Drug
Epacadostat clinical trials
Also written INCB024360.
- studies test it
- 50
- open now
- 1
- in phase 3
- 7
- first study started
- 2010
Keep track of what changes. Save the epacadostat studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Development codes
Combined with it in one product
Studies by the year they started
50 studies that test it; most in 2018 (17)
| Year | Studies |
|---|---|
| 2010 | 1 |
| 2012 | 2 |
| 2013 | 3 |
| 2014 | 4 |
| 2015 | 3 |
| 2016 | 4 |
| 2017 | 8 |
| 2018 | 17 |
| 2019 | 4 |
| 2020 | 3 |
| 2022 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 20
- Phase 2
- 33
- Phase 3
- 7
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 20 · Other 30
Incyte Corporation (17) · National Cancer Institute (NCI) (3) · University of Chicago (3) · Washington University School of Medicine (2) · Roswell Park Cancer Institute (2) · City of Hope Medical Center (2) · Insel Gruppe AG, University Hospital Bern (2) · Memorial Sloan Kettering Cancer Center (1)
Often tested with
Tested in the same studies.
Pembrolizumab (17) · Durvalumab (2) · Nivolumab (2) · Cytarabine (2) · Sirolimus (1) · Nogapendekin alfa inbakicept (1) · Parsaclisib (1) · Nelitolimod (1)
Studies
Open first, then newest update. How each study uses epacadostat is read from its arms, and is right about nine times in ten.
Testing it · 50
- Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal CancerRecruitingPhase 1/2Washington University School of MedicineNCT03516708Written as Epacadostat
- Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304)CompletedPhase 3Incyte CorporationNCT03358472Written as Epacadostat
- ALCMI-005: Pembrolizumab and Epacadostat in Treating Patients With Extensive Stage Small Cell Lung CancerWithdrawnPhase 2City of Hope Medical CenterNCT03402880Written as Epacadostat
- Pembrolizumab (MK-3475) Plus Epacadostat vs Standard of Care in mRCC (KEYNOTE-679/ECHO-302)CompletedPhase 3Incyte CorporationNCT03260894Written as Epacadostat
- A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced SarcomaActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT03414229Written as Epacadostat
- A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic MelanomaTerminatedPhase 1/2Incyte CorporationNCT01604889Written as Epacadostat
- A Study of Atezolizumab in Combination With Epacadostat in Subjects With Previously Treated Stage IIIB or Stage IV Non-Small Cell Lung Cancer and Previously Treated Stage IV Urothelial CarcinomaTerminatedPhase 1Incyte CorporationNCT02298153Written as Epacadostat
- Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent GliomasCompletedPhase 2Washington University School of MedicineNCT03532295Written as Epacadostat
- An Umbrella Study to Determine the Safety and Efficacy of Various Monotherapy or Combination Therapies in Neoadjuvant Urothelial CarcinomaTerminatedPhase 2Incyte CorporationNCT04586244Written as epacadostat
- Phase I/II Study of Immunotherapy Combination BN-Brachyury Vaccine, M7824, N-803 and Epacadostat (QuEST1)CompletedPhase 1/2National Cancer Institute (NCI)NCT03493945Written as Epacadostat
- A Phase 3 Study of Pembrolizumab + Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma (Keynote-252 / ECHO-301)CompletedPhase 3Incyte CorporationNCT02752074Written as pembrolizumab + epacadostat
- Pembrolizumab in Combination With Epacadostat or Placebo in Cisplatin-ineligible Urothelial Carcinoma (KEYNOTE-672/ECHO-307)CompletedPhase 3Incyte CorporationNCT03361865Written as Epacadostat
- Pembrolizumab Plus Epacadostat vs Pembrolizumab Plus Placebo in Metastatic Non-Small Cell Lung Cancer (KEYNOTE-654-05/ECHO-305-05)CompletedPhase 2Incyte CorporationNCT03322540Written as Epacadostat
- Pembrolizumab + Epacadostat vs Pembrolizumab + Placebo in Recurrent or Progressive Metastatic Urothelial CarcinomaCompletedPhase 3Incyte CorporationNCT03374488Written as Epacadostat
- Epacadostat Before Surgery in Treating Patients With Newly Diagnosed Stage III-IV Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal CancerCompletedEarly Phase 1National Cancer Institute (NCI)NCT02042430Written as Epacadostat
- Testing Whether the Combination of Two Immunotherapy Drugs Have Activity in Recurrent or Persistent Clear Cell Ovarian CancerCompletedPhase 2National Cancer Institute (NCI)NCT03602586Written as Epacadostat
- Epacadostat and Pembrolizumab in Patients With GISTTerminatedPhase 2Columbia UniversityNCT03291054Written as Epacadostat
- Epacadostat and Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Junction or Gastric CancerCompletedPhase 2George Albert FisherNCT03196232Written as Epacadostat
- Optimizing Antitumor Immunity Using Plasmid Electroporation, Pembrolizumab, and EpacadostatTerminatedPhase 2Chase Heaton, MDNCT03823131Written as Epacadostat
- Epacadostat (INCB24360) in Combination With Sirolimus in Advanced MalignancyActive, not recruitingPhase 1Chao HuangNCT03217669Written as Epacadostat
See all 50 studies that test epacadostat →
Given in every arm · 9 — epacadostat is usual care beside what is tested
- Safety and Efficacy of Retifanlimab (INCMGA00012) Alone or in Combination With Other Therapies in Participants With Advanced or Metastatic Endometrial Cancer Who Have Progressed on or After Platinum-based Chemotherapy.CompletedPhase 2Incyte CorporationNCT04463771Written as epacadostat
- Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)TerminatedPhase 1/2Incyte CorporationNCT02959437Written as Epacadostat
- A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)CompletedPhase 1/2Incyte CorporationNCT02327078Written as Epacadostat
- Epacadostat, Pembrolizumab, and CRS-207, With or Without CY/GVAX Pancreas in Patients With Metastatic Pancreas CancerCompletedPhase 2Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT03006302Written as Epacadostat
- A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723)CompletedPhase 1/2Incyte CorporationNCT03085914Written as Epacadostat
- A Study of Epacadostat and Nivolumab in Combination With Immune Therapies in Participants With Advanced or Metastatic Malignancies (ECHO-208)TerminatedPhase 1/2Incyte CorporationNCT03347123Written as Epacadostat
- INCAGN01876 in Combination With Immune Therapies in Subjects With Advanced or Metastatic MalignanciesTerminatedPhase 1/2Incyte Biosciences International SàrlNCT03277352Written as Epacadostat
- A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of INCB001158 Plus Epacadostat, With or Without Pembrolizumab, in Advanced Solid TumorsTerminatedPhase 1/2Incyte CorporationNCT03361228Written as Epacadostat
- Itacitinib Combined With INCB024360 and/or Itacitinib Combined With INCB050465 in Advanced Solid TumorsTerminatedPhase 1Incyte CorporationNCT02559492Written as Epacadostat
Codes
What other systems call epacadostat · ClinicalTrials.gg INT000589
- MeSH (NLM) C000613752epacadostatOne source NLM
- UNII (FDA) 71596A9R13EPACADOSTATConfirmed FDA, NLM, Wikidata
- Wikidata Q126607104EpacadostatConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C92582EpacadostatOne source FDA
- DrugBank DB11717One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000613752 | epacadostat | One source NLM |
| UNII (FDA) | 71596A9R13 | EPACADOSTAT | Confirmed FDA, NLM, Wikidata |
| Wikidata | Q126607104 | Epacadostat | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C92582 | Epacadostat | One source FDA |
| DrugBank | DB11717 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.