Drug
Dornase alfa clinical trials
Also written Pulmozyme.
- studies test it
- 32
- open now
- 4
- in phase 3
- 5
- first study started
- 2003
Keep track of what changes. Save the dornase alfa studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Other names
Combined with it in one product
Studies by the year they started
32 studies that test it; most in 2020 (6)
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2004 | 1 |
| 2005 | 3 |
| 2006 | 2 |
| 2007 | 4 |
| 2008 | 3 |
| 2009 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2013 | 1 |
| 2016 | 2 |
| 2019 | 1 |
| 2020 | 6 |
| 2021 | 1 |
| 2022 | 1 |
| 2025 | 1 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 3
- Phase 2
- 14
- Phase 3
- 5
- Phase 4
- 9
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 29
Genentech, Inc. (3) · University of Jena (2) · QuantumLeap Healthcare Collaborative (1) · University of Colorado, Denver (1) · University of Melbourne (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · University Hospital, Tours (1) · The Alfred (1)
Often tested with
Tested in the same studies.
Deoxyribonuclease I (2) · Remdesivir (1) · Imatinib (1) · Dexamethasone (1) · Cenicriviroc (1) · Icatibant (1) · Apremilast (1) · Celecoxib (1)
Studies
Open first, then newest update. How each study uses dornase alfa is read from its arms, and is right about nine times in ten.
Testing it · 32
- Dornase Alfa and Cisplatin in Refractory Germ Cell Cancer.RecruitingPhase 2National Cancer Institute, SlovakiaNCT07121322Written as dornase alfa i.v. and cisplatin
- Reduction of SystemiC Inflammation After Ischemic Stroke by Intravenous DNase Administration (ReSCInD)RecruitingPhase 2Ludwig-Maximilians - University of MunichNCT05880524Written as Dornase Alfa
- Inhaled Dornase Alpha to Reduce Respiratory Failure After Severe TraumaRecruitingPhase 3University Hospital, Strasbourg, FranceNCT03368092Written as Dornase Alfa Inhalant Solution [Pulmozyme]
- Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory FailureRecruitingPhase 2Jon SimmonsNCT04445285Written as Pulmozyme/ Recombinant human deoxyribonuclease (rh-DNase)
- Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)CompletedPhase 4University of Colorado, DenverNCT00419380Written as dornase alfa (Pulmozyme®)
- Improving Early Reperfusion With Adjuvant Dornase Alfa in Large Vessel Ischemic Stroke (EXTEND-IA DNase)CompletedPhase 2University of MelbourneNCT05203224Written as Dornase Alfa
- I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill PatientsActive, not recruitingPhase 2QuantumLeap Healthcare CollaborativeNCT04488081Written as dornase alfa
- DISmantling COvid iNduced Neutrophil ExtraCellular Traps (DISCONNECT-1)CompletedPhase 1McGill University Health Centre/Research Institute of the McGill University Health CentreNCT04409925Written as rhDNase I
- Usefulness of DORNASE in COVID-19 on HFNOTerminatedPhase 4University Medical Centre LjubljanaNCT05139901Written as Dornase Alfa
- The Safety and Tolerability of Intra-abdominal t-PA and DNase on Peritonitis in Peritoneal Dialysis PatientsTerminatedPhase 1Sir Charles Gairdner HospitalNCT01478698Written as recombinant deoxyribonuclease (DNase)
- RhDNase and Biodistribution of PMN Serine Proteases in Cystic Fibrosis SputumCompletedPhase 4University Hospital, ToursNCT00843817Written as Pulmozyme
- Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19Status unknownNot applicableDemocritus University of ThraceNCT05279391Written as Dornase Alfa Inhalant Product
- Pulmozyme to Improve COVID-19 ARDS OutcomesStatus unknownPhase 2Boston Children's HospitalNCT04402944Written as Pulmozyme
- rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host DiseaseTerminatedPhase 1/2University of Illinois at ChicagoNCT02702518Written as rhDNase I
- Dornase Alpha for the Treatment of COVID-19Status unknownPhase 2Acibadem UniversityNCT04432987Written as Pulmozyme
- Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.CompletedPhase 2The AlfredNCT01952470Written as Dornase Alfa
- Effectiveness of Pulmozyme in Infants With Cystic FibrosisCompletedPhase 2Nationwide Children's HospitalNCT00179998Written as Recombinant Human DNase (Pulmozyme)
- Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)CompletedPhase 4Georgetown UniversityNCT01356147Written as Dornase alfa
- Dornase Alpha Versus Hypertonic Saline for Lung Atelectasis in Non-Cystic Fibrosis PatientsCompletedNot applicableUniversity of OklahomaNCT00671723Written as Dornase alpha
- A Trial of Pulmozyme Withdrawal on Exercise Tolerance in Cystic Fibrosis Subjects With Severe Lung Disease (TOPIC)TerminatedPhase 4Genentech, Inc.NCT00434278Written as Dornase alfa
See all 32 studies that test dornase alfa →
As the comparator · 3 — what is tested is compared with dornase alfa
- Efficacy and Safety of Tigerase® vs. Pulmozyme® in Patients With Cystic FibrosisCompletedPhase 3AO GENERIUMNCT04468100Written as Pulmozyme®
- A Comparative Safety and Pharmacokinetic Study of JHL1922 and Pulmozyme® in Healthy SubjectsCompletedPhase 1JHL Biotech, Inc.NCT03586076Written as dornase alfa
- Comparison of Inhaled Mannitol and rhDNase in Children With Cystic FibrosisCompletedPhase 2SyntaraNCT00117208Written as mannitol + pulmozyme
Codes
What other systems call dornase alfa · ClinicalTrials.gg INT005947
- UNII (FDA) 953A26OA1YDORNASE ALFAConfirmed FDA, Wikidata
- RxNorm 337623Confirmed FDA, Wikidata
- Wikidata Q2067922dornase alfaConfirmed FDA, Wikidata
- NCI Thesaurus C81664Dornase AlfaOne source FDA
- DrugBank DB00003One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | 953A26OA1Y | DORNASE ALFA | Confirmed FDA, Wikidata |
| RxNorm | 337623 | — | Confirmed FDA, Wikidata |
| Wikidata | Q2067922 | dornase alfa | Confirmed FDA, Wikidata |
| NCI Thesaurus | C81664 | Dornase Alfa | One source FDA |
| DrugBank | DB00003 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.