi-modality Algorithm for Non-metastatic Adenocarcinoma of Pancreas or AmpullaTerminatedNCT02626520Phase 2Results posted
• Avelumab in Third-Line Gastric Cancer (JAVELIN Gastric 300)CompletedNCT02625623Phase 3Results posted
• S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by SurgeryCompletedNCT02562716Phase 2Results posted
• Study of Nanoliposomal Irinotecan (Nal-IRI)-Containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic AdenocarcinomaCompletedNCT02551991Phase 2Results posted
• A Two-part Phase IIb Trial of Vigil (Bi-shRNAfurin and GMCSF Augmented Autologous Tumor Cell Immunotherapy) in Ewing's SarcomaCompletedNCT02511132Phase 2Results posted
• FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic Colorectal CancerTerminatedNCT02508077Phase 2Results posted
• FDG-PET Directed Treatment in Improving Response in Patients With Locally Advanced Stomach or Gastroesophageal Junction CancerTerminatedNCT02485834Phase 2Results posted
• Molecularly Tailored Therapy for Patients With Metastatic Cancer of the Esophagus and StomachTerminatedNCT02358863Not applicableResults posted
• Preoperative Folfirinox for Resectable Pancreatic Adenocarcinoma - A Phase II StudyTerminatedNCT02345460Phase 2Results posted
• Study of Gemcitabine/Taxotere/Xeloda (GTX) in Combination With Cisplatin and Irinotecan in Subjects With Metastatic Pancreatic CancerCompletedNCT02324543Phase 1/2Results posted
• Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast CancerCompletedNCT02312622Phase 2Results posted
• Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade GliomasActive, not recruitingNCT02192359Phase 1Results posted
• Efficacy and Tolerance Evaluation in FOLFIRINOX Dose Adjusted in Elderly Patients With a Metastatic Pancreatic CancerCompletedNCT02143219Phase 2Results posted
• Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal CancerCompletedNCT02138617Phase 2Results posted
• Efficacy And Safety Of Xeliri + Avastin Followed By Xelox + Avastin Or Reverse Sequence In Metastatic Colorectal CancerCompletedNCT02119026Phase 2Results posted
• Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid TumorsCompletedNCT02095132Phase 1/2Results posted
• Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic CancerCompletedNCT02047474Phase 2Results posted
• 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With VorinostatCompletedNCT02035137Phase 2Results posted
• Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer PatientsCompletedNCT01941316Phase 1/2Results posted
• A Study Of PF-05212384 Plus Irinotecan Vs Cetuximab Plus Irinotecan In Patients With KRAS And NRAS Wild Type Metastatic Colorectal CancerTerminatedNCT01925274Phase 2Results posted
• Pegylated Irinotecan NKTR 102 in Treating Patients With Relapsed Small Cell Lung CancerCompletedNCT01876446Phase 2Results posted
• MM-398 (Nanoliposomal Irinotecan, Nal-IRI) to Determine Tumor Drug Levels and to Evaluate the Feasibility of Ferumoxytol Magnetic Resonance Imaging to Measure Tumor Associated Macrophages and to Predict Patient Response to TreatmentCompletedNCT01770353Phase 1Results posted
• Colorectal Cancer MetastaticCompletedNCT01670721Phase 3Results posted
• A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic AdenocarcinomaCompletedNCT01660711Phase 2Results posted
• A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRICompletedNCT01634555Phase 2Results posted
• Irinotecan for Previously Treated, Advanced, Non-Small Cell Lung CancerTerminatedNCT01607554Phase 1/2Results posted
• Preoperative Folfirinox, Radiation Therapy for Resectable Adenocarcinoma of the PancreasCompletedNCT01560949Phase 2Results posted
• S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction CancerCompletedNCT01498289Phase 2Results posted
• Study of MM-398 With or Without 5-FU/LV, Versus 5-FU/LV in Patients With Metastatic Pancreatic CancerCompletedNCT01494506Phase 3Results posted
• Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGFTerminatedNCT01367275Phase 2Results posted
• FOLFIRINOX in Patients With Inoperable Pancreatic CancerTerminatedNCT01359007Phase 2Results posted
• Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings SarcomaTerminatedNCT01313884Phase 2Results posted
• Trial of ICM With or Without AZD2281 (Olaparib) in Patients With Advanced Pancreatic CancerCompletedNCT01296763Phase 1Results posted
• A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B)CompletedNCT01286818Phase 1Results posted
• Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal CancerTerminatedNCT01280643Not applicableResults posted
• Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal TumorsCompletedNCT01217437Phase 2Results posted
• Bevacizumab, Irinotecan and Temozolomide for Relapsed or Refractory NeuroblastomaCompletedNCT01114555Phase 2Results posted
• Irinotecan and Bevacizumab for Recurrent Ovarian CancerCompletedNCT01091259Phase 2Results posted
• Panitumumab and Irinotecan for Malignant GliomasTerminatedNCT01017653Phase 2Results posted
• Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus TumorsTerminatedNCT01014767Phase 3Results posted
• Cetuximab Plus Irinotecan in Colorectal Cancer Patients Who Progressed After Failure With Cetuximab Plus IrinotecanTerminatedNCT01004159Phase 2Results posted
• A Study of Vincristine, Escalating Doses of Irinotecan, Temozolomide and Bevacizumab (Vit-b) in Pediatric and Adolescent Patients With Recurrent or Refractory Solid Tumors of Non-hematopoietic OriginCompletedNCT00993044Phase 1Results posted
• Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver CancerCompletedNCT00980460Phase 3Results posted
• Avastin/Temozolomide/Irinotecan for Unresectable/Multifocal Glioblastoma MultiformeCompletedNCT00979017Phase 2Results posted
• A Study of Avastin (Bevacizumab) and Irinotecan Versus Temozolomide Radiochemistry in Patients With GlioblastomaCompletedNCT00967330Phase 2Results posted

← Irinotecan overview